Bio

Before joining NEOMED, I held the position of assistant professor at the Cleveland Clinic Lerner College of Medicine and was a staff member (equivalent to a hospital setting professor) within the Department of Hepatology at Cleveland Clinic in Cleveland, Ohio. In 2015, I became an assistant professor in the Department of Pharmaceutical Sciences within the College of Pharmacy and a founding director of the Mass Spectrometry Core at NEOMED.

I have actively engaged in service at local, national and international levels. Funding for my research has been provided by the NIH, AHA, ADA and industrial grants. The findings of our research have been published in such journals as the Journals of Molecular Cellular Proteomics, Proteomics Research and Clinical Endocrinology and Metabolism.

Area of Expertise/Research Interests

Our group applies high-throughput unbiased metabolomics and proteomics approaches to understand the pathogenesis of obesity-associated metabolic diseases, including nonalcoholic fatty liver disease (NAFLD) and diabetes, and their cardiovascular complications. We helped to develop the heavy water-based metabolic labeling approach for global proteome dynamics studies, which are currently extensively used by multiple research labs around the world.

Educational Background

Dr. Kasumov is a faculty member at NEOMED, College of Pharmacy, Department of Pharmaceutical Sciences.

Dr. Kasumov earned his Ph.D. in Organic Chemistry from Moscow State University in Russia. He was trained in intermediary metabolism and stable isotope-based metabolomics and proteomics studies at Case Western Reserve University.

Courses

• Principles of Drug-Body-Interaction (PDBI)
• Prologue Dissecting a Scientific Article (DSA)
• System Biology: Omics technologies (SBOT)
• Human Anatomy, Physiology and Pathophysiology (HAPP)

Academic & Professional Activities

• American Diabetes Association
• American Heart Association
• American Society of Mass Spectrometry

Awards

• American Heart Association Grant-in-Aid Award
• American Diabetes Association Innovation Award
• Mikati Foundation for Liver Disease Research Award

Distinctions

• Editorial Board Member, Journal of Chromatography & Separation Techniques, 2013
• Editorial Board Member, Journal of Discoveries, 2015
• Standing Member, Innovative Basic Science (IBS) Review Committee at ADA, 2015
• Standing Member, Institutional Research Advancement Award (AIREA) Review Committee at AHA, 2017
• Ad Hoc Reviewer, Scientific and Technological Israel-Italy Collaboration Grant Review Committee, 2017

Presentations

• American Diabetes Association 2018 Meeting: Lipids and Lipoproteins Session, Orlando, FL.
• American Heart Association: ATVB 2018 meeting, Kinetics Methods and Modeling session, San Francisco, CA.
• American Heart Association: ATVB 2017 meeting, High Density Lipoprotein Session, Minneapolis, MN.
• Department of Chemistry, University of South Florida, Tampa, FL (2015).
• Metabolomics Symposium on Obesity, Diabetes and Cardiovascular Disease at Harvard Medical School, Boston, MA (2013).

Publications

• Kashyap S., Ösme A., Golizeh M., Lee K., Ilchenko S., Bena J., Kasumov T. Increased Glycation Reduces the Stability of ApoAI and Increases HDL Dysfunction in Diet-controlled Type 2 Diabetes. Endocrin. and Clin Metabolism, 2018, 103(2):388-396.
• Golizeh M., Lee K., Ilchenko S., Ösme A., Bena J., Sadygov R., Kashyap S., Kasumov T. Increased Serotransferrin and Ceruloplasmin Turnover in Diet-Controlled Patients with Type 2 Diabetes, Free Radic Biol Med., 2017, 113, 461-469.
• Li L, Bebek G, Previs S, Smith JD, Sadygov RG, McCullough AJ, Willard B, Kasumov T. Proteome Dynamics Reveals Pro-Inflammatory Remodeling of Plasma Proteome in a Mouse Model of NAFLD. J Proteome Res. 2016; 15(9):3388-404.
• Kasumov T, Li L, Li M, Gulshan K, Kirwan J, Liu X, Previs S, Willard B, Smith J, McCullough A, Ceramide as a Mediator of Non-alcoholic Fatty Liver Disease Associated Atherosclerosis. PLOSE ONE, 2015, 10(5):e0126910. doi: 10.1371/journal.pone.0126910. eCollection 2015.
• Le L, Willard B, Sadygov R, Kirwan J, Stanley WC, McCullough AJ, Previs S, *Kasumov T, Plasma Proteome Dynamics: Analysis of Lipoproteins and Acute Phase Response Proteins with 2H2O-metabolic labeling. Mol Cell Proteomics, 2012; 11 (7):1-16. PMCID: PMC3394944.