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Priya Raman Ph.D.

Assistant Professor of Integrative Medical Sciences

Graduate Faculty Member College of Graduate Studies

Integrative Medical Sciences

 

Phone: (330)325-6425

Location: RGE-342

praman@neomed.edu

 

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Priya Raman, Ph.D.

Assistant Professor of Physiology and Pharmacology
Department of Integrative Medical Sciences
College of Medicine

Education

Ph.D., Biochemical Pharmacology, University of Louisiana at Monroe, Monroe, Louisiana - 1999

M. Pharm., Pharmacology, Jadavpur University, Calcutta, India - 1992

B. Pharm., Pharmacy, Jadavpur University, Calcutta, India - 1990

Professional Experience

Assistant Professor of Physiology and Pharmacology, Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, Ohio - 2009-Present 

Graduate Faculty, Graduate School of Biomedical Sciences, Kent State University, Kent, Ohio - 2010-present

Project Scientist, Laboratory of Olga I. Stenina, Department of Molecular Cardiology, Cleveland Clinic, Cleveland, Ohio - 2008-2009

Research Associate, Laboratory of Olga I. Stenina, Department of Molecular Cardiology, Cleveland Clinic, Cleveland, Ohio - 2003-2008

Postdoctoral Fellow, Laboratory of Jeffrey S. Elmendorf, Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana - 2002-2003

Postdoctoral Research Associate, Laboratory of Michael E. Spurlock, Department of Animal Science, Purdue University, West Lafayette, Indiana - 2000-2002

Postdoctoral Research Fellow, Laboratory of Joseph s. Janicki, Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, Alabama - 1999-2000

Research Interests

Overall research focus in the Raman lab is in the area of Vascular Complications associated with Diabetes and Obesity.  We are interested in understanding the cellular and molecular mechanisms underlying pathogenesis of accelerated atherosclerosis associated with hyperglycemia and hyperleptinemia, characteristics of diabetes, obesity and metabolic syndrome.  Ongoing research projects in the lab include:  1) Role of the extracellular matrix protein, thrombospondin-1 (TSP-1) in leptin-induced vascular dysfunction; 2) Role of leptin receptor signaling in hyperleptinemia-induced atherosclerosis complications; 3) Mechanisms linking glucose metabolism to pathogenesis of atherosclerosis.  For these students, we utilize a variety of techniques including biochemical assays, cellular and molecular biology approaches, cell culture studies in conjunction with different in vivo mouse models of diabetes, obesity and atherosclerosis, including transgenic mouse lines.

Peer-reviewed Publications

Rituparna Ganguly, Soumyadip Sahu, Ronaldo J. Chavez, Priya Raman.   (2014)  Trivalent Chromium Inhibits TSP-1 Expression, Proliferation and O-GleNAc signaling in Vascular Smooth Muscle Cells in Response to High Glucose in Vitro.  American Journal of Physiology - Cell Physiology Published October 29, 2014.  Volume No., DO1:  10,1152/ajpcell.00256.2014.

Ronaldo J Chavez, Rebecca M Haney, Rene H Cuadra, Rituparna Ganguly, Ravi K Adapala, Charles K Thodeti, and Priya Raman.  (2012)  Upregulation of Thrombospondin-1 Expression by Leptin in Vascular Smooth Muscle Cells via JAK2 and MAPK-dependent pathways.  American Journal of Physiology Cell Physiology, published online before print May 16, 2012.  doi: 10.1152/ajpcell.00008.

Vahagn A. Ohanyan, Giacinta Guarini, Charles K. Thodeti, Phani K. Talasila, Priya Raman, Rebecca Haney, J. Gary Meszaros, Derek S. Damron and Ian N. Bratz. (2011)  Endothelin Mediated In Vivo Pressor Responses following TRPV1 Activation. AM J Physiol Heart Circ Physiol., Sep;301(3):H1135-42; published ahead of print June 24, 2011

Priya Raman, Christy Harry, Malory Weber, Irene Krukovets and Olga I. Stenina. (2011)  A novel transcriptional mechanism of cell-type-specific regulation of vascular gene expression by glucose. Arteriosclerosis, Thrombosis and Vascular Biology 2011; 31: 634-642; published online Dec 9, 2010

Priya Raman, Irene Krukovets, Tina E. Marinic, Paul Bornstein and Olga I. Stenina. (2007)  Glycosylation mediates upregulation of a potent antiangiogenic and proatherogenic protein, Thrombospondin-1, by glucose in vascular smooth muscle cells. Journal of Biological Chemistry 2007 Feb 23; 282(8):5704-14. Epub 2006 Dec 18.

This paper was featured in Science STKE “Editor’s choice”: Diabetes 
Sugar-Coating the Road to Atherosclerosis,
Elizabeth M Adler (27 February 2007) Sci STKE 2007 (375), tw69.
The hexosamine pathway and the glycosylation of nuclear proteins may be a link between hyperglycemia and the development of atherosclerosis.

Gouli Chen*, Priya Raman*, Padma Bhonagiri, Andrew B. Strawbridge, Guruprasad R. Pattar and Jeffrey S. Elmendorf. (2004)  Protective effect of phosphoinositol 4,5-bisphosphate against cortical filamentous actin loss and insulin resistance induced by sustained exposure of 3T3-L1 adipocytes to insulin. Journal of Biological Chemistry 279(38): 39705-9.  *Both authors made substantial and equal contributions to this work.

Raman, P., Donkin, S.S. and Spurlock, M.E. (2004) Regulation of hepatic glucose metabolism by leptin in pig and rat primary hepatocyte cultures. Am J Physiol Regul Integr Comp Physiol. 2004 Jan; 286(1):R206-16.

Raman, P. and Judd, R.L. (2000) Role of glucose and insulin in thiazolidinedione-induced alterations in hepatic gluconeogenesis. European Journal of Pharmacology  409(1): 19-29.

Judd, R.L. and Raman, P. (1999) Pharmacological management of Type 2 diabetes mellitus: current and future therapies. Pharmacy Times 65(10): 85-94.

Raman, P.  In: Encyclopedia of Toxicology (P. Wexler, Editor-In-Chief, Associate Editors: Gad, S.C., Hartung, R., Henderson, R.F., Krenzelok, Locey, B.J., Mehendale, H.M., Plaa, G.L., Pope, C.N., and Witschi, H.): Chlorothalonil, Chloropicrin, Captafol, DEF and Mevinphos (1998, 2005); Dinoseb, Dalapon (2005).

Raman, P., Foster, S.E., Stokes, M.C., Strenge, J.K. and Judd, R.L. (1998) Effect of troglitazone (Rezulin) on fructose 2,6-bisphosphate concentration and glucose metabolism in isolated rat hepatocytes. Life Sciences 62(8): PL 89-94.

Adams, M.D., Raman, P. and JUDD, R.L. (1998) Comparative effects of englitazone and glyburide on gluconeogenesis and glycolysis in the isolated perfused rat liver. Biochemical Pharmacology 55(11): 1915-1920.

Judd, R.L. and Raman, P. (1995)  Metformin approved for non-insulin-dependent diabetes. Louisiana Medicaid Provider Update 12:4.

Book Chapters

1.  Raman, P., 2014.  Captafol. In:  Wexler, P.  (Ed.), Encyclopedia of Toxicology, 3rd edition vol. 1. Elsevier Inc., Academic Press, pp. 655-658.
2.  Raman, P., 2014.  Chloropicrin. In:  Wexler, P. (Ed.), Encyclopedia of Toxicology, 3rd edition vol. 1. Elsevier Inc., Academic Press, pp. 903-906.
3.  Raman, P., 2014.  Chlorothalonil.  In:  Wexler, P. (Ed.), Encyclopedia of Toxicology, 3rd edition vol. 1. Elsevier Inc., Academic Press, pp. 919-922.
4.  Raman, P., 2014.  DEF (Butyl Phosphorotrithloate).  In:  Wexler, P. (Ed.), Encyclopedia of Toxicology, 3rd edition vol. 1. Elsevier Inc., Academic Press, pp. 1150-1153.
5.  Raman, P., 2014.  Mevinphos.  In:  Wexler, P. (Ed.), Encyclopedia of Toxicology, 3rd edition vol. 3.  Elsevier Inc., Academic Press, pp. 332-335

Selected Abstracts

1.  Soumyadip Sahu, Rituparna Ganguly, Vahagn Ohanyan, William M. Chilian, and Priya Raman (2014)  Thrombospondin-1 plays a direct role in leptin-induced atherosclerosis.  ATVB, Toronto, Canada, May 1-3, 2014.

2.  Rituparna Ganguly, Soumyadip Sahu, Vahagn Ohanyan,, William M.Chilian, and Priya Raman (2014) Atheroprotective mechanism of chromium picolinate in streptozotocin-induced diabetic ApoE mice.  ATVB, Toronto, Canada, May 1-3, 2014.

3.  Rituparna Ganguly, Soumyadip Sahu, Brooke Boyer, and Priya Raman (2014) Chromium inhibits phenotypic switching of vascular smooth muscle cells in response to hyperglycemic conditions in vitro.  Experimental Biology, San Diego, April 26-30, 2014.

4.  Soumyadip Sahu, Ronaldo Chavez, Rituparna Ganguly, and Priya Raman (2013) Transcriptional mechanisms that mediate upregulation of thrombospondin-1 expression by leptin in vascular smooth muscle cells.  Experimental Biology, Boston, April 20-24, 2013.

5.  Priya Raman, Christy Harry, Malory Weber, Irene Krukovets, and Olga I. Stenina (2009) Cell-type specific regulation of thrombospondin-1 transcription by high glucose.  Keystone Symposium-Complications of Diabetes and Obesity, Vancouver, BC, February 24-March 1, 2009.