Integrative Medical Sciences
Angelo L. DeLucia, Ph.D.
Associate Professor of Molecular Virology and Cancer Biology
Department of Integrative Medical Sciences
College of Medicine
Ph.D., Purdue University, West Lafayette, Ind. - 1981
B.S., John Carroll University, Cleveland, Ohio - 1975
Associate Professor, Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, Ohio - 1993-Present
Assistant Professor, Department of Microbiology and Immunology, Northeastearn Ohio Universities Colleges of Medicine and Pharmacy, Rootstown, Ohio - 1987-1993
Graduate Faculty, Kent State University, Kent, Ohio - 1987-Present
Post-doctoral Research Associate, Department of Microbiology, State University of New York, Stony Brook, N.Y. - 1981-1986
Graduate Student, Department of Biochemistry, Purdue University, West Lafayette, Ind. - 1975-1981
Laboratory and Lecture Assistant, Department of Chemistry, John Carroll University, Cleveland, Ohio - 1975
Research Assistant in Polymer Chemistry, B.F. Goodrich Research and Development Center, Brecksville, Ohio - 1974
My research studies are concerned with the understanding of how certain human papillomaviruses (HPVs) induce uterine cervical cancer, a major cause of women mortality worldwide. There are now known to be a number of other cancers associated with these viruses, such as head and neck tumors and various skin cancers. Uncontrolled expression of papillomavirus oncogenes may be the spark to ignite the process toward carcinogenesis. Specific topics of my investigation include molecular analysis of how HPV gene expression is regulated by viral and cellular transcription factors. This analysis includes study of a complex regulatory region within the viral genome that contains the major promoter and enhancer elements for the viral oncogenes called the E6 and E7 genes. Recently, in the process of exploring facets of the viral life cycle, we have discovered that a derivative of the plant lignan, nordihydroguaiaretic acid, has specific and potent inhibitory activity on HPV oncogene expression. Using these compounds, we should be able to reduce the levels of the viral E6 protein and thus interfere with a major route that leads to HPV- induced pre-cancerous and cancerous lesions. These results, with others, suggest that it may be possible to manipulate the p53 tumor suppressor pathway to induce cell cycle growth arrest and subsequently apoptosis of pre-cancer and cancer cells treated with the plant lignans or in combination with other drugs. In order to determine that we are inducing senescence and/or apoptosis, we are currently measuring telomerase activity within drug-treated cells, cell cycle regulatory proteins, and apoptosis pathway activation.
Jadhav R, Dodd T, Smith E, Bailey E, DeLucia AL, Russell JC, Madison R, Potter B, Walsh K, Jo H, Rocic P. Angiotensin type I receptor blockade in conjunction with enhanced Akt activation restores coronary collateral growth in the metabolic syndrome. Am J Physiol Heart Circ Physiol. 2011 May;300(5):H1938-49. Epub 2011 Feb 18.
Allen KL, Tschantz DR, Awad KS, Lynch WP, DeLucia AL. A plant lignan, 3'-O-methyl-nordihydroguaiaretic acid, suppresses papillomavirus E6 protein function, stabilizes p53 protein, and induces apoptosis in cervical tumor cells. Mol Carcinog. 2007 Jul;46(7):564-75.
Dimcheff, D.E., L.G. Volkert, Y. Li, A.L. DeLucia, and W.P. Lynch. 2006. Gene Expression Profiling of Microglia Infected by a Highly Neurovirulent Murine Leukemia Virus: Implication for Neuropathogenesis. Retrovirology 3:26-38.
Craigo, J., M. Callahan, R.C.C. Huang, A.L. DeLucia. 2000. Inhibition of Human Papillomavirus Type 16 Gene Expression by Nordihydroguaiaretic Acid Plant Lignan Derivatives. Antiviral Research 47:19-28.
Docherty, J.J., M.M. Fu, B.S. Stiffler, R.J. Limperos, C.M. Pokabla, A.L. DeLucia. 1999. Resveratrol Inhibition of Herpes Simplex Virus Replication. Antiviral Research 43:145-155.
DeLucia, A.L. Human Papillomavirus. R. Smith (ed.), Encyclopedia of AIDS. 1998. Fitzroy Dearborn Publ., Chicago.
Craigo, J., M. Hopkins, and A.L. DeLucia. 1995. Uterine Cervix Adenocarcinoma with Both Human Papillomavirus type 18 and Tumor Suppressor Gene p53 Mutation from a Woman Having an Intact Hymen. Gynecologic Oncology. 59:423-426.