APPOINTMENTS

• Professor Emeritus of Molecular Virology and Neuroscience
• Graduate Faculty III College of Graduate Studies

Bio

My laboratory is interested in understanding how viral and abnormal host proteins induce progressive non-inflammatory neurodegenerative diseases, particularly those characterized by motor neuron degeneration and spongiosis.

Educational Background

• Chemical Engineering, University of Akron, 1976
• B.S., Physical Sciences and Biological Sciences (double major), Colorado State University, 1982
• Ph.D., Biochemistry, Molecular and Cell Biology (Neurobiology-Minor), Cornell University, 1988
• Postdoctoral Training, Rocky Mountain Laboratories, NIAID, NIH, 1988-94

Courses

• Graduate Cellular and Molecular Neurosciences
• Infection and Immunity-1
• Cellular Signaling: Immune system signaling
• Molecules to Cells
• Graduate Systems Neuroscience

Academic & Professional Activities

• United States Army Medical Research and Materiel Command Grant Review Committees.
• ZRG1 F01 (20) Brain Disorders and Clinical Neuorsciences Fellowship Study Section.
• Co-Chair, ZRG1 F01 (20) Brain Disorders and Related Neurosciences Fellowship Study Section.
• Chair, ZRG1 F01-F (20) L, Brain Disorders, Language, Communication and Related Neurosciences and Fellowship Study Section.
• Neuroscience and Ophthalmic Imaging Technologies Study Section (NOIT).

Awards

• National Research Service Award
• Cornell University Graduate Training Fellowship Awards
• Intramural Research Training Award
• Amyotrophic Lateral Sclerosis Assocation Young Investigator Award
• Outstanding Faculty Research Award

Distinctions

• American Society for Microbiology
• International Society for NeuroVirology
• American Society of Virology
• American Association for the Advancement of Science

Presentations

• Heal Ohio 2009 Conference on Wound Healing. Rootstown, Ohio. October 21, 2009. “Neurogenesis in CNS Injury”.
• Northeastern Ohio Universities Colleges of Medicine and Pharmacy. Department of Anatomy and Neurobiology. October 29, 2009. “Listening for holes in the brain: neurophysiological correlates of retrovirus-induced spongiform neurodegeneration.”
• Cleveland Clinic- Lerner Research Institute.  Department of Neuroscience.  Cleveland, OH.  January 20, 2010.  Retrovirus-induced neurodegeneration: listening for holes in the brain.
• Cleveland Neurodegenerative Disease Group “Data on the Table”. Cleveland, OH.  May 8, 2011.  “Is oligodendroglial death in retrovirus-induced spongiform neurodegeneration murder or simply collateral damage?”
• Degenerative Disease Program Seminar Series. Sanford-Burnham Medical Research Institute.  La Jolla, CA. February 2014. Cellular mechanisms of neurodegeneration in retrovirus-induced motor neuron disease.

Publications

• Sivaramakrishnan, S. and W. P. Lynch. 2017. Rebound from Inhibition: Self-Correction against Neurodegeneration? J Clin Cell Immunol. doi:10.4172/2155-9899.1000492 PMID: 28775912.
• Li Y., Dunphy, J.M., Pedraza, C.E., Lynch, C.R., Cardona, S.M., Macklin, W.B., and W.P. Lynch. 2016. Ecotropic Murine Leukemia Virus Infection of Glial Progenitors Interferes with Oligodendrocyte Differentiation: Implications for Neurovirulence. J Virol. 90:3385-99. doi: 10.1128/JVI.03156-15. PMID: 26764005.
•  Li, Y., Davey, R. A., Sivaramakrishnan, S., and W.P. Lynch. 2014. Post-inhibitory rebound neurons and networks are disrupted in retrovirus-induced spongiform neurodegeneration. J.Neurphysiol. 112(3):683-704. PMID: 25252336. PMCID: PMC4122699.
• Renszel, K.M., Traister, R.S., Li, Y. and W.P. Lynch. 2013. Unique N-Linked Glycosylation of CasBrE Env Influences Its Stability, Processing and Viral Infectivity but Not Its Neurotoxicity. J.Virol. 87(15):8372-87. PMID: 23698308.
• Li, Y., Cardona, S. M., Traister, R. S. and W. P. Lynch. 2011. Retrovirus-induced spongiform neurodegeneration is mediated by unique central nervous system viral targeting and expression of env alone. J. Virol. 85(5):2060-78.  PMID: 21191010. PMCID: PMC3067788.