Denise M. Inman, Ph.D.
Dr. Inman joined the Pharmaceutical Sciences faculty in January 2011. She received her Bachelor of Science degree from Drexel University, Philadelphia, Pa.; and her Ph.D. in Neuroscience from University of Virginia, Charlottesville, Va.. Dr. Inman is an author of 14 articles in peer-reviewed journals, the recipient of 2 research grants and more than 27 abstracts/posters.
Ph.D. in Neuroscience University of Virginia, Charlottesville, VA.
B.S. in Biology, cum laude Drexel University, Philadelphia, PA.
The Inman lab is interested in the mechanisms of neurodegenerative disease, especially as it pertains to interactions between neurons and glia. Our recent work has investigated the role of glia in the pathogenesis of glaucoma, the second leading cause of blindness in the US. We manipulate the expression of anti-oxidants in retinal glia to increase retinal ganglion cells resilience to oxidative stress.
In addition, we are following up on data that suggests there is a metabolic deficiency associated with glaucoma pathogenesis by analyzing mitochondria within neurons and glia of the visual pathway.
Finally, we also explore the relationship between retinal ganglion cell physiology and morphological change during the course of glaucoma.
S. Baltan,* D.M. Inman,* C.A. Danilov, R.S. Morrison, D.J. Calkins, P.J. Horner. “Metabolic vulnerability disposes retinal ganglion cell axons to dysfunction in a model of glaucomatous degeneration.” Journal of Neuroscience 30(16):5644-52, 2010. *Co-first authors
S.D. Crish, R.M. Sappington, D.M. Inman, P.J. Horner, D.J. Calkins. "Distal axonopathy with structural persistence in glaucomatous neurodegeneration." Proceedings of the National Academy of Sciences USA 107 (11) 5196-5201, 2010.
T. Uo, J. Dworzak, C. Kinoshita, Y. Kinoshita, D.M. Inman, P.J. Horner, R.S. Morrison. “Drp1 levels constitutively regulate mitochondrial dynamics and cell survival in cortical neurons.” Experimental Neurology 218(2): 274-285, 2009.
B.P. Buckingham,* D.M. Inman,* W. Lambert, E. Oglesby, D.J. Calkins, M.R. Steele, M. L. Vetter, N. Marsh-Armstrong, P.J. Horner. “Progressive Ganglion Cell Degeneration Precedes Neuronal Loss in a Mouse Model of Glaucoma,” Journal of Neuroscience 28(11):2735-2744, 2008. *Co-first authors
A. Bosco,* D.M. Inman,* M.R. Steele, G. Wu, N. Marsh-Armstrong, D.J. Calkins, P.J. Horner, M.L. Vetter. “Minocycline reduces microglial activation and improves optic neuropathy in the DBA/2J mouse model of glaucoma,” Investigative Ophthalmology and Visual Science, 49(4):1437-1446, 2008. *Co-first authors
I. Soto, E. Oglesby, B.P. Buckingham, J.L. Son, E.D.O. Roberson, M.R. Steele, D.M. Inman, M.L. Vetter, P.J. Horner, N. Marsh-Armstrong “Retinal Ganglion Cells Downregulate Gene Expression and Lose Their Axons with the Optic Nerve Head in a Mouse Glaucoma Model,” Journal of Neuroscience, 28:548-561, 2008.
D.M. Inman and P.J. Horner. “Reactive non-proliferative gliosis predominates in a chronic mouse model of glaucoma.” Glia 55(9):942-953, 2007.
D.M. Inman, R.M. Sappington, P.J. Horner and D.J. Calkins. “Quantitative correlation of optic nerve pathology with ocular pressure and corneal thickness in the DBA/2 mouse model of glaucoma.” Investigative Ophthalmology and Visual Science, 47:986-996, 2006.
M. Steele, D.M. Inman, D.J. Calkins, P.J. Horner, M.L. Vetter. “Whole retinal microarray analysis of glaucoma in DBA/2 mice.” Investigative Ophthalmology and Visual Science, 47:977-985, 2006.
C. Fiore, D.M. Inman, S. Hirose, L.J. Noble, T. Igarashi, N.A. Compagnone. “Treatment with the neurosteroid dehydroepiandrosterone promotes recovery of motor behavior after moderate contusive spinal cord injury in the mouse.” Journal of Neuroscience Research, 75:391-400, 2004.
D.M. Inman and O. Steward. “Ascending sensory, but not other long-tract axons, regenerate into the connective tissue matrix that forms at the site of a spinal cord injury in mice.” The Journal of Comparative Neurology, 462:431-449, 2003.
D.M. Inman and O. Steward. “Physical size does not determine the unique histopathological response seen in the injured mouse spinal cord.” Journal of Neurotrauma, 20(1):33-42, 2003.
D.M. Inman, L. Guth, O. Steward. “Genetic influences on secondary degeneration and wound healing following spinal cord injury in various strains of mice.” The Journal of Comparative Neurology, 451(3):225-235, 2002.
O. Steward, P.E. Schauwecker, L. Guth, Z. Zhang, M. Fujiki, D. Inman, J. Wrathall, G. Kempermann, F.H. Gage, K.E. Saatman, R. Raghupathi, and T. McIntosh. “Genetic approaches to neurotrauma research: opportunities and potential pitfalls of murine models,” Experimental Neurology, 157(1):19-42, 1999.
- 2008: University of Washington, Ophthalmology Grand Rounds, “Neurodegeneration in Glaucoma: Insights from the DBA/2J Model.”
- 2007: Seattle University, “The Role of Glia in Glaucoma.”
- 2005: Northwest Association for Biomedical Research, “Stem Cells in Research: Promises and Pitfalls.”
- 2003: University of Washington, Neurosurgery Grand Rounds, “Regenerative Sprouting in a Mouse Model of SCI.”
- 2001: Miami Project to Cure Paralysis, University of Miami, “Wound Healing in the Spinal Cord.”
D.M. Inman, C. Lupien, P.J. Horner. "Manipulating glia to protect retinal ganglion cells in glaucoma." Glaucoma, In-tech Press, Dr. Pinakin Gunvant, editor, 2011.
- Association for Women in Science [Board Member], since 2010
- Association for Research in Vision and Ophthalmology, since 2004
- National Neurotrauma Society, since 1999
- Society for Neuroscience, since 1996