Kenneth S. Rosenthal, Ph.D.

Professor of Microbiology, Immunology and Biochemistry
Department of Integrative Medical Sciences
College of Medicine

Education

Ph.D., Biochemistry, University of Illinois, Urbana, Illinois - 1977 

M.A., Biochemistry, University of Illinois, Urbana, Illinois - 1976 

B.S., Chemistry, University of Delaware, Newark, Delaware - 1973 

Professional Experience

Professor of Microbiology, Immunology and Biochemistry, Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, Ohio - 1991-Present 

Adjunct Professor, Course Director, Molecular Microbiology and Infectious Diseases, Florida International University, Herbert Wertheim Medical School, Miami Florida - 2008-present

Graduate Faculty, Biochemistry/Molecular Biology Area Committee (1979-1989); Cell Biology Area Committee (1979-1989); School of Biomedical Sciences (1989-present); Kent State University, Kent, Ohio - 1979-Present

Adjunct Associate Professor, University of Akron, Akron, Ohio - 1984-Present 

Adjunct Member, Graduate Faculty, Department of Chemistry, School of Graduate Studies, Youngstown State University, Youngstown, Ohio - 2002-Present 

Visiting Professor, Case Western Reserve University School of Medicine, Department of Biochemistry, Cleveland, Ohio - 1992-1993 

Associate Professor of Microbiology/Immunology, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio - 1984-1991

Director, Regional Cancer Resource Center Cancer Control Consortium of Ohio, Regions 7, 8, and 10 (N.E. Ohio, except Cuyahoga and Ashtabula Counties) - 1985-1986 

Academic Director, Regional Cancer Resource Center Cancer Control Consortium of Ohio, Regions 7, 8, and 10 (N.E. Ohio, except Cuyahoga and Ashtabula Counties) - 1983-1985 

Assistant Professor, Department of Microbiology/Immunology, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio - 1979-1984 

Adjunct Assistant Professor, University of Akron, Akron, Ohio - 1982-1984 

Research Fellow, Harvard Medical School, Department of Microbiology and Sidney Farber Cancer Center, Tumor Virology Department, Boston, Massachussets - 1977-1979 

Research Assistant, University of Illinois, Department of Biochemistry, Urbana, Illinois - 1974-1977 

Teaching Assistant, University of Illinois, Department of Chemistry/Biochemistry, Urbana, Illinois - 1973-1976 

Research Interests

• The interaction of herpes simplex virus (HSV) with its host leading to disease and immunity.
• Study of the biochemistry and cell biology of HSV glycoprotein synthesis, virion assembly and release.
• Study of the ICP34.5 gene and protein and its contribution to neuroinvasive disease (encephalitis).
• Study of the mode of action of the antiviral drugs, tromantadine and D609.
• Development of a heteroconjugate anti-HSV vaccine.
• Development of CEL-1000, an immunomodulating treatment for HSV and other infections.
• Use of flow cytometry in cell biological and immunological analysis.
• Development of a polymer device for transplantation and immunoisolation of porcine islet cells for treatment of Type I diabetes.

Patents

Patent: Conjugated Polypeptides for Treating Herpes Simplex Virus, Compositions and Vaccines Containing Same and Use Thereof for Treatment or Prevention of Herpes Simplex Virus and As Diagnostic Tool and In Diagnostic Kit.  Patent No. 6,572,860 B1.  Daniel H. Zimmerman and Kenneth S. Rosenthal.

Patent Pending: Methods for Treating Diseases or Conditions with Peptide Constructs.  Zimmerman, D.H., Charoenvit, Y., Rosenthal, K.S., Whelan, M.  Application No.: To Be Assigned.

Provisional Patent: Methods for Initiating Immunogenic Responses by Activating Dendritic Cells.  Kenneth S. Rosenthal, Daniel H. Zimmerman, Patricia R. Taylor Provisional Appln Ser. No.  61/169,034 filed April 14, 2009

Recent Publications

Dr. Rosenthal's publications listed in PubMed

Rosenthal, KS, Taylor PR, Zimmerman DH. 2011. J-LEAPS Peptide and LEAPS-Dendritic Cell Vaccines. Microbial Biotechnology. In Press

Walton CB, Jube S, Schorlemmer A, Patek PQ, Zimmerman DH, Rosenthal KS, Borthakur D. Ex vivo stimulation assay for T-cell responses for tuberculosis using LEAPS-peptide heteroconjugates. 2010. Curr Trends in Microbiology 6: 1-12.

P.R. Taylor, G.K. Koski, C.C. Paustian, E. Bailey, P.A. Cohen, F.B.-G. Moore,D.H. Zimmerman, K.S. Rosenthal. 2010.  J-LEAPS vaccines initiate murine Th1 responses by activating dendritic cells. Vaccine. 28: 5533–5542

DH. Zimmerman, PTaylor, ABendele, RCarambula, YDuzant, VLowe, SP O'Neill, E Talor and KS Rosenthal. 2010. CEL-2000: A Therapeutic Vaccine for Rheumatoid Arthritis Arrests Disease Development and Alters Serum Cytokine / Chemokine Patterns in the Bovine Collagen Type II Induced arthritis in the DBA Mouse Model. Intl Immunopharm. 10: 412-421

PR Taylor, CC Paustian, GK Koski, DH Zimmerman, KS Rosenthal. 2010. Maturation of dendritic cell precursors into IL12 producing DCs by J-LEAPS Immunogens. Cellular Immunology. 262: 1-5

Nazinitsky, Allison and Rosenthal, K.S.  2010.  Cytokine Storms: Systemic Disasters of Infectious Diseases.  Infect. Dis. in Clin. Prac. 18(3):188-192.

S Chatterjee, JW Wang, MJ Cismowski, JR Bower, KS Rosenthal. 2009. HSV-2 ICP34.5 protein modulates herpes simplex virus glycoprotein processing. Arch Virol  154:661–663

SF. Grundfest-Broniatowski , G Tellioglu, KS Rosenthal, J Kang, G Erdodi, B Yalcin, M Cakmak, J Drazba, A Bennett, L Lu, and J P Kennedy.  A new bioartificial pancreas utilizing amphiphilic membranes for the immunoisolation of porcine islets: a pilot study in the canine. ASAIO J. 2009 55(4):400-5.

J Brammer and KS Rosenthal. 2009.  Oncolytic Viruses: Therapeutic Smart Bombs. Infect Dis Clin Pract. 17:39-43

G Erdodi, J Kang,  B Yalcin,  M Cakmak, K S Rosenthal, S Grundfest-Broniatowski, J P Kennedy. 2009. A Novel Macroencapsulating Immunoisolatory Device: The Preparation and Properties of Nanomat-Reinforced Amphiphilic Conetworks Deposited on Perforated Metal Scaffold. Biomedical Microdevices. 11(1):297-312

S.Chatterjee, MJ Cismowski, KS Rosenthal. 2006. Sequence of HSV-2 strain 333 ICP34.5 gene published in the GenBank database (accession number DQ149924). Updated 2008.

Mao, H., Rosenthal, K.S. 2003.  Strain Dependent Structural Variants of Herpes Simplex Virus Type 1 ICP34.5 Determine Viral Plaque Size, Efficiency of Glycoprotein Processing and Viral Release and Neuroinvasive Disease Potential.  J. Virol.  77:3409-3417.

Storm, D.R., Rosenthal, K.S. and Swanson, P.E.  1977.  The Polymyxins and Related Peptide Antibiotics. Ann. Rev. Biochem. 46:723-763.

Articles

Rosenthal KS. Vaccines: All Things Considered – Eighth Annual GTCbio Conference, Washington DC, USA. IDDB MEETING REPORT  2010, November 8-9  2010. Thomson Reuters Pharma Report  Reference number RF1149930

Rosenthal, KS. THE GIFT THAT KEEPS GIVING: Herpes Simplex Virus. Physician License and Practice Today. Fall 2008

Zimmerman, D., Rosenthal, KS, Talor, E. 2007. The Vaccine Conundrum, 2007. The Scientist, 47-52.

Books and Book Chapters

RAPID REVIEWS OF MICROBIOLOGY AND IMMUNOLOGY, 3rd EDTION, (2010)  K.S. Rosenthal and  M.. Tan, Mosby, St. Louis  (Author and Editor).
RAPID REVIEWS OF MICROBIOLOGY AND IMMUNOLOGY, 2nd EDTION, (2006)  K.S. Rosenthal and J. Tan, Mosby, St. Louis  (Author and Editor). (translated into multiple languages)
RAPID REVIEWS OF MICROBIOLOGY AND IMMUNOLOGY, (2002) K.S. Rosenthal and J. Tan, Mosby, St. Louis (Author and Editor).

MEDICAL MICROBIOLOGY, 6th EDITION,  (2009). Ed., Murray, Rosenthal and Pfaller, Mosby, St. Louis, (Author and Editor, Basic Microbiology, Immunology and Virology Sections). (translated into multiple languages)
MEDICAL MICROBIOLOGY, 5th EDITION, (2005) Ed., Murray, Rosenthal and Pfaller, Mosby, St. Louis, (Author and Editor, Basic Microbiology, Immunology and Virology Sections). (translated into multiple languages)
MEDICAL MICROBIOLOGY, 4th EDITION, (2002) Ed., Murray, Rosenthal, Kobayashi, and Pfaller, Mosby, St. Louis, (Author and Editor, Basic Bacteriology, Immunology and Virology Sections).
MEDICAL MICROBIOLOGY, 3rd EDITION, (1997) Ed., Murray, Rosenthal, Kobayashi, and Pfaller, Mosby, St. Louis, (Author and Editor, Basic Microbiology, Immunology and Virology Sections).
MEDICAL MICROBIOLOGY, 2nd EDITION, (1993) Ed., Murray, Kobayashi, Pfaller and Rosenthal, Mosby, St. Louis, (Author and Editor, Virology Section).
MEDICAL MICROBIOLOGY, (1990) Ed., Murray, Drew, Kobayashi and Thompson, C.V. Mosby, St. Louis,  (Ten chapters in Virology).

MEDICAL MICROBIOLOGY AND IMMUNOLOGY FLASH CARDS, 2nd edition (2009) K.S. Rosenthal, Mosby, St. Louis, (Author).
MEDICAL MICROBIOLOGY AND IMMUNOLOGY FLASH CARDS, (2006) K.S. Rosenthal, Mosby, St. Louis, (Author). (Also translated into Chinese)

Basic Virology, in, PRACTICAL HANDBOOK OF MICROBIOLOGY 2^nd EDITION, (2008). Edited by Lawrence Green, CRC Press

REVIEW OF MEDICAL MICROBIOLOGY, (2005) P. Murray and K.S. Rosenthal, Mosby, St. Louis, (Author).

ACE the Boards Series: Microbiology/Immunology, (1996) K.S. Rosenthal and J. Tan, Mosby, St. Louis, (Author and Editor).

ORAL MICROBIOLOGY, (1992) Ed., Slots and Taubman, C.V. Mosby, St. Louis. Basic Virology, pp. 44-58, Viral Diseases, pp. 191-220.