Faculty & Staff Directory

Patrick Kang Ph.D.

Patrick Kang, Ph.D.

Contact
Phone: 330.325.6534
Email: pkang1@neomed.edu

Office
Room: RGE-331

Academic Title(s)

Research Assistant Professor
Department of Integrative Medical Sciences

Area of Expertise/Research Interests

My research focuses on mitochondrial reactive oxygen species, bioenergetics and oxidative damage in diseases. I have extensive experience in the field of biochemistry, biophysics and biomedical sciences. Trained as a protein crystallographer, I am particularly interested in the protein structure, function and the regulation of post-translational modification. I employed a broad variety of tools and applied my knowledge to better understand the cardiovascular disease after the ischemia-reperfusion injury, specifically in free radical generation and its impacts on bioenergetics in the heart mitochondria. I have also extended my research into the study of inborn mitochondrial disorders. Induced pluripotent stem cells derived from mitochondrial disorder patients are reprogrammed as the disease model platform to explore the pharmacological and nutritional interventions. My goal is to utilize my research findings to directly improve the quality of lives of patients.

Educational Background

  • National Taiwan University, Taiwan B.S. Chemistry
  • The Ohio State University, OH Ph.D. Biochemistry
  • Northeast Ohio Medical University, OH Postdoctoral Researcher
  • Northeast Ohio Medical University, OH Research Assistant Professor

Presentations

  • Chen Y-R, Chen CL, Kang PT, and Jin Z “Differential Acetylation Mediates Import of Cytosolic SOD2 into Mitochondria and SOD2 Aggregation Associated With Physiological Hypertrophy in the Heart of SOD2-tg Mice” Circulation. 134:A17991. (2016)
  • Chen CL, Kang PT, Zhang L, and Chen Y-R “Differential Protein Acetylation Mediates Mitochondrial Localization and Pentameric Aggregation of SOD2 in the Murine Heart of SOD2-Tg” Free Radic Biol Med. 100:S138. (2016)
  • Kang PT, Chen CL, Lin P, Zhang L and Chen Y-R “Increased cysteine sulfonation of complex I, complex III, and aconitase is associated with mitochondrial dysfunction in the post-ischemic heart” The FASEB Journal 31:680.1. (2017)
  • Kang PT, Chen CL, Lin P, Paul and Chen Y-R “Increased Cysteine Sulfonation of Complex I Mediates Mitochondrial Dysfunction in the Post-Ischemic Rat Heart” Circulation. 136:A15092. (2017)
  • Kang PT, Chen CL, Lin P, Paul and Chen Y-R “Increased Cysteine Sulfonation of the Hydrophilic Domain of Complex I Mediates Mitochondrial Dysfunction in the Post-ischemic Heart” Free Radic Biol Med. 112:113-114. (2017)

Publications

  • Guarini G, Kiyooka T, Ohanyan V, Pung YF, Marzilli M, Chen YR, Chen CL, Kang PT, Hardwick JP, Kolz CL, Yin L, Wilson GL, Shokolenko IN, Dobson JG, Fenton R, and Chilian WM. “Impaired Coronary Metabolic Dilation In The Metabolic Syndrome Is Linked To Mitochondrial Dysfunction And Mitochondrial DNA Damage” Basic Res Cardiol. 111:29 (2016). (PMID: 27040114)
  • Guarini G, Kiyooka T, Ohanyan V, Pung YF, Marzilli M, Chen YR, Chen CL, Kang PT, Hardwick JP, Kolz CL, Yin L, Wilson GL, Shokolenko IN, Dobson JG, Fenton R, and Chilian WM. “Impaired Coronary Metabolic Dilation In The Metabolic Syndrome Is Linked To Mitochondrial Dysfunction And Mitochondrial DNA Damage” Basic Res Cardiol. 111:29 (2016). (PMID: 27040114)
  • Zhang L, Chen CL, Kang PT, Jin Z, Chen YR, “Differential protein acetylation assists import of excess SOD2 into mitochondria and mediates SOD2 aggregation associated with cardiac hypertrophy in the murine SOD2-tg heart” Free Radic Biol Med. 108:595-609 (2017). (PMID: 28433661)
  • Kang PT, Chen CL, Lin P, Chilian WM, Chen YR “Impairment of pH gradient and membrane potential mediates redox dysfunction in the mitochondria of the post-ischemic heart” Basic Res Cardiol. 112:36 (2017). (PMID: 28508960)
  • 16. Kang PT, Chen CL, Lin P, Zhang L, Zweier JL, Chen YR “Mitochondrial complex I in the post-ischemic heart: reperfusion-mediated oxidative injury and protein cysteine sulfonation.” J Mol Cell Cardiol. 121:190-204 (2018). (PMID: 30031815)
  • 17. Jassim AH, Coughlin L, Harun-Or-Rashid M, Kang PT, Chen YR, Inman DM. “Higher Reliance on Glycolysis Limits Glycolytic Responsiveness in Degenerating Glaucomatous Optic Nerve.” Mol Neurobiol. 56(10):7097-7112 (2019). (PMID: 30980229)

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