Summer Research Fellowship Program
Integrative Medical Sciences
Yeong-Renn Chen, Ph.D.
Cardiac metabolism in the disease of chronic myocardial infarction and heart failure
The objectives of this research are to assess the role of metabolic switch in the pathogenesis of chronic myocardial infarction and to explore new insights into the specific disease biomarker of mitochondria in order to more fully understand the mechanisms of cardiovascular disease. As metabolic syndrome associated FAO downregulation in the mitochondria is likely to have an impact on fuel homeostasis in myocardium, it is desirable to obtain further information on how metabolic switch affects the function of mitochondria, overall cardiac function, and regulation of the heart remodeling and related pathogenesis of heart failure development. To partially address this issue in 8 weeks and optimize the efficacy of summer fellowship training in biomedical research, the proposed studies have been designed to narrow the scope of investigation focusing on the mapping the metabolic pathways of FAO and GO in the mitochondria from the disease model of chronic myocardial infarction using proteomic approach.
William Chilian, Ph.D.
The Role of Bone Marrow Derived Stem Cells in Coronary Collateral Growth
The goal of this summer research is to determine if recruitment of bone marrow-derived stem cells is critical for coronary collateral growth. For this area to advance it is important to decipher the role of BMCs in this adaptive process.
William Chilian, Ph.D.
The Mechanism of Coronary Microvascular Insufficiency in Takotsubo Syndrome
The goal of this summer research is to test the hypotheses that cardiac myocytes in the apex and in the base of the left ventricle produce a different compliment (amount and type) of vasodilators. We believe this will explain the regional differences in microvascular function that occur in Takotsubo Syndrome in Kv1.5 null mice. We currently have all the resources necessary for this project, and believe the goal is attainable over the course of the summer.
Vahagn Ohanyan, M.D., Ph.D.
Doxorubicin-induced cardiomyopathy: Prevention and treatment by a coronary specific vasodilator.
The goal of this summer research is to test the hypothesis that heart failure occurring after Doxorubicin treatment is caused by microvascular dysfunction. We will test whether Chromonar treatment will prevent and reverse the consequences of doxorubicin treatment. We currently have all the resources necessary for this project, and believe the goal is attainable over the course of the summer.
Charles Thodeti, Ph.D.
Regulation of VEGFR2 localization and activation in tumor angiogenesis by a mechanosensitive ion chennel, TRPV4
The goal will be to determine the molecular mechanism by which TRPV4 channels regulate VEGFR2 localization and activation in response to tumor matrix stiffness. To achieve this, we will use cultured normal and TRPV4 null endothelial cells (human and mouse) and specific activators/inhibitors of TRPV4 and VEGF/VEGFR2.