{"id":7317,"date":"2024-04-15T13:34:27","date_gmt":"2024-04-15T17:34:27","guid":{"rendered":"https:\/\/www.neomed.edu\/pharmacy\/?page_id=7317"},"modified":"2025-11-03T16:20:59","modified_gmt":"2025-11-03T21:20:59","slug":"fleming-lab","status":"publish","type":"page","link":"https:\/\/www.neomed.edu\/pharmacy\/pharmsci\/fleming-lab\/","title":{"rendered":"Fleming Lab"},"content":{"rendered":"

[vc_row content_width=”full” page_header_style=”normal” css=”.vc_custom_1713293111862{margin-bottom: 0px !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}” el_class=”block-a”][vc_column][vc_row_inner css=”.vc_custom_1713293133775{margin-bottom: 0px !important;}”][vc_column_inner css=”.vc_custom_1713293083106{margin-bottom: 0px !important;}”][vc_raw_html]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[\/vc_raw_html][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row content_width=”full” el_class=”block-b”][vc_column][vc_row_inner el_class=”main-body”][vc_column_inner el_class=”sidebar” width=”1\/3″ css=”.vc_custom_1713289176498{padding-top: 200px !important;}”][vc_raw_html css=”.vc_custom_1713293171976{margin-bottom: 0px !important;}”]JTNDaW1nJTIwc3JjJTNEJTIyaHR0cHMlM0ElMkYlMkZ3d3cubmVvbWVkLmVkdSUyRndwLWNvbnRlbnQlMkZ1cGxvYWRzJTJGVU5JVl9IU19zaGVpbGEtZmxlbWluZy5qcGclMjIlMjBhbHQlM0QlMjIlMjIlMjB3aWR0aCUzRCUyMjMwMCUyMiUyMGhlaWdodCUzRCUyMjQwMCUyMiUyMGxvYWRpbmclM0QlMjJsYXp5JTIyJTNF[\/vc_raw_html][vc_column_text]<\/p>\n

Principal investigator<\/h4>\n

Sheila Fleming, Ph.D.<\/strong>
\nAssociate Professor of Pharmaceutical Sciences<\/span>
\nDirector, Neurodegenerative Disease and Aging Research Focus Area<\/a><\/span><\/p>\n

Full biography<\/a><\/p>\n

Contact<\/h4>\n

sfleming1@neomed.edu<\/a>[\/vc_column_text][vc_separator color=”custom” align=”align_left” el_width=”70″ accent_color=”#c1c1c1″][\/vc_column_inner][vc_column_inner width=”2\/3″][vc_column_text]<\/p>\n

Overview<\/h3>\n

The Fleming lab does research on multiple aspects of Parkinson\u2019s disease that range from identifying molecular mechanisms involved in the interaction of environmental and genetic factors in PD, to testing potential therapeutics (biologics, re-purposed drugs, and exercise therapy) in animal models, to developing a novel protocol for dance therapy for patients. At the core of each of these investigative areas is behavioral function because this is ultimately what we are trying to improve for patients.<\/p>\n

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Current work<\/h3>\n
    \n
  1. \"Dr.The effect of treadmill exercise in the alpha-synuclein preformed fibril rat model of Parkinson\u2019s disease<\/strong>: We find that exercise improves aspects of movement and cognition, and we are now working to extend this project to further investigate the effect of exercise on cognitive and neuropsychiatric function in the alpha-synuclein preformed fibril model of Parkinson\u2019s disease.<\/li>\n
  2. Gene x Environment interactions in Parkinsonism<\/strong>: We are currently investigating heavy metal exposure and genetic vulnerability on motor and cognitive function to determine how behavior deficits correlate with cellular dysfunction.<\/li>\n
  3. Developing a protocol to determine the effect of ballroom dance training on motor coordination and neuropsychiatric function<\/strong>: We are using motion capture equipment and software to measure coordination between partners during different ballroom dances.<\/li>\n<\/ol>\n
    \n

    Select funders<\/h3>\n

    1R01ES031124<\/strong>
    \n\u201cATP13A2 and susceptibility to neurodegeneration\u201d
    \nPI: Sheila Fleming, Ph.D.
    \nAgency: NIH\/ NIEHS
    \nThis grant will investigate how loss of ATP13A2 function affects manganese and alpha-synuclein toxicity in mice.<\/p>\n

    W81XWH-19-0772<\/strong>
    \n\u201cExercise effects on synuclein aggregation, neuroinflammation and neurodegeneration\u201d
    \nInitiating PI: Caryl Sortwell, Ph.D.
    \nPartnering PI: Sheila Fleming, Ph.D.
    \nAgency: Department of Defense, Biological mechanisms of impact from exercise on neurodegeneration in Parkinson\u2019s disease
    \nThis grant will determine the therapeutic efficacy of exercise in an optimized alpha-synuclein model of Parkinson\u2019s disease.<\/p>\n

    \n

    Open positions<\/h3>\n

    See any open positions in this lab on the NEOMED careers site<\/a>.<\/p>\n

    \n

    Video and story<\/h3>\n

    From Ignite<\/em> magazine: Showing the progression of Parkinson\u2019s Disease<\/a><\/p>\n

    In a Department of Defense-funded study, researchers in the Fleming Lab investigate the impact of exercise on Parkinson\u2019s pathology and cognitive dysfunction.[\/vc_column_text][vc_empty_space height=”50px”][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row content_width=”full” css=”.vc_custom_1688392540228{background-color: #f3f1e6 !important;}”][vc_column]

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