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Deepak Bhatia Ph.D.

Assistant Professor of Pharmaceutical Sciences

Pharmaceutical Sciences

 

Phone: (330)325-6482

Location: 'D-106'

dbhatia@neomed.edu

 

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Deepak Bhatia, B.Pharm., M.S., Ph.D.


Assistant Professor of Pharmaceutical Sciences

Dr. Bhatia joined the Pharmaceutical Sciences faculty in August 2008. He received his Bachelor of Pharmacy degree from Bangalore University, Bangalore, India; and his M.S. and Ph.D. in Pharmaceutical and Pharmacological Sciences from West Virginia University, Morgantown, W. Va.

Dr. Bhatia is an author of six articles in peer-reviewed journals, 10 abstracts/posters and 11 presentations.

Education

2007: Ph.D. in Pharmaceutical and Pharmacological Sciences, West Virginia University, W.Va.

2003: M.S. in Pharmaceutical and Pharmacological Sciences, West Virginia University, W.Va.

1999: B.Pharm., Bangalore University, Bangalore, India

Professional Experience

2008- present: Assistant Professor of Pharmaceutical Sciences, Northeastern Ohio Universities College of Pharmacy, Rootstown, Ohio

2007-2008: Postdoctoral Research Fellow, Beckman Research Institute, City of Hope, Duarte, Calif.

2006: Intern, Eli Lilly & Co., Indianapolis, Ind.

2003-2007: Fellow, Center for Disease Control & Prevention, Morgantown, W.Va.

2002-2004: Graduate Research Assistant, West Virginia University, W.Va.

2001-2002: Graduate Teaching Assistant, West Virginia University, W.Va.

Research Interests

The broad focus of my research  is to investigate genetics and epigenetics changes in human lung cancer in response to genotoxic stress. Occupational exposure to mammalian cells elicit a variety of stress-related signals that lead to the altered expression of multiple genes involved in cell-cycle control, programmed cell death, and in some case DNA repair. Interestingly, key growth-control genes, such as the tumor suppressors p53 and RB and transcription factors such as Egr-1, Nf-kB, play central roles in some of these signaling pathways, and perturbations in their function in many human tumor cells have important implications in carcinogenesis.

More interestingly, micro RNAs are also suggested to be involved in the regulating these genes which may act as oncogenic or tumor suppressor gene. Therefore, we aim to understand their function upon stress and ultimately use such genes and gene products as molecular genetic tools to employ novel "gene therapy" for the treatment of malignancies--notably lung cancer.

Research Focus

  • Genetic and epigenetic changes in lung cancer upon genotoxic stress – microRNA regulation, cell cycle check points, histone methylation
  • Chemo-preventive mechanism of  dietary agents
  • Free Radical Biology - Role of reactive oxygen and nitrogen species in cancer
  • Drug Delivery- functionalized nanoparticles and liposomes drug carriers for siRNA and miRNAs

Publications

Bishayee A, Bhatia D, Thoppil RJ, Darvesh AS, Nevo E, Lansky EP. “Pomegranate-mediated chemoprevention of experimental hepatocarcinogenesis involves Nrf2-regulated antioxidant mechanisms.” Carcinogenesis. 2011 Jun;32(6):888-96.

Mbimba T, Awale P, Bhatia D, Geldenhuys WJ, Darvesh AS, Carroll RT, Bishayee A. Alteration of Hepatic Proinflammatory Cytokines is Involved in the Resveratrol-Mediated Chemoprevention of Chemically-Induced Hepatocarcinogenesis. Curr Pharm Biotechnol. -- in press (2011).

Sutariya V, Miladore N, Geldenhuys W, Bhatia D, Wehrung D, Nakamura H. Thermoreversible gel for delivery of activin receptor-like kinase 5 inhibitor SB-505124 for glaucoma filtration surgery. Submitted to Pharmaceut Dev Tech 2011.

Bishayee A, Bhatia D, Darvesh AS, Nevo E, Lansky, EP. Pomegranate-mediated chemoprevention of experimental hepatocarcinogenesis involves Nrf2-regulated antioxidant mechanisms. Carcinogenesis. 2011 Mar 9. [Epub ahead of print] PubMed PMID: 21389260.

Mbimba T, Awale P, Bhatia D, Geldenhuys W, Darvesh AS, Caroll RT, Bishayee A. Alteration of hepatic proinflammatory cytokines is involved in the resveratrol-mediated chemoprevention of chemically-induced hepatocarcinogenesis. Curr Pharm Biotechnol, Oct;5(10):1613-8, 2010.

Bishayee A, Haznagy-Radnai E, Mbimba T, Sipos P, Morazzoni P, Darvesh AS, Bhatia D, Hohmann J. Anthocyanin-rich black current extract suppresses the growth of human hepatocellular carcinoma cells. Nat Prod Commun 5: 1613-1618, 2010.

Carroll RT, Bhatia D, Geldenhuys W, Bhatia R, Miladore N, Bishayee A, Sutariya V. Brain-targeted delivery of Tempol-loaded nanoparticles for neurological disorders. J Drug Target. 2010 Nov;18(9):665-74. PubMed PMID: 20158436.

Bishayee A, Háznagy-Radnai E, Mbimba T, Sipos P, Morazzoni P, Darvesh AS, Bhatia D, Hohmann J. Anthocyanin-rich black currant extract suppresses the growth of human hepatocellular carcinoma cells. Nat Prod Commun. 2010 Oct;5(10):1613-8. PubMed PMID: 21121259.

Bishayee A, Barnes KF, Bhatia D, Darvesh AS, Carroll RT. Resveratrol suppresses oxidative stress and inflammatory response in diethylnitrosamine-initiated rat hepatocarcinogenesis. Cancer Prev Res (Phila). 2010 Jun;3(6):753-63. Epub 2010 May 25. PubMed PMID: 20501860.

Bishayee A, Waghray A, Barnes KF, Mbimba T, Bhatia D, Chatterjee M, Darvesh AS. Suppression of the inflammatory cascade is implicated in resveratrol chemoprevention of experimental hepatocarcinogenesis. Pharm Res. 2010 Jun;27(6):1080-91. Epub 2010 Apr 20. PubMed PMID: 20405173.

Chang Q, Zhang Y, Beezhold KJ, Bhatia D, Zhao H, Chen J, Castranova V, Shi X, Chen F. Sustained JNK1 activation is associated with altered histone H3 methylations in human liver cancer. J Hepatol 50: 323-333, 2009.

Chang Q, Bhatia D, Zhang Y, Meighan T, Castranova V, Shi X, Chen F.  Incorporation of an internal ribosome entry site-dependent mechanism in arsenic-induced GADD45 alpha expression. Cancer Res 67: 6146-6154, 2007.

Chen F, Bhatia D, Chang Q, Castranova V. Finding NEMO by K63-linked polyubiquitin chain. Cell Death Differ 13: 1835-1838, 2006.

Zhang Y, Bhatia D, Xia H, Castranova V, Shi X, Chen F. Nucleolin links to arsenic-induced stabilization of GADD45alpha mRNA. Nucleic Acids Res 34: 485-495, 2006.

Abstracts/Posters

Bishayee A, Thoppil R, Darvesh AS, Bhatia D, Hohmann J.: Chemoprevention of hepatocellular carcinoma with anthocyanin-rich black currant (Ribes nigrum L.) extract: in vitro and in vivo evidence. 102th Annual Meeting of the American Association for Cancer Research, April 2-6, 2011, Orlando, FL.

Oyewumi O, Bhatia D: Anti-tumor effects of novel gallium (III) compounds and nanoparticle-based targeted delivery in lung cancer cells. AAPS Annual Meeting and Exposition, November 14-18, 2010, New Orleans, LA, USA.

Bishayee A, Bhatia D, et. al.: Resveratrol as a dietery chemopreventive agent against hepatocellular carcinoma: targeting NF-kappa B and NRF-2 signaling pathways. International Liver Cancer Association 4th Annual meeting 2010, September 9-12, 2010, Montreal, Canada.

Miladore N, Nakamura H, Geldenhuys W, Bhatia D, Sutariya V. Thermoreversible gel for delivery of activin receptor – like kinase 5 inhibitor in Glaucoma filtration surgery. The Association of research in vision and ophthalmology Annual meeting 2010, May 2-6, 2010, Fort Lauderdale, FL, USA

Waghrey A, Bishayee A, Barnes K, Lotey R, Darvesh A, Bhatia D, Carroll R. Mechanism of reseveratrol-mediated chemoprevention of hepatocellular carcinogenesis: suppression of oxidative stress and inflammation. Summer research fellowship program, September 21, 2009, NEOUCOM, Rootstown, OH, USA

Bhatia R, Carroll R, Geldenhuys W, Bhatia D, Miladore N, Sutariya V. Formulation of functionalized nanoparticles of tempol for brain targeted delivery for Parkinson’s disease. Summer research fellowship program, September 21, 2009, NEOUCOM, Rootstown, OH, USA

Chung A, Waghray A, Bishayee A, Sutariya V, Bhatia D. Arsenic sequentially activates ERK/ELK-1/Egr-1 in human bronchial pithelial (BEAS2B) cell lines. Summer research fellowship program, September 21, 2009, NEOUCOM, Rootstown, OH, USA

Miladore N, Nakamura H, Werner Geldenhuys, Bhatia D, Bhatia R, Sutariya V. Development of thermoreversible gel of SB505124 for suppression of ocular scarring after glaucoma filtration surgery. Summer research fellowship program, September 21, 2009, NEOUCOM, Rootstown, OH, USA

Bhatia R, Bhatia D, Geldenhuys W, Carroll R and Sutariya V. Brain targeted nanoparticles to selectively deliver Tempol to the mitochondria of compromised neurons in Parkinson's disease. 2nd Annual Nanotechnology Symposium, October 9-10, 2009, Sullivan University, Louisville, KY, USA

Bhatia R, Bhatia D, Geldenhuys W, Carroll R, Sutariya V. Development and optimization of brain targeted Tempol loaded nanoparticles for Parkinson’s disease. 3rd Ohio ACP Annual Meeting, October 9, 2009, Columbus, OH, USA

Bhatia D, Chung A, Bhatia R, Sutariya V, Chen F. The transcriptional regulation of Egr-1 upon arsenic insult in human bronchial epithelial (BEAS-2B) cells lines. AAPS Annual Meeting and Exposition, November 8-12, 2009, Los Angeles, CA, USA

Bhatia D, Chang Q, Xia H, Castronova V, Meghan T, Shi X, Chen F. Internal ribosome entry site (IRES) dependent regulation of GADD45a in arsenic induced stress response. 4th Conference on Molecular Mechanisms of Metal Toxicity and Carcinogenesis, September 24-27, 2006, Morgantown, WV, USA

Bhatia D, Hawkins E, Bauer S, Brozinick J. An in vivo method to overexpress the GLUT4 glucose transporter gene in rat skeletal muscle via electroporation. Intern Poster Day, July 27, 2006, Eli Lilly and Company, Indianapolis, IN, USA

Bhatia D, Chen F. Transcriptional and post-transcriptional regulation of Gadd45a in response to arsenic. Van Liere Convocation April 24-25, 2005, West Virginia University, Morgantown, WV, USA

Bhatia D, Haining RL. Immunoprecipitation of CYP2D from human brain for peptide-fingerprinting by MALDI-TOF mass spectrometry. 7th International ISSX Meeting, August 29-September 2, 2004, Vancouver, Canada

Bhatia D, Yu A, O’Callaghan JP, Miller DB, Gonzalez F, Haining RL. Does CYP2D6-humanization provide resistance to MPTP induced toxicity in mice? 12th North American ISSX Meeting, October 12-16, 2003, Providence, RI, USA

Presentations

Molecular mechanisms involved in induction of GADD45alpha by arsenic in human bronchial lung epithelial cells: Department of Hematopoietic Stem Cell and Leukemia Research, City of Hope Comprehensive Cancer Center, Duarte, CA on April 12, 2007.

Arsenic-mediated lung carcinogenesis: Department of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, CT on March 23, 2007.

Post-transcriptional regulation of GADD45alpha: Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA on March 12, 2007.

Possible link of CYP2D6-drug metabolizing enzyme in Parkinson’s disease: Department of Neurochemistry, Georgetown University Medical Center, Washington DC on March 7, 2007.

Internal ribosome mediated regulation of GADD45alpha: University of Pittsburgh Drug Discovery Institute, Pittsburgh, PA on March 2, 2007.

Regulation of Egr-1 in response to arsenic: Department of Medicine, University of Chicago, Chicago, IL on February 28, 2007.

Regulation of GADD45alpha in response to arsenic insult: Department of Thoracic, Head & Neck Medical Oncology, MD Anderson Cancer Center, University of Texas, Houston, TX on January 6, 2007.

ELK-1 mediated transcriptional activation of Egr-1 through MAPK pathways: Research in progress seminar at CDC/NIOSH, Morgantown, WV on April 19, 2006.

Signaling pathways involved in induction of GADD45alpha in response to arsenic: Research in progress seminar at CDC/NIOSH, Morgantown, WV on February 16, 2005.

Hepatic and extra-hepatic metabolism of psychoactive drugs by CYP2D6 and its variants: Department of Pharmaceutical and Pharmacological Sciences, West Virginia University, WV on January 29, 2004.

Cytochrome P450s in central nervous system: Department of Pharmaceutical and Pharmacological Sciences, West Virginia University, WV on March 13, 2003.

Intellectual Contributions

  • Ad Hoc Reviewer: Journal of Pharmaceutical Sciences
  • Ad Hoc Reviewer: Journal of Pharmaceutical Innovations
  • Ad Hoc Reviewer: AAPS PharmSciTech
  • Ad Hoc Reviewer: PLoS One
  • Ad Hoc Reviewer: Molecular Nutrition and Food Research
  • Abstract Reviewer: AAPS Annual Meeting 2009, Biotech Section
  • Editorial Board Member: Pharmaceutics & Novel Drug Delivery Systems: Current Research

Awards and Honors

  • Nominated member of The American Scholar National Honor Society, 2001
  • Fellowship Recipient, National Institute of Occupational Safety and Health (NIOSH) of Center for Disease Control (CDC), 2004-2007
  • Summer Research Fellowship - Summer Research Grant for Student 2009
  • Research Incentive Grant Ohio Board of Regents (ORB) - 2009; Role, Co-Investigator
  • Listed in Marquis Who’s Who in America; 2010 Ed.
  • Listed in  International Biographical Center, Cambridge, England

Professional Associations

  • International Society for the Study of Xenobiotics (ISSX): Past Member
  • The American Pharmacist Association (APhA): Past Member
  • American Association of College of Pharmacy (AACP): Current Member
  • The American Association of Pharmaceutical Scientists (AAPS): Current Member
  • The American Association of Indian Pharmaceutical Scientists (AAiPS): Current member
  • Sigma Xi, The Scientific Research Society, WVU Chapter: Current Member
  • American Society of Gene Therapy (ASGT): Current Member
  • American Association of Cancer Research (AACR): Current Member