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Moses Oyewumi Ph.D.

Assistant Professor of Pharmaceutical Sciences

Pharmaceutical Sciences

 

Phone: (330)325-6669

Location: 'D-110'

moyewumi@neomed.edu

 

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Moses Oyewumi, B.Pharm., Ph.D.

Assistant Professor of Pharmaceutical Sciences

Dr. Moses Oyewumi is an assistant professor in the Department of Pharmaceutical Sciences at the Northeast Ohio Medical University (NEOMED) College of Pharmacy. Dr. Oyewumi earned his Ph.D. degree from the University of Kentucky in 2003 and completed post-doctoral training at the University of Kentucky and at the University of Iowa in 2005. Prior to joining NEOMED, Dr. Oyewumi was a scientist, Pharmaceutics R&D for four years in the pharmaceutical industry.

Education

2003: Ph.D., Pharmaceutical Sciences, University of Kentucky, Lexington, KY

1996: M.S., Pharmaceutics and Industrial Pharmacy, University of Ibadan, Nigeria

1990: Bachelor of Pharmacy, Ahmadu Bello University (ABU) Zaria, Nigeria

Professional Experience

2009-present: Assistant Professor of Pharmaceutical Sciences, Northeast Ohio Medical University College of Pharmacy, Rootstown, OH.

2005-2009: Scientist I & II, Emisphere Technologies, Inc, Tarrytown New York, NY.

2005: Post-doctoral Fellow, College of Pharmacy, University of Iowa, IA.

2004: Post-doctoral Fellow, Center for Pharmaceutical Sciences and Technology, University of Kentucky, KY.

Research and Development ExperienceDr. Moses Oyewumi in Lab

  • miRNA-based therapeutics;
  • Targeted delivery systems.
  • Advanced drug delivery systems.
  • Solid, liquid, & semi-solid formulation development.
  • Formulation and delivery of APIs of small molecules and macromolecules.
  • Encapsulation technologies.
  • Microemulsion, liposome and nanoparticle delivery systems.
  • Dosage forms characterization, stability studies & quality control (tablets, capsules, syrups, suspensions, creams, ointments, emulsions).
  • Clinical supply manufacture (cGMP).

Research Interests

  • Design, development and application of novel nanoparticulate/microparticulate delivery systems;
  • Assessment of novel drug delivery systems using in-vitro and in-vivo models;
  • Targeted drug delivery systems in cancer, neuroprotection and neurodegeneration;
  • Nasal drug delivery systems in CNS diseases; and
  • Oral delivery of macromolecules.

Intellectual Property/Patents

Oyewumi, M.O.,  Uddin, A.N. Majuru, S., Bender, L. "Valacyclovir Formulations." PCT Patent Application. WO/2009/012436,  May 2009.

Oyewumi, M.O., Uddin, A.N. Majuru, S. “Improved Acyclovir Formulations” PCT Patent Application. WO020517, October 2008.

Majuru, S., Oyewumi, M.O., Gurler, M.T. Gallium nitrate formulations. PCT Patent Application. WO/2008/003050. March, 2008.

Levchik, H., Oyewumi, M.O., Majuru, S., Bay, W. E; Liao, J., Dinh, S., Dhoot, N. Formulations for delivering insulin. PCT Patent Application WO/2007/121318. October, 2007.

Lab work

Awards

  • Elsevier Recognition for top ten most cited paper (2007).
  • Technical Excellence Award (2006), Emisphere Technologies Inc.
  • Productivity Team Award (2006), Emisphere Technologies Inc.
  • Team Award (2005), Emisphere Technologies Inc.
  • Student Travel Award (2002), AAPS, Pharmaceutics and Drug Delivery.
  • Glavinos Travel Award (2002), College of Pharmacy, University of Kentucky.
  • Travel Award (2001), Controlled Release Society.
  • Helton Travel Award (2001), College of Pharmacy, University of Kentucky.

Publications

Manickavasagam D and Oyewumi, M.O. Critical assessment of implantable drug delivery devices in glaucoma management. Journal of Drug Delivery. In-press. 2013.

Murthy V. S. N. Maddipatla, Daniel Wehrung, Chuan Tang, Weizheng Fan, Oyewumi, M.O. Toshikazu Miyoshi and Abraham Joy. Photoresponsive coumarin polyesters that show crosslinking and polymer chain scission properties. Macromolecules, 2013, doi: 10.1021/ma400584y.

Wehrung, D., Shuangyi Sun, Elaheh A. Chamsaz, Joy, A., Oyewumi, M.O. Biocompatibility and tolerability of a new class of photoresponsive alkoxyphenacyl-based polycarbonates.  J. Pharmaceutical Sciences, 102, 1650-1660, 2013. PMID: 23529816

Bi, L., Wehrung, D., Oyewumi, M.O. Contributory roles of innate properties of cetyl alcohol/gelucire nanoparticle matrix to antioxidant and anti-inflammatory activities of quercetin. Drug Delivery and Translational Research 3, 318-329, 2013, doi: 10.1007/s13346-013-0130-6.

Wehrung, D., Bi Li, Geldenhuys, W.J., Oyewumi, M.O. Antitumor efficacy and tolerability of systemically administered gallium acetylacetonate delivered via gelucire-stabilized nanoparticles. J. Biomedical Nanotechnology, 9, 1029-1040, 2013.

Wehrung, D., Geldenhuys, W.J., Oyewumi, M.O. Effects of gelucire content on stability, macrophage interaction and blood circulation of nanoparticles engineered from nanoemulsions. Colloid Surf. B: Biointerfaces 94: 259-265, 2012, PMID: 22386863.

Wehrung, D., Geldenhuys, W.J., Bi, L., Oyewumi, M.O. Biocompatibility, efficacy and biodistribution of gelucire-stabilized nanoparticles engineered for docetaxel delivery. J. NanoSci. Nanotechnol. 12, 2901-2911, 2012. PMID: 22755140.

Wehrung, D; Oyewumi, M.O. Antitumor effect of novel gallium compounds and efficacy of nanoparticle-mediated delivery in lung cancer. J. Biomed. Nanotech. 8, 161-171, 2012. PMID: 22515104.

    Oyewumi, M.O., Kumar, A., Cui, Z. Nano-microparticles as immune-adjuvants: correlating particle sizes and the resultant immune responses (invited article), 9, 1095-1107, 2010. PMID:20822351.

    Julian, T., Majuru, S., Oyewumi, M.O., Novick, S., Mangelius, M., Brown, B., Mehta, B., Warrell, P., Bender L. Phase 1 Assessment of an orally bioavailable formulation of gallium nitrate (4544). Blood, 11, 110: 4455 (2007).

    Oyewumi, M.O., Yokel, R.A., Jay, M., Coakley T., Mumper, R.J. Comparison of  cell uptake, biodistribution and tumor retention of folate-coated and PEG-coated gadolinium nanoparticles in tumor-bearing mice. Journal of Controlled Release 95: 613-626 (2004).

    Lockman, P.R., Oyewumi, M.O., Koziara, J., Roder, K., Mumper, R.J., Allen, D.D. Brain uptake of thiamine-coated nanoparticles. Journal of Controlled Release 93: 271-282 (2003).

    Oyewumi, M.O., Mumper, R.J. Influence of formulation factors on gadolinium entrapment and uptake using folate-coated nanoparticles. International Journal of Pharmaceutics 152: 85-97 (2003).

    Oyewumi, M.O., Liu, S., Moscow, J.A., Mumper, R.J. Specific association of thiamine-coated nanoparticles with human breast cancer cells expressing thiamine transporters. Bioconjugate Chemistry 14: 404-411 (2003).

    Mumper, R.J., Cui, Z., Oyewumi, M.O.  Nanotemplate engineering of cell specific nanoparticles. Journal of Dispersion Science and Technology 24: 569-588 (2003).

    Oyewumi, M.O., Mumper, R.J. Engineering tumor-targeted gadolinium hexanedione nanoparticles for potential application in neutron capture therapy. Bioconjugate Chemistry 13: 1328-1335 (2002).

    Oyewumi, M.O., Mumper, R.J. Gadolinium loaded nanoparticles engineered from microemulsion templates. Drug Dev. Industrial Pharmacy 28: 317-328 (2002).

    Lehmler, H-J., Oyewumi, M.O., Jay, M., Bummer, P.M.  Behavior of partially fluorinated carboxylic acids in the air-water interface. J. Fluorine Chemistry 107: 141-146 (2001).

    Book Chapters

    Majuru, S., Oyewumi, M.O. Nanotechnology in drug development and life cycle management. In “Nanotechnology in drug delivery”   Villers, D., Aramwit, M.N., Kwon, G.S. (Eds), Springer, New York (2008).

    Oyewumi, M.O., Rice, K.G. DNA nanoparticle gene delivery systems. In: “Nanoparticle technology for drug delivery”. Gupta, R.B; Kompella, U.B. (Eds) Taylor & Francis Group; Inc. (2006).

    Abstracts

    Wehrung, D. and Oyewumi, M.O. Nanoparticle entrapment of gallium acetylacetonate: biodistribution, antitumor efficacy and tolerability. Nanoflorida; University of South Florida; September 28-29, 2012.

    Wehrung, D. and Oyewumi, M.O. Cetyl Alcohol/Gelucire nanoparticles loaded with quercetin for antioxidant and anti-inflammatory applications. Nanoflorida; University of South Florida; September 28-29, 2012.

    Wehrung, D., Oyewumi, M.O. Nanoparticle-mediated delivery of novel gallium compounds facilitated tumor uptake and antitumor effects through transferrin-independent route. AAPS Annual Meeting, Washington DC, Oct 23-27, 2011.

    Bhatia, D., Wehrung, D., Oyewumi, M.O.  Liposomes for targeted delivery of bio-functional microRNA-34b for lung cancer treatment. AAPS Annual Meeting, Washington DC, Oct 23-27, 2011.

    Rettig, G. R., Oyewumi, M.O., Huang, Y., Rice, K.G. In-vitro gene transfer from a DNA-PEI loaded polylactide-glycolide porous sponge. 8th annual conference of American Association of Gene Therapy. St Louis, MO. June, 1-5, 2005.

    Jay, M., Zhu, D., Oyewumi, M.O., Mumper, R.J.  Tumor-targeted gadolinium nanoparticles for neutron capture therapy and for MRI contrast enhancement.  Nanoparticles, Colloids and Interfaces in Medical/Biochemical Diagnostic Applications Symposium at the Annual Colloid and Surface Science Symposium. Potsdam, New York. June 12-15, 2005.

    Oyewumi, M.O., Preparation and characterization of cell-specific nanoparticles for tumor and gene therapies. An invited presentation at Drake University, College of Pharmacy, Des Moines, IA. 2005.

    Oyewumi, M.O., Mumper, R.J. Biocompatibility and tumor-targeted delivery of folate-coated gadolinium nanoparticles in athymic mice. AAPS Annual Meeting, Salt lake City, Utah. October 26-30, 2003.

    Oyewumi, M.O., Mumper, R.J. Biodistribution of thiamine-coated nanoparticles in mice. AAPS Annual Meeting, Salt Lake City, Utah. October 26-30, 2003.

    Oyewumi, M.O., Mumper, R.J. Enhancement of gadolinium entrapment in nanoparticles engineered from microemulsion templates. AAPS Annual Meeting, Salt Lake City, Utah. October 26-30, 2003.

    Lockman, P.R., Oyewumi, M.O., Koziara, J., Roder, K.E., Mumper, R.J., Allen, D.D. Nanoparticles with thiamine surface ligands to target brain. AAPS Annual Meeting, Salt Lake City, Utah. October 26-30, 2003.

    Oyewumi, M.O., Mumper, R.J. Tumor-targeted delivery of folate-coated gadolinium nanoparticles in athymic nude mice. Proceedings of 30th International Symposium on Controlled Release of Bioactive Materials.  Glasgow, Scotland. July 19-23, 2003.

    Allen, D.D., Oyewumi, M.O., Koziara, J.M., Roder, K.E., Mumper, R.J., Lockman, P.R. Improved brain uptake of nanoparticles with thiamine surface ligands. Platform presentation. 5th International Conference of Cerebral Vascular Biology. Amarillo, Texas. June 03, 2003.

    Lockman, P.R. Oyewumi, M.O., Koziara, J.M., Roder, K.E. Mumper, R.J., Allen, D.D. Improved brain uptake of nanoparticles with thiamine surface ligands. Poster presentation. 5th International Conference of Cerebral Vascular Biology. Amarillo, Texas. June 03, 2003.

    Oyewumi, M.O., Cui, Z, Mumper, R.J. In-vitro tumor targeting of gadolinium nanoparticles via folate receptors. AAPS Annual Meeting, Toronto, Canada. November 10-14, 2002. AAPS PharmSci. 4, R6169, 2002.

    Oyewumi, M.O., Mumper, R.J. Gadolinium Hexanedione Nanoparticles Engineered for Potential Application in Neutron Capture Therapy of Tumors. 2002 Globalization of Pharmaceutics Education Network (GPEN) International Graduate Student Meeting. University of Michigan. Ann Arbor, Michigan. November 6-8, 2002.

    Oyewumi, M.O., Mumper, R.J. Engineering gadolinium hexanedione nanoparticles from microemulsions templates. Proceedings of the 29th International Symposium on Controlled Release of Bioactive Materials. Seoul, Korea. July 20-25, 2002.

    Oyewumi, M.O., Mumper, R.J. Folate-coated nanoparticles designed for tumor-targeted delivery of gadolinium. The 2nd International Symposium on Tumor-Targeting Delivery Systems sponsored by the Controlled Release Society and National Cancer Institute, NIH Campus, Rockville. September 22-25, 2002.

    Oyewumi, M.O., Mumper, R.J. Sterile and freeze-dried nanoparticles engineered from novel microemulsion templates. Proceedings of AAPS Pharmaceutics and Drug Delivery Conference. Arlington VA. April 22-24, 2002.