Yeong-Renn Chen, Ph.D.
Department of Integrative Medical Sciences
College of Medicine
Ph.D., Biochemistry, Oklahoma State University, Stillwater, Okla. - 1994
B.S., Agricultural Chemistry, National Taiwan University, Taipei, Taiwan -1986
Professor, Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, Ohio - July 2015-present
Associate Professor, Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, Ohio - January 2010-June 2015
Associate Professor, Division of Cardiovascular Medicine, Department of Internal Medicine, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio - December 2007-December 2009
Assistant Professor, Division of Cardiovascular Medicine, Department of Internal Medicine, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio - September 2002-December 2007
IRTA Fellow, NIEHS, National Institutes of Health, Research Triangle Park, N.C. - November 1997-August 2002
Research Associate, Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, Okla. - June 1994-November 1997
Graduate Research Assistant, Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, Okla. - August 1989-May 1994
Research Assistant, School of Pharmacy, National Taiwan University, Taipei, Taiwan - September 1988-July 1989
Compulsory Military Service (Army), Taiwan, Retired at the Rank of Staff Sergeant - September 1986-July 1988
Kang, P.T., Chen, C-L, and Chen, Y-R (2015) Increased mitochondrial prooxidant activity mediates up-regulation of Complex I S-glutathionylation via protein thiyl radical in the murine heart of eNOS. Free Radic Biol Med. 79:56-68. (PMCID:PMC4339473)
Chen Y-R and Zweier JL (2014) Cardiac Mitochondria and ROS Generation. Circulation Research, 114, 524-37. (PMCID: PMC4118662)
Kang PT, Chen C-L, Zen P., and Chen Y-R (2014) BCNU-induced GR2 Defect Mediates S-Glutathionylation of Complex I and Respiratory Uncoupling in Myocardium. Biochemical Pharmacology, 89, 490-502. (PMCID: PMC4035428).
Pung YF, Sam WJ, Stevanov K, Enrick M, Chen CL, Kolz C, Thakker P, Hardwick JP, Chen Y-R, Dyck JR, Yin, L, Chilian WM. (2013) Mitochondrial oxidative stress corrupts coronary collateral growth by activating adenosine monophosphate activated kinase-a signaling. Arterioscler. Thromb. Vasc. Biol. 33, 1911-9. (PMID: 23788766).
Lee, H-L, Chen, C-L, Kang, TP, Yeh, ST, Zweier, JL, Chen, Y-R (2012) Biphasic Modulation of Mitochondrial Electron Transport Chain in Myocardial Ischemia and Reperfusion. Am J. Physiol Heart, Circ Physiol. 302: H1410-H1422.
Kang TP, Zhang L, Chen C-L, Green-Church KB, Chen Y-R (2012) Protein Thiyl Radical Mediates S-Glutathionylation of Complex I. Free Radical Biology & Medicine. 53: 962-973.
Chen, C-A, Lin, C-H, Druhan LJ, Wang T-Y, Chen Y-R, Zweier JL (2011) Superoxide Induces eNOS Protein Thiyl Radical Formation: a novel mechanism regulating eNOS function and coupling. J. Biol. Chem. 33, 29098-107
Chen J, Chen C-L, Alevriadou BR, Zweier JL, Chen Y-R (2011) Excess Nitric Oxide Predisposes Mitochondrial Succinate-Cytochrome c Reductase to Produce Hydroxyl Radical. Biochim. Biophys. Acta (Bioenergetics). 1807, 491-502, PMID: 21406178.
Cai M, Li Y, Xu Y, Swartz HM, Chen C-L, Chen Y-R, and He G. (2011) Endothelial NOS Activity and Myocardial Oxygen Metabolism Define the Salvageable Ischemic Time Window for Ischemic Postconditioning. Am J Physiol Heart Circ Physiol. 300, H1069-77, PMID: 21217066.
Kang TP, Yun J, Kaumaya PT and Chen Y-R (2011) Design and Use of Peptide-based Antibodies to Suppress Mitochondrial Electron Transfer Complexes. Biopolymer: Peptide Science. 96: 207-221, PMID: 20564035.
Chen, C-A, Wang T-Y, Varadharaj S, Reyes L, Hermann C, Talukder MAH, Chen Y-R, Druhan LJ, and Zweier JL (2010) S-glutathionylation uncouples eNOS regulating its cellular and vascular function. Nature, 468: 1115-1118, PMID: 21179168
Chen W, Druhan L, Chen C-A, Hemann C, Chen Y-R, Berka V, Tsai A-L, Zweier JL (2010) Peroxynitrite-induced Destruction of the Tetrahydrobiopterin and Heme in Endothelial Nitric Oxide Synthase: Transition from Reversible to Irreversible Enzyme Inhibition. Biochemistry, 49: 3129-37
Yeh T Steve, Angelos MG, Chen Y-R (2010) Simplified Method for Concentration of Mitochondrial Membrane Protein Complexes. Electrophoresis. 31, 1934-36.
Zhang L, Chen C-L, Kang TP, Hu K, Green-Church K, Chen Y-R (2010) Peroxynitrite-Mediated Oxidative Modifications of Complex II: Relevance in the Myocardial Infarction. Biochemistry, 49, 2529-39.
Chen, J, Chen, C-L, Rawale, S, Chen, C-A, Zweier, JL, Kaumaya, PT, Chen, Y-R (2010) Peptide-based antibodies against glutathione-binding domains suppress Superoxide Production Mediated by Mitochondrial Complex I. J. Biol. Chem. 285 (5) 3168-3180.
Yeh T. Steve, Lee, H-L, Aune, SE, Chen, C-L, *Chen, Y-R, Angelos, MG (2009) Preservation of Mitochondrial Function with Cardiopulmonary Resuscitation in Prolonged Cardiac Arrest in Rats. J. Mol. Cell. Cardiology. 46, 789-97. *corresponding author
Zhang L, Xu H, Chen C-L, Green-Church KB, Freitas MA, Chen Y-R* (2008). Mass Spectrometry Profiles Superoxide-induced Formation of Mixed Intra-molecular Protein Disulfide on the FMN-binding Subunit of Mitochondrial Complex I. J. Amer. Soc. of mass Spectrom. 19 1875-86. *corresponding author
Chen C-L, Chen J., Rawale S, Varadharaj S, Kaumaya P, Zweier JL, Chen Y-R* (2008). Protein Tyrosine Nitration of Flavin Subunit is Associated with Oxidative Modification of Mitochondrial Complex II in the Post-ischemic Myocardium. J. Biol. Chem. 283 (41) 27991-28003. *corresponding author
Chen Y-R* (2008). EPR Spin-trapping and Nano LC MS/MS Techniques for DEPMPO/*OOH and Immunospin-trapping with Anti-DMPO Antibody in Mitochondrial Electron Transport System. In Advanced Protocols for Oxidant Stress, Methods of Molecular Biology. Vol 477, 75-88. *corresponding author
Chen Y-R*, Chen C-L, Zweier JL (2007). Mitochondrial Complex II in the Post-ischemic Heart: Oxidative Injury and Protective Role of S-Glutathiolation. J. Biol. Chem. 282 (45) 32640-32654. *corresponding author