A heart failure study by NEOMED scientists in collaboration with Temple University researchers was recently highlighted in the Journal of Cardiac Failure. Takhar Kasumov, Ph.D., an associate professor of pharmaceutical sciences, is one of the senior authors of “Proteome Dynamics and Bioinformatics Reveal Major Alterations in the Turnover Rate of Functionally Related Cardiac and Plasma Proteins in a Dog Model of Congestive Heart Failure,” published in the Journal (2021, Nov. 14).
In this paper, the authors applied a proteome dynamics method developed by Dr. Kasumov’s group to study the turnover rates (synthesis and degradation) of cardiac and plasma proteins in a dog model of congestive heart failure.
The study, for the first time in a large mammal, demonstrated multiple heart failure-related alterations in functionally related proteins. This study may facilitate discovery of new molecular markers of heart failure and alleviate medical and financial burdens in disease therapy.
Proteomics in Heart Failure
Investigators from Stanford University and the University of Michigan also wrote an editorial titled “Proteomics in Heart Failure: From Benchtop to Bedside” that highlighted findings of the paper by Dr. Kasumov and his colleagues.
Within the Diabetes, Obesity and Metabolism research focus area at NEOMED, Dr. Kasumov’s laboratory studies the pathogenesis of obesity-associated metabolic diseases – including nonalcoholic fatty liver disease (NAFLD) and diabetes – and their cardiovascular complications.