Academic Titles(s)

• Graduate Faculty Advsg Status College of Graduate Studies
• Associate Professor of Molecular Virology and Cancer Biology

Bio

My research studies are concerned with the understanding of how certain human papillomaviruses (HPVs) induce uterine cervical cancer, a major cause of women mortality worldwide. There are now known to be a number of other cancers associated with these viruses, such as head and neck tumors and various skin cancers.

Area of Expertise/Research Interests

• Human papillomaviruses and cervical cancer.
• Activation of p53 therapeutic pathways within pre-cancerous and cancer cells.
• Adenoviruses as gene expression vectors
• iPS stem cells and organ regeneration
• Latent adenoviruses and human papillomaviruses in tonsil tissue
• Human papillomavirus oncogene effects on cervical cancer cell metabolism
• Flaxseed lignans development as natural product intervention and chemoprotection against uterine cervical and head and neck cancers caused by human papilloma

Educational Background

• Post-doctoral Research Associate, Molecular Virology, State University of New York, 1981-1986
• Ph.D., Biochemistry, Purdue University, 1981
• B.S., Chemistry, John Carroll University, 1975

Courses

• Infectious Diseases Senior Elective 2009
• Research Ethics (invited lecturer) “Scientific Misconduct and Professionalism” Graduate School 2008
• Cancer Biology course Kent State Univ invited lecturer 2009-
• Cell Signaling Kent State Univ invited lecturer 2009-
• Recombinant DNA, Kent State Univ. invited lecturer 2009-
• Infection and Immunity (Medical School) lectures and laboratory assignments: Course Director as of 2015
• Molecules to Cells (Medical School) Co-course director 2009-2015
• Human values in medicine reflections 2012-2013
• Principles of Medical Science invited lecture on the Microbiome

Academic & Professional Activities

• International Society for Stem Cell Research
• Cleveland Virology Group
• American Society for Virology
• American Society for Biochemistry and Molecular Biology
• American Society for Microbiology

Awards

• Graduated Magna cum laude
• David Ross Fellow
• National Research Service Award

Distinctions

• Integrative Medical Sciences Tenure Track Faculty Search Committee Chair
• Integrative Medical Sciences Faculty Search Committee
• Faculty Workload Policy Committee
• Northeast Ohio Medical University College of Medicine Chair of the Faculty Forum Meeting
• Northeast Ohio Medical University College of Medicine M1/M2 Curriculum Committee

Presentations

• Northeast Ohio Medical University October 14, 2015. “Influenza” as part of the Mini-medical School
• Youngstown State University May 3, 2013. Biogenetics and Modern Medicine
• University of Akron, Biology Department, November 10, 2011. Reactivation of the p53 tumor suppressor protein by natural plant products within human papillomavirus induced cancers
• Kent State University, Chemistry Department, November 4, 2009. Reactivation of the tumor suppressor p53 by plant lignans within cervical cancer cells
• Cleveland Virology Group & Case Western Reserve University March 1, 2006. A Plant lignans and metabolic derivatives that reactivate p53: their potential use as anti viral and anti tumor therapeutic agents.

Publications

• Angiotensin type I receptor blockade in conjunction with enhanced Akt activation restores coronary collateral growth in the metabolic syndrome. Jadhav R, Dodd T, Smith E, Bailey E, Delucia AL, Russell JC, Madison R, Potter B, Walsh K, Jo H, Rocic P. Am J Physiol Heart Circ Physiol. 2011 May;300(5):H1938-49. doi: 10.1152/ajpheart.00282.2010. Epub 2011 Feb 18. PMID: 21335466.
• A plant lignan, 3′-O-methyl-nordihydroguaiaretic acid, suppresses papillomavirus E6 protein function, stabilizes p53 protein, and induces apoptosis in cervical tumor cells. Allen KL, Tschantz DR, Awad KS, Lynch WP, DeLucia AL. Mol Carcinog. 2007 Jul;46(7):564-75. PMID: 17393435.
• Gene expression profiling of microglia infected by a highly neurovirulent murine leukemia virus: implications for neuropathogenesis. Dimcheff DE, Volkert LG, Li Y, DeLucia AL, Lynch WP. Retrovirology. 2006 May 12;3:26. PMID: 16696860.