In this lecture, Dr. Dugan discusses the impact of nicotine on schizophrenia. By the end of this lecture, you will be able to: 1) describe the actions of nicotine on neurotransmitters, 2) list potential reasons for high use of nicotine products, specifically cigarettes in patients with schizophrenia, and 3) identify evidence of nicotine’s actions in patients with schizophrenia.