Appointment

• Professor, Department of Integrative Medical Sciences

BioGRAPHY

Dr. William Chilian earned a B.A. degree from St. Olaf College, a M.S. from Texas Tech University, and a Ph.D. from the University of Missouri.

Dr. Chilian has held faculty positions at the University of Iowa, Texas A&M University, Medical College of Wisconsin, and Louisiana State University Health Science Center.

Dr. Chilian has received numerous awards including:

• Research Career Development Award, NIH;
• Distinguished Teaching Award, Texas A&M University;
• Kenneth A. Ardoin/Pfizer Superchair of Basic Cardiovascular Research, Louisiana State University;
• Outstanding Faculty Research Award and the Liebelt Award for Faculty Excellence, NEOMED;
• Distinguished Service Award, American Heart Association; and
• the Patriots Award, Department of Defense.

Dr. Chilian has 160 peer reviewed publications and editorials, and an h-index of 63 placing his contributions as unique.

Area of Expertise/Research Interests

Dr. Chilian’s work focuses on adaptations of the coronary circulation to physiological and pathophysiological stresses. One area concentrates on mechanisms of regulation of blood flow to the heart, emphasizing the consequences of abnormal regulation occurring in heart failure. A second area focuses on stimulating growth of collateral arteries in the heart. Collateral vessels have the potential to develop into bypasses that re-route flow around blockages in coronary arteries.

Educational Background

• Ph.D., Physiology, University of Missouri, 1980
• M.S., Zoology, Texas Tech University, 1976
• B.A., St. Olaf College, 1974

Courses

• Physiological Basis of Medicine
• Principles of Medical Science

Academic & Professional Activities

• Microcirculatory Society: Member of Council, Past-President
• American Heart Association: Executive Committee, Council on Arteriosclerosis and Vascular Biology; Member, Portage/Summit County Board of Directors
• Editorial Boards: Basic Research in Cardiology; Arteriosclerosis, Thrombosis and Vascular Biology; American Journal of Physiology: Heart and Circulatory Physiology
• Grant Funding: National Institutes of Health, What Mechanisms Underlie Coronary Collateral Growth? December 1, 2016 -November 30, 2021
• Grant Funding: National Institutes of Health, The Critical Role of the Coronary Microcirculation in Heart Failure. June 1, 2017-May 31, 2021

Awards

• Robert M. Berne Distinguished Lecturer, American Physiological Society
• Eugene M. Landis Award, Microcirculatory Society
• Carl J. Wiggers Award, American Physiological Society
• Spinoza Award, University of Amsterdam
• Konrad Witzig Award, Cardiac Dynamics Society

Distinctions

• Associate Editor, Circulation Research, 2008 to present
• Associate Editor, International Journal of Cardiology, 2016 to present
• Associate Editor, American Journal of Physiology: Heart and Circulatory Physiology, 1992-2012
• President, Microcirculatory Society, 2016-2017
• Chair, Cardiovascular Section, American Physiological Society, 2004-2006

Featured Publications

• Yin L, Ohanyan V, Pung YF, Delucia A, Bailey E, Enrick M, Stevanov K, Kolz CL, Guarini G, Chilian WM. Induction of vascular progenitor cells from endothelial cells stimulates coronary collateral growth. Circ Res. 2012;110:241-252
• Pung YF, Sam WJ, Stevanov K, Enrick M, Chen CL, Kolz C, Thakker P, Hardwick JP, Chen YR, Dyck JR, Yin L, Chilian WM. Mitochondrial oxidative stress corrupts coronary collateral growth by activating adenosine monophosphate activated kinase-alpha signaling. Arterioscler Thromb Vasc Biol. 2013;33:1911-1919
• Ohanyan V, Yin L, Bardakjian R, Kolz C, Enrick M, Hakobyan T, Kmetz JG, Bratz I, Luli J, Nagane M, Khan N, Hou H, Kuppusamy P, Graham J, Fu FS, Janota D, Oyewumi MO, Logan SJ, Lindner JR and Chilian WM. Requisite Role of Kv1.5 Channels in Coronary Metabolic Dilation. Circ Res. 2015;117:612-21
• Guarini G, Kiyooka T, Ohanyan V, Pung YF, Marzilli M, Chen YR, Chen CL, Kang PT, Hardwick JP, Kolz CL, Yin L, Wilson GL, Shokolenko I, Dobson JG, Jr., Fenton R and Chilian WM. Impaired coronary metabolic dilation in the metabolic syndrome is linked to mitochondrial dysfunction and mitochondrial DNA damage. Basic Res Cardiol. 2016;111:29.
• Ohanyan V, Yin L, Bardakjian R, Kolz C, Enrick M, Hakobyan T, Luli J, Graham K, Khayata M, Logan S Kmetz J, and Chilian WM. Kv1.3 Channels Facilitate the Connection Between Metabolism and Blood Flow in the Heart. Microcirculation. 2016; doi:10.111/micc.12334.

Presentations

• The Causes and Consequences of Coronary Microvascular Disease. University of Pisa; Pisa, Italy; June 2016
• The Importance of the Coronary Microcirculation in Heart Failure. University of Rome LaSapienza; Rome, Italy, June 2016
• Is it time to think Big About Small Vessels in the Heart? International Vascular Biology Organization; Boston, Massachusetts; October 2016.
• Critical Role of Mitochondria in Endothelial Function. American Physiological Society, Summer Conference on the Science of Aging; Denver, Colorado, August 2017
• Is Heart Failure a Vascular Disease? Great Wall International Conference on Cardiology; Beijing, China; October 2017