Research & Faculty

Neurodegenerative Disease & Aging Research

We are a collaborative team of researchers that focus on fundamental and translational research in neurodegeneration and conditions linked to the aging of the brain. Our mission is to discover, develop and validate biomarkers and therapeutic approaches for neurodegenerative diseases, including Parkinson’s and Alzheimer’s disease and glaucoma.

Our scientific focus is on early intervention and stopping the progression of neurodegeneration, improving quality of life and addressing health disparities.

Areas of Study

Research focused on removing toxins from the brain and reducing brain inflammation. Studying non-motor aspects of PD and repositioning of existing drugs to stop progression. Individual susceptibility and treatment.

Researching a relationship between Alzheimer’s Disease and genetic susceptibility and environmental exposures. Biomarker development for cognitive dysfunction. Studying the non-cognitive aspects of Alzheimer’s including bone loss and mood disorders.

Identifying early mechanisms of degeneration and ways to reduce inflammation. Studying mitochondrial dysfunction and autophagy.

Faculty Researchers

Associate Professor of Pharmaceutical Sciences
Graduate Faculty Advsg Status College of Graduate Studies
Phone: 330.325.6680
Email: scrish@neomed.edu

Dr. Crish joined the Pharmaceutical Sciences faculty in July, 2010. He received his Bachelor of Science in Biology from Baldwin-Wallace College, Berea, Ohio in 1996 and his Ph.D. in Neurobiology from the University of Illinois at Chicago, Chicago, Illinois in 2004.

His research is concerned with pre-apoptotic changes occurring in glaucoma. Recently, as in other age-related neurodegenerative disorders, there have been a number of studies suggesting that functional deficits and compartmentalized degeneration occur well before cell death in glaucoma. It is unclear how much these pathologies produce the clinical symptoms characteristic to this disease or how they relate to eventual cell body loss.

He’s most interested in exploring how defects in axonal transport, metabolism, and physiology 1) drive axonal and somatic degeneration, 2) correlate to loss of function, and 3) represent targets for interventions to improve outcome. This research will serve to better define glaucoma’s progression and allow the development of more effective treatments.

Assistant Professor of Pharmaceutical Sciences
Research Assistant Professor of Anatomy and Neurobiology
Graduate Faculty Member College of Graduate Studies
Phone: 330.325.6598
Email: ccrish@neomed.edu

Dr. Crish joined the Pharmaceutical Sciences faculty in June, 2012. She received her Bachelor of Arts in Psychology from Baldwin-Wallace College, Berea, Ohio in 1999 and her Masters in Psychology from University of Illinois at Chicago in 2003 and her Ph.D. in Neuroscience from Vanderbilt University in Nashville, Tennessee in 2008.

Her research centers on age-related degeneration in the central nervous system and how this impacts health and function of the rest of the body. Specifically, Dr. Crish is  interested in brain pathology associated with comorbid osteoporosis in Alzheimer’s disease, and how disruptions in the way the brain controls bone growth may predict Alzheimer’s risk. Additionally, she’s pursuing how estrogens in the brain may help protect neurons and prevent or delay bone loss and/or cognitive decline.

Assistant Professor of Pharmaceutical Sciences
Phone: 330.325.6568
Email: sfleming1@neomed.edu

Assistant Professor of Pharmaceutical Sciences
Phone: 330.325.6471
Email: mhossain@neomed.edu

Assistant Professor of Pharmaceutical Sciences
Graduate Faculty Member College of Graduate Studies
Phone: 330.325.6449
Email: dinman@neomed.edu

Dr. Inman joined the Pharmaceutical Sciences faculty in January 2011. She received her Bachelor of Science degree from Drexel University, Philadelphia, Pa.; and her Ph.D. in Neuroscience from University of Virginia, Charlottesville, Va..  Dr. Inman is an author of 14 articles in peer-reviewed journals, the recipient of 2 research grants and more than 27 abstracts/posters.

The Inman lab is interested in the mechanisms of neurodegenerative disease, especially as it pertains to interactions between neurons and glia. Our recent work has investigated the role of glia in the pathogenesis of glaucoma, the second leading cause of blindness in the US. We manipulate the expression of anti-oxidants in retinal glia to increase retinal ganglion cells resilience to oxidative stress.

In addition, we are following up on data that suggests there is a metabolic deficiency associated with glaucoma pathogenesis by analyzing mitochondria within neurons and glia of the visual pathway.

Finally, we also explore the relationship between retinal ganglion cell physiology and morphological change during the course of glaucoma.

Assistant Professor of Pharmaceutical Sciences
Phone: 330.325.6552
Email: tkasumov@neomed.edu

News & Stories

Contact

Samuel Crish II, Ph.D.
Interim Director, Neurodegenerative Disease & Aging Research Focus Area
Phone: 330.325.6680
Email:  scrish@neomed.edu

Neurodegenerative Disease & Aging Research

Research Focus Area at NEOMED