Priya Raman, Ph.D.
Assistant Professor of Physiology and Pharmacology
Department of Integrative Medical Sciences
College of Medicine
Ph.D., Biochemical Pharmacology, University of Louisiana at Monroe, Monroe, Louisiana - 1999
M. Pharm., Pharmacology, Jadavpur University, Calcutta, India - 1992
B. Pharm., Pharmacy, Jadavpur University, Calcutta, India - 1990
Assistant Professor of Physiology and Pharmacology, Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, Ohio - 2009-Present
Graduate Faculty, Graduate School of Biomedical Sciences, Kent State University, Kent, Ohio - 2010-present
Project Scientist, Department of Molecular Cardiology, Cleveland Clinic, Cleveland, Ohio - 2008-2009
Research Associate, Department of Molecular Cardiology, Cleveland Clinic, Cleveland, Ohio - 2003-2008
Postdoctoral Fellow, Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana - 2002-2003
Postdoctoral Research Associate, Department of Animal Science, Purdue University, West Lafayette, Indiana - 2000-2002
Postdoctoral Research Fellow, Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, Alabama - 1999-2000
Awards & Honors
Irvine H. Page Merit Award, Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, 2007.
Bernadine Healy Award, Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, 2005, 2006.
Outstanding Graduate Student Research Achievement Award, Division of Molecular Pharmacology, Northeast Louisiana University School of Pharmacy, Monroe, Louisiana, 1998.
Grants-in-Aid of Research Award, Sigma Xi National Honor Society, 1997.
Greenbaum Student Research Award in Pharmacology, Annual Meeting of the Southeastern Pharmacology Society, University of Mississippi (Oxford), 1996.
Junior Research Fellowship Award, University Grants Commission, Kolkata, India, 1990.
- Instructor and Co-Course Director: Physiological Basis of Medicine (M1/P1), 2011-Present.
- Instructor: Molecules to Cells (M1/P1), 2015-Present.
- Instructor and Co-Course Director: Clinical Epilogue and Capstone (M4), 2014-Present.
- Instructor: Principles of Medical Sciences (M2), 2010-Present.
- Instructor and Co-Course Director: Molecular Pharmacology (MS/PhD), 2013-Present.
- Instructor: Cell Signaling (MS/PhD), 2013-Present.
- Instructor: Microcirculation (MS/PhD), 2013-Present.
- Group Leader: Prologue (M1/P1), 2012-Present.
- Group Leader: Evidence-Based Medicine (M1/P1), 2011-Present.
- Group Leader: Practice-based Learning and Improvement (M3), 2013-Present.
Overall research focus in the Raman lab is in the area of Vascular Complications associated with Diabetes and Obesity. We are interested in understanding the cellular and molecular mechanisms underlying pathogenesis of accelerated atherosclerosis associated with hyperglycemia and hyperleptinemia, characteristics of diabetes, obesity and metabolic syndrome. Ongoing research projects in the lab include: 1) Role of the extracellular matrix protein, thrombospondin-1 (TSP-1) in vascular dysfunction associated with metabolic syndrome; 2) Role of leptin receptor signaling in hyperleptinemia-induced atherosclerosis complications; 3) Elucidation of mechanisms linking glucose metabolism to atherosclerosis; 4) Vasculoprotective mechanisms of the mineral nutrient trivalent chromium in diabetic vascular disease. For these studies, we utilize a variety of techniques including biochemical assays, cellular and molecular biology approaches and cell culture studies in conjunction with different in vivo mouse models of diabetes, obesity and atherosclerosis, including transgenic mouse lines and tissue-specific knockouts.
Selected Peer-Reviewed Publications (in chronological order)
Ronaldo J Chavez, Rebecca M Haney, Rene H Cuadra, Rituparna Ganguly, Ravi K Adapala, Charles K Thodeti, and Priya Raman. (2012) Upregulation of Thrombospondin-1 Expression by Leptin in Vascular Smooth Muscle Cells via JAK2 and MAPK-dependent pathways. American Journal of Physiology Cell Physiology, published online before print May 16, 2012. doi: 10.1152/ajpcell.00008.
Vahagn A. Ohanyan, Giacinta Guarini, Charles K. Thodeti, Phani K. Talasila, Priya Raman, Rebecca Haney, J. Gary Meszaros, Derek S. Damron and Ian N. Bratz. (2011) Endothelin Mediated In Vivo Pressor Responses following TRPV1 Activation. AM J Physiol Heart Circ Physiol., Sep;301(3):H1135-42; published ahead of print June 24, 2011
Priya Raman, Christy Harry, Malory Weber, Irene Krukovets and Olga I. Stenina. (2011) A novel transcriptional mechanism of cell-type-specific regulation of vascular gene expression by glucose. Arteriosclerosis, Thrombosis and Vascular Biology 2011; 31: 634-642; published online Dec 9, 2010
Priya Raman, Irene Krukovets, Tina E. Marinic, Paul Bornstein and Olga I. Stenina. (2007) Glycosylation mediates upregulation of a potent antiangiogenic and proatherogenic protein, Thrombospondin-1, by glucose in vascular smooth muscle cells. Journal of Biological Chemistry 2007 Feb 23; 282(8):5704-14. Epub 2006 Dec 18.
This paper was featured in Science STKE “Editor’s choice”: Diabetes Sugar-Coating the Road to Atherosclerosis, Elizabeth M Adler (27 February 2007) Sci STKE 2007 (375), tw69.
Ganguly R, Sahu S, Chavez RJ, Raman P. (2015) Trivalent chromium inhibits TSP-1 expression, proliferation and O-GleNAc signaling in vascular smooth muscle cells in response to high glucose in vitro. Am J Physiol Cell Physiol 2015 Jan 15;308(2):C111-22. doi: 10.1152/ajpcell.00256.2014. Epub 2014 Oct 29.
1. Raman, P., 2014. Captafol. In: Wexler, P. (Ed.), Encyclopedia of Toxicology, 3rd edition vol. 1. Elsevier Inc., Academic Press, pp. 655-658.
2. Raman, P., 2014. Chloropicrin. In: Wexler, P. (Ed.), Encyclopedia of Toxicology, 3rd edition vol. 1. Elsevier Inc., Academic Press, pp. 903-906.
3. Raman, P., 2014. Chlorothalonil. In: Wexler, P. (Ed.), Encyclopedia of Toxicology, 3rd edition vol. 1. Elsevier Inc., Academic Press, pp. 919-922.
4. Raman, P., 2014. DEF (Butyl Phosphorotrithloate). In: Wexler, P. (Ed.), Encyclopedia of Toxicology, 3rd edition vol. 1. Elsevier Inc., Academic Press, pp. 1150-1153.
5. Raman, P., 2014. Mevinphos. In: Wexler, P. (Ed.), Encyclopedia of Toxicology, 3rd edition vol. 3. Elsevier Inc., Academic Press, pp. 332-335
1. Soumyadip Sahu, Rituparna Ganguly, Vahagn Ohanyan, William M. Chilian, and Priya Raman (2014) Thrombospondin-1 plays a direct role in leptin-induced atherosclerosis. ATVB, Toronto, Canada, May 1-3, 2014.
2. Rituparna Ganguly, Soumyadip Sahu, Vahagn Ohanyan,, William M.Chilian, and Priya Raman (2014) Atheroprotective mechanism of chromium picolinate in streptozotocin-induced diabetic ApoE mice. ATVB, Toronto, Canada, May 1-3, 2014.
3. Rituparna Ganguly, Soumyadip Sahu, Brooke Boyer, and Priya Raman (2014) Chromium inhibits phenotypic switching of vascular smooth muscle cells in response to hyperglycemic conditions in vitro. Experimental Biology, San Diego, April 26-30, 2014.
4. Soumyadip Sahu, Ronaldo Chavez, Rituparna Ganguly, and Priya Raman (2013) Transcriptional mechanisms that mediate upregulation of thrombospondin-1 expression by leptin in vascular smooth muscle cells. Experimental Biology, Boston, April 20-24, 2013.
5. Priya Raman, Christy Harry, Malory Weber, Irene Krukovets, and Olga I. Stenina (2009) Cell-type specific regulation of thrombospondin-1 transcription by high glucose. Keystone Symposium-Complications of Diabetes and Obesity, Vancouver, BC, February 24-March 1, 2009.