In this lecture, Dr. Dugan explains how the MAO inhibitors work and the mechanisms behind the potential risks. She also discusses the therapeutic benefits of these medications and how to use them safely. By the end of this lecture, you will be able to: 1) describe the mechanism of action of the monoamine oxidase inhibitors (MAOIs), 2) identify relevant interactions of MAOIs with medications and foods, and 3) evaluate efficacy data of MAOIs in treatment of depression.