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William Lynch Ph.D.

Associate Professor of Molecular Virology and Neuroscience

Integrative Medical Sciences

 

Phone: (330)325-6137

Location: F-345

 


William P. Lynch, Ph.D.

Associate Professor of Molecular Virology and Neuroscience
Department of Integrative Medical Sciences
College of Medicine
wonk@neomed.edu

Education

Ph.D., Cornell University, Ithaca, N.Y. - 1988

B.S., Colorado State University, Fort Collins, Colo. - 1982

Chemical Engineering, University of Akron, Akron, Ohio - 1974-1976

Professional Experience

Associate Professor, Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, Ohio - 2003-Present

Faculty, Graduate Program in Neuroscience, and Cellular & Molecular Biology, School of Biomedical Sciences, Kent State University, Kent, Ohio - 1997-Present

Assistant Professor, Department of Microbiology/Immunology, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio - 1997-2003

Instructor, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School - 1996-1997

Recent Publications

Dr. Lynch's publications listed in PubMed

Li Y, Cardona SM, Traister RS, Lynch WPRetrovirus-induced spongiform neurodegeneration is mediated by unique central nervous system viral targeting and expression of env alone. J Virol. 2011 Mar;85(5):2060-78. Epub 2010 Dec 29. PMID: 21191010

Li Y, Lynch WPMisfolding of CasBrE SU is reversed by interactions with 4070A Env: implications for gammaretroviral neuropathogenesis. Retrovirology. 2010 Nov 5;7:93. PMID: 21054857

Ourednik V, Ourednik J, Xu Y, Zhang Y, Lynch WP, Snyder EY, Schachner M. Cross-talk between stem cells and the dysfunctional brain is facilitated by manipulating the niche: evidence from an adhesion molecule. Stem Cells. 2009 Nov;27(11):2846-56. PMID: 19785036

Allen, K.A., Tschantz, D., Awad,K., Lynch, W., DeLucia, A. 2007. A plant lignan, 3’-O-methyl nordihydroguaiaretic acid, suppresses papillomavirus E6 protein function, stabilizes p53 protein and induces apoptosis in cervical tumor cells. Mol. Carcinog.

Dimcheff, D., Volkert, L. G., Li, Y., DeLucia, A. L., and W.P. Lynch. 2006. Gene expression profiling of microglia infected by a highly neurovirulent murine leukemia virus: implications for neuropathogenesis. Retrovirology 3:26.

Ourednik, J., Ourednik, V., Lynch, W.P., Snyder, E.Y., and M. Schachner. 2002. Neuronal rescue by neural stem cells in a mouse model of Parkinson’s disease. Nat. Biotech.11:1103-10.

Traister, R. S. and W.P. Lynch. 2002. Re-examination of amphotropic murine leukemia virus neurovirulence: neural stem cell-mediated microglial infection fails to induce acute neurodegeneration. Virology 293:262-272.

Lynch, W.P. and J. L. Portis. 2000. Neural stem cells as tools for understanding retroviral neuropathogenesis. Virology 271:227-233.

Lynch, W.P. and A.H. Sharpe. 2000. Differential glycosylation of the Cas-Br-E Env protein is associated with retrovirus-induced spongiform neurodegeneration. J. Virol. 73: 1558-1565.