Academic Title(s)

• Professor of Biochemistry/Molecular Biology
• Research Associate Professor of Pharmacy Practice

Bio

A Ph.D. biochemist-molecular biologist with seventeen years of experience in recombinant DNA technology, protein purification, drug metabolism, cytochrome P450, Liver disease and inflammation. Proteins involved in the process of tumor promotion and signal transduction (protein kinase) as well as drug, steroid, lipid and eicosanoid metabolism (cytochrome P450) have been isolated and antibodies produced. Complementary DNA clones to these proteins have been isolated, sequenced, chromosomal mapped, transfected and expressed in eukaryotic and prokaryotic cells.

Cis- and trans- regulator elements to cytochrome P450 4 genes have also been analyzed. Extensive experience in drug metabolism with respect to human carcinogenesis and alteration in fatty acid metabolism.

Area of Expertise/Research Interests

To understand the process of inflammation in human disease and the significance of fatty acid Omega hydroxylase genes (CYP4) in regulating inflammation and fatty acid metabolism.

Educational Background

• B.A., Biology, Illinois College, 1973
• M.S., Development Biology – Toxicology, Loyola University, 1978
• Ph.D., Biology – Biochemistry, Illinois State University, 1981

Courses

• Molecules to Cells; Biochemical Metabolism, Molecular Biology, Diseases
• Hematology/Oncology
• Seminar in Cellular and Molecular Biology; Journal Club in Biochemistry, Biochemistry IV

Academic & Professional Activities

• American Association for the Advancement of Science
• American Chemical Society
• American Cancer Society
• American Society for Biochemistry and Molecular Biology
• American Society for Pharmacology and Experimental Therapeutics

Awards

• Medical student teacher of the year award
• Outstanding Graduate Student Award, Illinois State University, Normal, IL
• Phi Sigma Research Award, Illinois State University, Normal, IL
• Vice President of Phi Sigma Society, Illinois State University, Normal, IL
• Elected member of Graduate Student Advisory Committee, Illinois State University, Normal, IL

Distinctions

• M1/M2 medical school curriculum 2005-2016
• NEOMED Medical admission committee, 2016
• YSU admission and CAPP meeting 2016
• Advance Medical Admissions, NEOMED, 2016
• Advance Medical Admissions, NEOMED, 2016

Presentations

• Argonne National Laboratories, Argonne, Illinois
• 5th World Congress on Diabetes & Metabolism, November 3-5, 2014 at Las Vegas, USA by OMICS Group Inc.
• Abbott Laboratories, Waukegan, Illinois
• Argonne National Laboratories, Argonne, Illinois
• Hoffman La Roche, Nutley, New Jersey

Publications

• Increased ethanol-inducible cytochrome P450-2E1 and cytochrome P450 isoforms in exosomes of alcohol-exposed rodents and patients with alcoholism through oxidative and endoplasmic reticulum stress. Cho YE, Mezey E, Hardwick JP, Salem N Jr, Clemens DL, Song BJ. Hepatol Commun. 2017 Jul 13;1(7):675-690. doi: 10.1002/hep4.1066. eCollection 2017 Sep. PMID: 29404485.
• Hairy and enhancer of split 6 prevents hepatic lipid accumulation through inhibition of Pparg2 expression. Park JE, Lee M, Kim SC, Zhang Y, Hardwick JP, Lee YK. Hepatol Commun. 2017 Nov 8;1(10):1085-1098. doi: 10.1002/hep4.1120. eCollection 2017 Dec. PMID: 29404444 .
• Impaired coronary metabolic dilation in the metabolic syndrome is linked to mitochondrial dysfunction and mitochondrial DNA damage. Guarini G, Kiyooka T, Ohanyan V, Pung YF, Marzilli M, Chen YR, Chen CL, Kang PT, Hardwick JP, Kolz CL, Yin L, Wilson GL, Shokolenko I, Dobson JG Jr, Fenton R, Chilian WM. Basic Res Cardiol. 2016 May;111(3):29. doi: 10.1007/s00395-016-0547-4. Epub 2016 Apr 4. PMID: 27040114.
• Cytochrome P450 Function and Pharmacological Roles in Inflammation and Cancer. Preface. Hardwick JP. Adv Pharmacol. 2015;74:xv-xxxi. doi: 10.1016/S1054-3589(15)00047-2. No abstract available. PMID: 26233914.
• Translational Implications of the Alcohol-Metabolizing Enzymes, Including Cytochrome P450-2E1, in Alcoholic and Nonalcoholic Liver Disease. Song BJ, Akbar M, Jo I, Hardwick JP, Abdelmegeed MA. Adv Pharmacol. 2015;74:303-72. doi: 10.1016/bs.apha.2015.04.002. Epub 2015 Jun 27. Review. PMID: 26233911.