Summer Research Fellowship Program
Sheila Fleming, P.hD.
Gene-Environment Interactions in Parkinson’s Disease
The goal of these studies is to understand the role of ATP13A2 in cellular dysfunction and neurodegeneration. The objective is to characterize ATP13A2 x environmental exposure interactions and determine the mechanisms by which they contribute to behavioral dysfunction and neurodegeneration in vivo.
Denise Inman, Ph.D.
Dendritic arbor and synapse alterations in glaucoma-related neurodegeneration
The goal of these studies is to determine the mechanism by which dendrites and synapses are maintained during glaucoma pathology.
The objective of these proposed studies is to evaluate RGC dendrites and synapses from retinas of mice with glaucoma who are fed either a ketogenic diet or normal chow. Once we observe any changes in dendritic arbors or synapse number in mice on the ketogenic diet, then we will determine if those changes occurred as a result of mTORC1 activity.
Takhar Kasumov, Ph.D.
The role of post-translational acetylation in hepatic mitochondrial dysfunction in non-alcoholic fatty liver disease
We will apply mass spectrometry-based immunoprecipitation proteomics to determine whether acetylation-induced modification of hepatic mitochondrial proteins leads to their reduced stability and dysfunction in a high-fat diet- induced NAFLD in LDLR-/- mice, a diet-induced mouse model of NAFLD. The objective of this project is to efficiently enrich acetylated mitochondrial proteins from mice liver (aim 1), quantify acetylation and NAD+ levels in hepatic mitochondria samples (aim 2), and investigate the effect of this modification on mitochondrial function and stability (aim 3)
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