Academic Title(s)

• Professor of Anatomy and Neurobiology

Bio

I obtained my Ph.D. degree from Aligarh Muslim University, India.

As a postdoctoral fellow at the Centre du Immunologie du Marseille-Luminy, France, I carried out research on the cloning of cytotoxic T cell-specific gene transcripts. As a postdoctoral fellow and then Research Associate at Mayo Clinic, I carried out research on the characterization and immunogenetics of collagen-induced arthritis in mice model of RA. I then moved to the Division of Rheumatology, Case Western Reserve University, where I expanded my research to include studies on the cartilage homeostasis in health and disease with particular emphasis on OA.

I have also trained several post-doctoral fellows during my tenure at the Case Western Reserve University in Cleveland, and at the University of South Carolina in Columbia, S.C.

At NEOMED, I am supervising a graduate student and training 3 Post-Doctoral Fellows to become independent investigators.

Area of Expertise/Research Interests

My research at NEOMED, funded by NIH, focuses on the role of small non-coding RNAs and novel genes in the pathogenesis of osteoarthritis. I examine the mechanisms that regulate anabolic genes and are disturbed or disrupted in osteoarthritis (OA) using both in vitro and in vivo approaches.

Educational Background

• B. Sc.(Hons) Aligarh Muslim University, Aligarh, India. 1972
• M. Sc. (Zoology) Aligarh Muslim University, Aligarh, India. 1974
• M. Phil. Aligarh Muslim University, Aligarh, India. 1975
• Ph.D. Aligarh Muslim University, Aligarh, India. 1979

Publications

Ansari, M.Y., Novak K., and Haqqi T.M. (2022) “ERK1/2-Mediated Activation of DRP1 Regulates Mitochondrial Dynamics and Apoptosis in Chondrocytes” Osteoarthritis Cartilage, 30, 315-328 PMID: 34767958

Ansari MY, Ball HC, Wase SJ, Novak K, Haqqi TM. (2021) “Lysosomal dysfunction in osteoarthritis and aged cartilage triggers apoptosis in chondrocytes through Bax mediated release of Cytochrome c”. Osteoarthritis Cartilage, 29, 100-112, PMID:33161099.

Ansari MY, Ahmad N, Voleti S, Wase SJ, Novak K, Haqqi TM. (2020) Mitochondrial dysfunction triggers catabolic response in chondrocytes via ROS mediated activation of JNK/AP1 pathway. J Cell Sci, 30, 133(22), PMID:33097606

Ansari MY, Khan NM, Ahmad N, Green J, Novak K, Haqqi TM. Genetic inactivation of ZCCHC6 suppresses IL-6 expression and reduces the severity of experimental osteoarthritis in mice. Arthritis Rheumatol. 2019. 71(4):583-593. PMID: 30302948

Green JA, Ansari MY, Ball HC, Haqqi TM. tRNA-derived fragments (tRFs) regulate post-transcriptional gene expression via AGO-dependent mechanism in IL-1β stimulated chondrocytes. Osteoarthritis Cartilage. 2020, 28(8):1102-1110. PMID: 32407895

View more publications on the NIH site.