Integrative Medical Sciences
Priya Raman, Ph.D.
Assistant Professor of Physiology and Pharmacology
Department of Integrative Medical Sciences
College of Medicine
Ph.D., Biochemical Pharmacology, University of Louisiana at Monroe, Monroe, Louisiana - 1999
M. Pharm., Pharmacology, Jadavpur University, Calcutta, India - 1992
B. Pharm., Pharmacy, Jadavpur University, Calcutta, India - 1990
Assistant Professor of Physiology and Pharmacology, Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, Ohio - 2009-Present
Graduate Faculty, Graduate School of Biomedical Sciences, Kent State University, Kent, Ohio - 2010-present
Project Scientist, Laboratory of Olga I. Stenina, Department of Molecular Cardiology, Cleveland Clinic, Cleveland, Ohio - 2008-2009
Research Associate, Laboratory of Olga I. Stenina, Department of Molecular Cardiology, Cleveland Clinic, Cleveland, Ohio - 2003-2008
Postdoctoral Fellow, Laboratory of Jeffrey S. Elmendorf, Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana - 2002-2003
Postdoctoral Research Associate, Laboratory of Michael E. Spurlock, Department of Animal Science, Purdue University, West Lafayette, Indiana - 2000-2002
Postdoctoral Research Fellow, Laboratory of Joseph s. Janicki, Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, Alabama - 1999-2000
Elucidation of cellular and molecular mechanism(s) of accelerated atherogenesis among diabetics is the primary focus of my research. In the light of the importance of obesity as an independent risk-factor for both diabetes and related vascular complications, my research program is two-fold: 1) regulation of vascular gene expression by adipokines to better comprehend the role of the adipose tissue in vascular diabetic complications, and 2) to explore the underlying MOA of antidiabetic agents implicated in diabetes and related vascular disorders. Currently, we are studying the role of thrombospondin-1 (TSP-1), a potent antiangiogenic and proatherogenic protein with strong implications in atherogenesis, in leptin-mediated macrovascular complications. We are using various approaches that involve cell and molecular biology, biochemistry and mouse models for these studies.
Ronaldo J Chavez, Rebecca M Haney, Rene H Cuadra, Rituparna Ganguly, Ravi K Adapala, Charles K Thodeti, and Priya Raman. (2012) Upregulation of Thrombospondin-1 Expression by Leptin in Vascular Smooth Muscle Cells via JAK2 and MAPK-dependent pathways. American Journal of Physiology Cell Physiology, published online before print May 16, 2012. doi: 10.1152/ajpcell.00008.
Vahagn A. Ohanyan, Giacinta Guarini, Charles K. Thodeti, Phani K. Talasila, Priya Raman, Rebecca Haney, J. Gary Meszaros, Derek S. Damron and Ian N. Bratz. (2011) Endothelin Mediated In Vivo Pressor Responses following TRPV1 Activation. AM J Physiol Heart Circ Physiol., Sep;301(3):H1135-42; published ahead of print June 24, 2011
Priya Raman, Christy Harry, Malory Weber, Irene Krukovets and Olga I. Stenina. (2011) A novel transcriptional mechanism of cell-type-specific regulation of vascular gene expression by glucose. Arteriosclerosis, Thrombosis and Vascular Biology 2011; 31: 634-642; published online Dec 9, 2010
Priya Raman, Irene Krukovets, Tina E. Marinic, Paul Bornstein and Olga I. Stenina. (2007) Glycosylation mediates upregulation of a potent antiangiogenic and proatherogenic protein, Thrombospondin-1, by glucose in vascular smooth muscle cells. Journal of Biological Chemistry 2007 Feb 23; 282(8):5704-14. Epub 2006 Dec 18.
This paper was featured in Science STKE “Editor’s choice”: Diabetes
Sugar-Coating the Road to Atherosclerosis,
Elizabeth M Adler (27 February 2007) Sci STKE 2007 (375), tw69.
The hexosamine pathway and the glycosylation of nuclear proteins may be a link between hyperglycemia and the development of atherosclerosis.
Gouli Chen*, Priya Raman*, Padma Bhonagiri, Andrew B. Strawbridge, Guruprasad R. Pattar and Jeffrey S. Elmendorf. (2004) Protective effect of phosphoinositol 4,5-bisphosphate against cortical filamentous actin loss and insulin resistance induced by sustained exposure of 3T3-L1 adipocytes to insulin. Journal of Biological Chemistry 279(38): 39705-9. *Both authors made substantial and equal contributions to this work.
Raman, P., Donkin, S.S. and Spurlock, M.E. (2004) Regulation of hepatic glucose metabolism by leptin in pig and rat primary hepatocyte cultures. Am J Physiol Regul Integr Comp Physiol. 2004 Jan; 286(1):R206-16.
Raman, P. and Judd, R.L. (2000) Role of glucose and insulin in thiazolidinedione-induced alterations in hepatic gluconeogenesis. European Journal of Pharmacology 409(1): 19-29.
Judd, R.L. and Raman, P. (1999) Pharmacological management of Type 2 diabetes mellitus: current and future therapies. Pharmacy Times 65(10): 85-94.
Raman, P. In: Encyclopedia of Toxicology (P. Wexler, Editor-In-Chief, Associate Editors: Gad, S.C., Hartung, R., Henderson, R.F., Krenzelok, Locey, B.J., Mehendale, H.M., Plaa, G.L., Pope, C.N., and Witschi, H.): Chlorothalonil, Chloropicrin, Captafol, DEF and Mevinphos (1998, 2005); Dinoseb, Dalapon (2005).
Raman, P., Foster, S.E., Stokes, M.C., Strenge, J.K. and Judd, R.L. (1998) Effect of troglitazone (Rezulin) on fructose 2,6-bisphosphate concentration and glucose metabolism in isolated rat hepatocytes. Life Sciences 62(8): PL 89-94.
Adams, M.D., Raman, P. and JUDD, R.L. (1998) Comparative effects of englitazone and glyburide on gluconeogenesis and glycolysis in the isolated perfused rat liver. Biochemical Pharmacology 55(11): 1915-1920.
Judd, R.L. and Raman, P. (1995) Metformin approved for non-insulin-dependent diabetes. Louisiana Medicaid Provider Update 12:4.