Academic Title(s)

Assistant Professor of Pharmaceutical Sciences

Administrative Title(s)

Primary Graduate Faculty III College of Graduate Studies

Bio

Dr. Woo Shik Shin is a faculty member at NEOMED, College of Pharmacy, Department of Pharmaceutical Sciences. Dr. Shin started his journey in science from, Seoul National University, School of Medicine, where he earned an M.S. degree in Tumor biology and Clinical Oncology. Then went to the South Dakota State University for a second M.S. degree in Computer Science to learn about computational power and approaching them to solve biological problems. Dr. Shin received a Ph.D. from the University of Minnesota – Minneapolis, 2016. He did postdoctoral training at the University of California-Los Angeles, David Geffen School of Medicine, Department of Neurology. Over ten years of extensive research career within biology and computer-aided drug design work led to original research articles in peer-reviewed journals include Nature Chemistry, Nature Communication, Alzheimer’s Research & Therapy, and three U.S. patents, which planned to be commercialized in multiple pharma companies.

Area of Expertise/Research Interests

My laboratory is primarily interested in drug design and discovery, protein structure/function, computational chemical biology, and bioinformatics.

Recently, we have successfully established the motif-guided drug screening pipeline by using a computer-aided drug design (CADD) approach. By the application of computational pipeline, we focus on the development and optimization of well-balanced interdisciplinary methods from in silico model to the experimental approach targeting antibacterial, antiviral, anticancer, and neurological disorder therapies.

Educational Background

• Ph.D., Biomedical Informatics and Medicinal Chemistry, University of Minnesota, 2016
• M.S., Computer Science/Informatics, South Dakota State University, 2010
• M.S., Tumor Biology and Clinical Oncology, Seoul National University, S. Korea, 2006
• B.S., Bioscience, Hankuk University of Foreign Studies, S. Korea, 2004

Courses

• Pharmaceutical Sciences
• Pharmaceutical Bioinformatics
• Medicinal Chemistry

Awards

• P1 Teacher of The Year 2021, College of Pharmacy

Presentations

• “An Interdisciplinary Approach to the Challenge of Antibiotic Resistance”, Department of Biological and Chemical Sciences, NYIT, Old Westbury, NY (2020)
• “Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation”, Alzheimer Association International Conference (AAIC), July, 2019, Los Angeles, CA
• “Multidisciplinary Approach to Alzheimer’s Disease: A study on drug repurposing and delivery system from in silico model to in vivo test”, Department of Veterinary Medicine, Western University of Health Science, Pomona, CA (2018)
• “β-amyloid oligomers promote seeded tau aggregation in cells” Research Talk, Rosetta Conference, University of Washington, Seattle, WA (2017)
• “Combination antibacterial therapy (CAT) against β-lactam drug-resistance”, Department of Neurology, David Geffen School of Medicine, UCLA, CA (2016)

Publications

• Shin WS, Di J, Murray K, Sun C, Li B, Bitan G, Jiang L “Different amyloid-β self-assemblies have distinct effects on intracellular tau aggregation” Front. Mol. Neurosci. 12:268. doi: 10.3389/fnmol.2019.00268
• Shin WS, Di J, Cao Q, Li B, Seidler PM, Murray KA, Bitan G, Jiang L “Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation” Alzheimers Res Ther. 2019 Oct 18;11(1):86
• Qin Cao, Woo Shik Shin, Henry Chan, Bethany Dubois, Binsen Li, Michael Sawaya, Juli Feigon, Lin Jiang “Inhibiting Amyloid-ß cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design” Nature Chemistry Oct 2018 10.1038
• Shin WS, Bergstrom A, Xie J, Bonomo RA, Crowder MW, Muthyala R, Sham YY, “Discovery of 1-hydroxypyridine-2(1H)-thiones-6-carboxylic acid as a first-in-class low-cytotoxic nanomolar metallo β-lactamase inhibitor” ChemMedChem. 2017 Jun 7;12(11):845-849
• Kang CH, Shin WS, Yeo D, Lim W, Ji LL “Anti-inflammatory Effect Of Avenanthramides Via Nf-κB Pathways In C2c12 Skeletal Muscle Cells” Free Radic. Biol. Med. 2018 Jan 22. pii: S0891-5849(18)30030-3. doi: 10.1016