Integrated Pharmaceutical Medicine Graduate Program

Doctor of Pharmacy (Ph.D.) Course Descriptions

IPM 75001 – Transitions to Pharmaceutical Medicine (5 credits)

This course is designed for NEOMED professional students who are admitted into the dual M.D./Ph.D. or Pharm.D./Ph.D. program to help transition them from primarily a didactic learning environment to one that is problem solving with instruction by member of the graduate faculty. This course provides a grounding in research methods and experimental design that students will be able to apply directly to research undertaken as part of the course in an advisor’s lab. The concepts dealt with in class will be directly put into practice in the laboratory environment such that by the end of the course, the student has written up his/her research experience into a research paper and will present findings to the group. An additional component to the course will be an overview of pharmaceutical medicine from the perspective of the pharmaceutical industry.

IPM 75002 – Pharmaceutical Medicine Seminar (1 credit)

This seminar course has been structured as a “journal club” to provide students with a forum in which they read and discuss primary research that is broadly applicable to pharmaceutical medicine. Students are exposed to foundational concepts in research science, become comfortable discussing research science with their colleagues, and practice presenting scientific information to audiences. Students’ present primary research literature that all students are required to read and discuss. The course also includes attendance at the weekly seminar series for the department in which the student’s advisor resides.

IPM 75003 – Molecules to Cells (9.5 credits)

(Cross-listed with the College of Medicine, MST2-20214)
This course presents basic principles and fundamental concepts of biochemistry and genetics. Subjects include major metabolic pathways, properties of enzymes, cell biology, molecular pathology, and flow of genetic information and the control of gene expression. Clinical implications of alterations in these processes are integrated into the lecture material.

IPM 75004 – Pharmaceutical Research (1-10 credits)

This course provides Master’s degree and Ph.D. candidates the opportunity to earn research credit while building the skills and learning the techniques that will allow them to embark upon their thesis or dissertation research. This course is designed to be taken concurrently with didactic coursework and continuing beyond the completion of didactic coursework, but prior to Thesis Research or Dissertation Research. The Research course is taken with the student’s major advisor as the primary instructor. Master’s students in the Integrated Pharmaceutical Medicine program must have 15 credit hours of Research while Ph.D. students must have 30 credit hours of Research in order to fulfill the requirements of the program.

IPM 75005 – Human Development and Structure (10 credits)

(Co-scheduled with the College of Medicine, MST1-10101)
The course encompasses an integrated exploration of the human body from the level of gross anatomy to microscopic and submicroscopic anatomy. The normal and pathological development of the body from conception to birth is included in this survey. Contemporary medical imaging is used to explore the body from a clinical perspective. Throughout the course, the functional anatomy of body systems is emphasized, and appropriate examples of pathological processes are outlined.

IPM 75006 – Pharmaceutics with Lab (9.5 credits)

(Offered in conjunction with the College of Pharmacy, P1-61102)
This course introduces the pharmacy student to basic theory and principles applicable to functioning in a community pharmacy. There are two modules: 1) pharmaceutics and drug delivery systems and 2) pharmaceutics laboratory experience. In the first module, students will learn to formulate, design, compound and evaluate dosage forms and drug delivery systems needed for patient care. This module emphasizes the physiologic and drug formulation factors that influence extent and rate of drug release/absorption from various formulations. In the second module, students will learn the art of medication compounding in a laboratory setting. Dosage forms are prepared using patient profiles and appropriate auxiliary labels. Students will also learn important patient counseling points. The student is also introduced to the process of drug development and approval, including clinical trial descriptions.

IPM 75007 – Infection and Immunity for Pharmacists (8 credits)

(Co-scheduled with the College of Medicine, MST2-20102)
This interprofessional course is designed to provide the fundamental knowledge necessary for the proper management of diseases that are either totally microbiological/immunological in nature or that have a significant microbiological/immunological component. Infections and the host immune responses to them affect every body system and are important to every medical discipline. The structure and features of the microbe determine the nature of the infectious diseases that they cause. The innate and immune responses are the best defense against infection, but will often contribute or cause the tissue damage and symptoms of the disease. Sometimes the innate and immune responses are the sole cause of disease. Understanding the pathogen and the response to the pathogen is the basis for successful diagnosis and treatment of patients. It is necessary to both understand the general principles as well as know specific details in microbiology/immunology. The basic principles of this course supply the foundation for understanding the microbial disease process. The details about each microbe provide the specifics regarding the nature of the disease, means of identification, immune response, course of disease, treatment and prevention. Integrating the detail with the concepts will help the student learn the material better than just rote memorization of the factual details.

IPM 75008 – Principles of Drug-Body Interaction (6 credits)

(Offered in conjunction with College of Pharmacy, P2-62105)
This course introduces students to the relationship between drug design and the pharmacogenetics, metabolism and action of drugs; the influence of physical and chemical properties on structure-activity relationships; and the molecular, cellular, and physiologic basis of drug action. In addition, this course explores how the fate of drugs in the body is influenced by physiological and biochemical processes. Students learn methods to quantify parameters that affect absorption, distribution, metabolism, and excretion of drugs, and how to use those to formulate appropriate drug dosage regimens.

IPM 75011 – Physiological Basis of Medicine (4 credits)

(Offered in conjunction with the College of Medicine, IST2-20100)
The Physiological Basis of Medicine (PBM) course is designed to help students achieve an understanding of how the healthy cardiovascular, renal, respiratory, endocrine and gastrointestinal systems function. A student’s subsequent training will build on this foundation knowledge of normal organ function (physiology) to diagnose the causes of abnormal physiology (pathophysiology) and to pharmacologically (or surgically) return organ function toward normal. The purpose of PBM is to help student’s master normal physiology. Examples of disease (and pharmaceuticals used to treat them) will be used to demonstrate how various pathologies alter that organ function. Organ related case studies will further illustrate how pathologies alter normal function. Those case studies will also consider pharmacologic modification capable of returning that function to normal.

IPM 75019 – Medical Neuroscience (8 credits)

(Offered in conjunction with the College of Medicine, IST2-20101)
Medical Neuroscience is an 8-week course that introduces students to the central nervous system. We discuss structures and the circuits they form, how they develop, how they function normally and, to some extent, how they malfunction with disease, disorders or damage. Our audience includes first-year students in the College of Medicine as well as graduate students (master and doctoral) in Integrated Pharmaceutical Medicine (College of Graduate Studies, NEOMED) and Biomedical Sciences (Kent State University). A relatively small proportion of our students will go on to specialize in neuroscience-related areas, such as neurosurgery, neurology, psychiatry or behavioral sciences. Some of our students will likely pursue research, including clinical research in neuroscience areas or basic neuroscience research. However, the majority of our students will not be specializing in neuroscience but will care for patients who may turn to their health care provider for help in understanding what the “neuro” specialists are talking about. Medical Neuroscience provides the foundation for more specialized courses important for all our students. For those few who will specialize in neuroscience, Medical Neuroscience provides a first step toward deeper exploration of the relationships between the brain and its interactions with the world.

IPM 75082 – Systems Biology: Omics Tech (1 credits)

Systems Biology is a one semester faculty-mentored, integrated course that introduces the high-throughput technologies-based research in the fields of genomics, proteomics, metabolomics and fluxomics. The objectives of this course are to actively engage students in group discussions and training on applications of “omics” technologies to personalized medicine and drug discovery. The course heavily relies on out-of-class readings and learning through hands-on training on sample preparation, data analysis and outcome evaluation. In this inter-disciplinary course, we will focus on DNA/RNA sequencing, mass spectrometrybased proteomics and metabolomics. In addition, this course will introduce the fundamentals of mass spectrometry-assisted stable isotope-based metabolic studies with the main focus on metabolic fluxes that will be expanded to global fluxomics and pathways analyses. This course will be concluded with the introduction of multi-“omics” study design and data analysis. Students will be assigned three research papers for writing reports and presentations in teams. At the end of the course, students will be expected to give final oral presentation on an article related to multi-“omics” topics.

The overall goal of this introductory course is to provide the fundamental knowledge and training on different aspects of “omics” sciences- from data collection, data integration, to research applications, in addition to introducing basic bioinformatics tools for data analysis.

IPM 75101 – Independent Research Elective (1 credits)

(Intended for the PharmD-PhD student to earn IPM credit for Pharmacy research)
Professional electives in the College of Pharmacy at NEOMED offer students an array of opportunities to experience environments that allow immersion in unique and interesting segments of the profession of pharmacy (including research) and to develop a more specialized understanding of these chosen fields. In choosing their electives, students will draw upon skills acquired in didactic and experiential on-campus courses preceding the elective experience. Elective courses offer students enriched experiences and opportunities to enhance their depth of knowledge in a focused area that may direct their future career choice and will serve them throughout their professional lives.

IPM 75107 – Research Writing (2 credits)

Writing abstracts for conferences and research papers for publication is the cornerstone of disseminating experimental findings. This graduate level course provides the venue to develop and hone research-writing skills to communicate scientific information in a clear, accurate and persuasive manner. Scientific writing is unique in its point of view and voice (third person and passive); therefore, it requires practice to achieve. Given the investment, it would require of faculty to help students build this skill on an individual basis, the training this course will provide is of use to both faculty and students. This course is not designed to replace mentor-directed advice/teaching/guidance/training in writing, but to provide a foundation that will make this effort less painful and time consuming. In addition, it will organize students to be better prepared to consider positions in the private sector; e.g. in medical communications, clinical research or medical affairs, as well as in the academic arena. Good writing habits are a learned skill that require generating drafts/revisions and this basic principle is used throughout the course. There are no prerequisites.

IPM 5xx95, 6xx95, 7xx95 or 8xx95 – Special Topics in IPM (2-5 credits)

Special Topics courses are the designation given to courses either offered sporadically by faculty teaching a cohort of IPM students interested in the topic or taken at our partner universities through a consortium crossregistration agreement to fulfill requirements of the Integrated Pharmaceutical Medicine program. Different section identifiers are used when more than one special topics course is being offered in the same semester that has the same content, but different credit values or when offered by multiple partner institutions. Course titles are manually edited to describe section content to extent possible.

NEOMED-KSU Special Topics Cross-Registered Courses

IPM 75201 – KSU ST: Bioanthropology Data Analysis I (5 credits)

This course examines methods of univariate and bivariate experimental design. Emphasizes tests of hypothesis and estimation techniques with both classical and nonparametric procedures. (Course offered through KSU, Department of Anthropology, BMS 78687).

IPM 75095 – Cellular & Molecular Neuroscience (5 credits)

This course covers in depth the basic tenets of neuroscience and neural signaling in preparation for understanding neural function at a systems level. Topics include neurons and glia, molecular biology of channels and receptors, cellular neurophysiology, membrane potential and action potentials, synaptic transmission and integration, synaptic plasticity, nervous system development and patterning, synaptic connectivity, repair and regeneration, sexual differentiation, and neural aging. (Course offered through KSU, Department of Anatomy and Neurobiology, BMS 70729).

IPM 75195 – Molecular Cloning and Genetic Engineering (2 credits)

The goal of this course is to give students exposure to important, updated molecular techniques, and position them well for research experience and conceptual thoughts on experimental design. Covers the principals of basic recombinant DNA/Molecular cloning techniques and advanced techniques including cell reprogramming, RNA-seq, transgenic and knockout animal models (CRISPR) and Mass Spectrophometer. (Course offered through KSU, BMS 70251).

COGS 75400/75401 – Patient Care Connection (1 credit)

(Offered in conjunction with the College of Medicine)
Patient Care Connection is the clinical bridge for students who are engrossed in their PhD work after having finished at least their M2 year. The course is designed to keep the student up to date on basic physical exam and interviewing skills as well as clinical problem-solving skills.

IPM 75501 – Dissertation Research 1-15 credits (1-15 credits)

This course has been developed to provide doctoral candidates an opportunity to earn research credit toward performing research experiments, documenting their results, and performing data analyses that will form the basis of their dissertation work. This course is meant to be taken once the doctoral candidate has successfully defended his Prospectus, the dissertation plan. This course will be taken by the doctoral candidate every semester after the Prospectus defense and until the completion of the Dissertation defense. The credit hours assigned to this course can vary; however, doctoral students must have 15 credit hours of Dissertation Research in order to fulfill the requirements for a Doctor of Philosophy (Ph.D.) in the Integrated Pharmaceutical Medicine program. The maximum number of Dissertation Research credits a student can earn is 20.

Contact

Denise Inman, Ph.D.
Program Director
Phone: 330.325.3437
Email: dinman@neomed.edu

Integrated Pharmaceutical Medicine

College of Graduate Studies at NEOMED