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Thomas Jones Ph.D.

Assistant Professor of Pharmaceutical Sciences

Pharmaceutical Sciences

 

Phone: (330)325-6219

Location: 'C-102'

tjones4@neomed.edu

 

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Thomas J. Jones, Ph.D.

Assistant Professor of Pharmaceutical Sciences

Dr. Thomas J. Jones is an Assistant Professor in the Department of Pharmaceutical Sciences at the Northeastern Ohio Universities College of Pharmacy. Dr. Jones earned his Ph.D. from the Medical College of Ohio in 2004, completed a post-doctorate at The University of Pittsburgh, School of Pharmacy in 2004 and The University of Pittsburgh, School of Medicine in 2006.

Education

2004: Ph.D. (Molecular and Cellular Biology), Medical College of Ohio
1997: M.S. (Biology), The University of Akron, Ohio

Professional Experience

2012-present: Assistant Professor of Integrative Medical Sciences, Northeastern Ohio Universities College of Pharmacy, Rootstown, Ohio

2008-present: Assistant Professor of Pharmaceutical Sciences, Northeastern Ohio Universities College of Pharmacy, Rootstown, Ohio

2006-2008: Visiting Assistant Professor, College of Pharmacy, Department of Pharmacology, The University of Toledo

2004-2006: Post-doctorate, The University of Pittsburgh, School of Medicine, Pittsburgh, Penn.

2004: Post-doctorate, The University of Pittsburgh, School of Pharmacy, Pittsburgh, Penn.

Honors

Permanent Member, Peer Review Board: Journal of Visualized Experiments (JoVE)

Molecular Pahogenesis of Cancer Training Program

National Institutes of Health (2002-2003), Department of Biochemistry and Molecular Biology

Research Interests

My laboratory studies the extrarenal effects of primary cilia dysfunctions that are associated with polycystic kidney disease (PKD). We generally focus on the endothelium from various cilia mouse models (Tg737 and Pkd1).  The physiological implications focusing on the cardiovascular dysfunction observed in PKD. It is my assumption that primary cilia can mediate changes in proteins and organelles that control cellular metabolism, mediate growth and remodeling, and the cells response to inflammation (Glucocorticoid signaling). Thus, the focus of my research involves the investigation of Cilia Biology and steroid receptor signaling in the Development of Cardiovascular and endothelial dysfunctions in PKD.

Primary cilia are a once thought vestigial organelles that function like antenna extending out into the extra cellular fluid. These finger-like appendages expand the area of extracellular contact and provide an enriched signaling mechanism by which a cell can sense and be influenced by its environment. Their ability to function as a sensory organelle correlates with their ability to sense mechanical or chemical environmental cues. The sensory functions of cilia lead to the activation of multiple kinase pathways in addition to changes in eNOS and Ca+2 storage and release.

Publications

Jones TJ and Nauli SM (2011) Mechanosensory calcium signaling. Advances in Experimental Medicine and Biology (AEMB), Volume: 740: 1001-1016 (Book Chapter not cited in the SCI).

Jones, TJ, Adapala, RK, Geldenhuys, WJ, Bursley, C, Nauli, SM, and Thodeti, CK. (2010) Primary cilia regulates the directional migration and barrier integrity of endothelial cells through the modulation of hsp27 dependent actin cytoskeletal organization. Journal of Cellular Physiology - JCP-10-0659 (Accepted waiting for complete citation).

Tofovic SP, Jones, TJ, Bilan VP, Jackson, EK, Pertusevska, G, (2010) Synergistic Therapeutic Effects of 2-Methoxyestradiol with Either Sildenafil or Bosentan on Amelioration of Monocrotaline-Induced Pulmonary Hypertension and Vascular Remodeling J Cardiovasc Pharmacol. 2010 Nov;56(5):475-83

Tofovic SP, Jones TJ, Petrusevska G. (2010) Dose-dependent therapeutic effects of 2-Methoxyestradiol on Monocrotaline-Induced pulmonary hypertension and vascular remodelling. Prilozi. 2010 Jul;31(1):279-95.

Aboualaiwi WA, Takahashi M, Mell BR, Jones TJ, Ratnam S, Kolb RJ, Nauli SM. (2009) Ciliary Polycystin-2 Is a Mechanosensitive Calcium Channel Involved in Nitric Oxide Signaling Cascades. Circ Res. 2009 Mar 5. [Epub ahead of print]

Uppal H, Toma D, Saini SP, Ren S, Jones TJ, Xie W. (2004) Combined loss of orphan receptors PXR and CAR heightens sensitivity to toxic bile acids in mice. Hepatology. 2005 Jan;41(1):168-76.

Jones TJ, Li D, Wolf IM, Wadekar SA, Periyasamy S, Sanchez ER (2004) Enhancement of Glucocorticoid Receptor Transactivity by Constitutively-active Heat Shock Factor 1. Mol Endocrinol 2004 Mar;18(3):509-20.

Li DP, Periyasamy S, Jones TJ, Sanchez ER. (2000) Heat and chemical shock potentiation of glucocorticoid receptor transactivation requires heat shock factor (HSF) activity. Modulation of HSF by vanadate and wortmannin. J Biol Chem Aug 25;275(34):26058-65.

Jones TJ, Dunphy G, Milsted A, Ely D. (1998) Testosterone Effects on renal norepinephrine content and release in rats with different Y chromosomes. Hypertension Nov;32(5):880-5

Invited Presentations (National Meetings)

Jones T.J.  "Primary cilia induced changes in directional migration and barrier integrity through the modulation of HSP27." Kent State University, Biomedical Sciences Graduate Program, October 20, 2010. Invited by Robert Dorman, Ph.D.

Jones T.J.  "Cilia-mediated heat shock protein 27 (hsp27) suppression, a mechanism to modulate actin polymerization and organization in wild type mouse and oak ridge polycystickidney (ORPK) cells?" The University of Akron, Integrated Bioscience Ph.D. Program, January 29, 2009. Invited by Daniel Ely.

Jones TJ, Mell BR, Dokas LA, Yoder BK, Nauli SM. (2007) "Cilia-mediated heat shock protein 27 (hsp27) suppression modulates actin polymerization and organization in wild type mouse and oak ridge polycystic kidney (orpk) cells." The FASEB Journal (Experimental Biology 07), San Diego, CA.

Book Chapters

Jones TJ and Nauli SM (2011). Mechanosensory calcium signaling. Advances in Experimental Medicine and Biology (AEMB), Volume: 740: 1001-1016 (not cited in the SCI).

Abstracts

Jones TJ and Nauli SM (2011). Mechanosensory calcium signaling. Advances in Experimental Medicine and Biology (AEMB), Volume: 740: 1001-1016 (not cited in the SCI).

Jones, TJ, Adapala, RK, Geldenhuys, WJ, Bursley, C, Nauli, SM, and Thodeti, CK. (2010) “Primary cilia regulates the directional migration and barrier integrity of endothelial cells through the modulation of HSP-27 dependent actin cytoskeletal organization.” The FASEB Journal (Experimental Biology 2011), April 9 - 13, 2011, Washington DC (Poster).

Jones, TJ,  Adapala, RK, Geldenhuys, Nauli, SM, Bursley, C, Nauli, SM and Thodeti, CK. "Primary cilia regulates the directional migration and barrier integrity of endothelial cells through the modulation of HSP-27 dependent cytoskeletal organization." Submitted to Ohio Physiological society meeting,October 14 -15 2010, Cleveland OH.

Jones, TJ, Adapala, RK, Bursley, C, Nauli, SM, and Thodeti, CK. “Primary cilia regulates endothelial cell directional migration through HSP-27 dependent modulation of actin cytoskeleton and focal adhesions.” The FASEB Journal (Experimental Biology 2010), April 24-28, 2010, Anaheim, CA (Poster).

Cooper C, Jones, TJ. “A comparison of aortic endothelial cells isolated from polycystin1 knockout (Pkd1null/null) and cilia deficient (Tg737orpk/orpk) mice. Is cilia elongation necessary or is the ablation of the Polycystin 1 signaling pathway sufficient to modulate HSP-27 expression?” Office of Research and Sponsored Programs Poster Day Program 2009, NEOUCOM September 2, 2009.

Gallegos, PJ, Dzurec MA, Longstreth, KL, Jones, TJ, Peeters, MJ, McGory, R. “Pharmacy Students' Attitudes about Team-Based Learning in a Clinical Curricular Pharmacotherapy Module.” July 20, 2009 American Association of Colleges of Pharmacy meeting (Poster).

Gallegos, PJ, Jones, TJ, Longstreth, KL, Dzurec MA, Peeters, MJ. “Electronic versus Paper textbooks: where do students stand?” July 21, 2009 American Association of Colleges of Pharmacy meeting (Poster).

Takahashi, M, Mell, BM, AbouAlaiwi, WA, Jones, TJ, Ratnam, S, Kolb, RJ, Nauli, SM. “Differentiation of mechanical forces in perfused artery.” The FASEB Journal (Experimental Biology 09), April 18 - 22, 2009, New Orleans, LA (Poster).

Williams, FE, Jones, TJ, Hacker, MP, Hinko CN, Borovicka, M. "Distance-Learning Delivery of Functional Anatomy and Pathophysiology Lectures using Downloadable Video in UTCP Partnerships." (Submitted to American Association of Colleges of Pharmacy meeting Feburary 2008).

Jones TJ, Mell B.R., Dokas L.A., Yoder B.K., Nauli S.M. (Accepted 2007 #1153) "Cilia-mediated heat shock protein 27 (hsp27) suppression modulates actin polymerization and organization in wild type mouse and oak ridge polycystic kidney (orpk) cells." The FASEB Journal (Experimental Biology 07), San Diego, CA.

Jones TJ, Zhang X, Jackson EK, Tofovic SP. (2006) "Medroxyprogesterone acetate attenuates and tibolone prevents the development of monocrotaline-induced pulmonary hypertension." The FASEB Journal 2006 March 6;Vol 20(4):A402

Zhang X, Jones T, Jackson EK, Petrusevska G, Tofovic SP. (2005) 2-Methoxyestradiol attenuates the development and retards the progression of Chronic hypoxia-induced pulmonary hypertension in rats. Circulation 2005 Oct 25;(Supplement II) Vol 112(17):II-98

Jones TJ, Li D, Wolf IM, Wadekar SA, Periyasamy S, Sanchez ER (2003) "Stress potentiation of glucocorticoid receptor transactivity through HSF1-dependent and -independent pathways." 1st Annual Great Lakes Nuclear Receptor Conference, Toledo, OH.

Jones TJ, Sanchez ER (2003) "Evidence for a Stress-induced Factor that is Released from Cells and Enhances Steroid Responsiveness." The FASEB Journal (Experimental Biology 03), San Diego, CA.

Jones TJ, Wadekar SA, Wolf IM, Li D, Periyasamy S, Sanchez ER (2003) "Enhancement of Glucocorticoid Receptor Transactivity by Constitutively-Active Heat Shock Factor 1." 8th Annual Midwest Stress Response and Chaperone Meeting.

Jones TJ, Wolf I, Periyasamy S, Sanchez ER (2002) Stress-free "Potentiation of Glucocorticoid Receptor-mediated Gene Expression by Constitutively -active Heat Shock Factor 1." Keystone Symposia, Nuclear Receptor Superfamily (D4), Snowbird, UT.

Jones TJ, Wadekar SA, Li D, Periyasamy S, Sanchez ER (2001) "Potentiation of Glucocorticoid Receptor-mediated Gene Expression: The Role of  HSF1 Activation." 83rd Annual Meeting of The Endocrine Society Denver, CO.

Jones TJ, Dunphy G, Milsted A, Ely DL. (1997) "The effects of testosterone on norepinephrine (NE) levels in the perfused rat kidney." The FASEB Journal (Experimental Biology 97), New Orleans, LA.

Jones TJ, Dunphy G, Milsted A, Ely DL. (1997) "The effects of testosterone levels in the perfused rat kidney." The Ohio Academy of Science Journal.