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Yeong-Renn Chen Ph.D.

Associate Professor of Integrative Medical Sciences

Integrative Medical Sciences

 

Phone: (330)325-6537

Location: RGE-338

ychen1@neomed.edu

 

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Yeong-Renn Chen, Ph.D.

Associate Professor
Department of Integrative Medical Sciences
College of Medicine

Education

Ph.D., Biochemistry, Oklahoma State University, Stillwater, Okla. - 1994

B.S., Agricultural Chemistry, National Taiwan University, Taipei, Taiwan -1986

Professional Experience

Associate Professor, Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, Ohio - January 2010-present

Associate Professor, Division of Cardiovascular Medicine, Department of Internal Medicine, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio - December 2007-December 2009

Assistant Professor, Division of Cardiovascular Medicine, Department of Internal Medicine, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio - September 2002-December 2007

IRTA Fellow, NIEHS, National Institutes of Health, Research Triangle Park, N.C. - November 1997-August 2002

Research Associate, Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, Okla. - June 1994-November 1997

Graduate Research Assistant, Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, Okla. - August 1989-May 1994

Research Assistant, School of Pharmacy, National Taiwan University, Taipei, Taiwan - September 1988-July 1989

Compulsory Military Service (Army), Taiwan, Retired at the Rank of Staff Sargeant - September 1986-July 1988

Recent Publications

Dr. Chen's Publications Listed in PubMed

Chen, C-A, Lin, C-H, Druhan, LJ, Wang, T-Y, Chen, Y-R, Zweier, JL (2011) Superoxide Induces eNOS Protein Thiyl Radical Formation: a novel mechanism regulating eNOS function and coupling. J. Biol. Chem. In press. PMID: 21666221.

Chen, J., Chen, C-L, Alevriadou, B.R., Zweier, JL, Chen, Y-R (2011) Excess Nitric Oxide Predisposes Mitochondrial Succinate-Cytochrome c Reductase to Produce Hydroxyl Radical. Biochim. Biophys. Acta (Bioenergetics). 1807, 491-502, PMID: 21406178.

Cai, M., Li, Y., Xu, Y., Swartz, H.M., Chen, C-L, Chen, Y-R, and He, G. (2011) Endothelial NOS Activity and Myocardial Oxygen Metabolism Define the Salvageable Ischemic Time Window for Ischemic Postconditioning.  Am J Physiol Heart Circ Physiol.  300, H1069-77, PMID: 21217066.

Kang, T.P., Yun, J., Kaumaya, PT and Chen, Y-R (2011) Design and Use of Peptide-based Antibodies to Suppress Mitochondrial Electron Transfer Complexes. Biopolymer: Peptide Science. 96: 207-221, PMID: 20564035.

Chen, C-A, Wang T-Y, Varadharaj, S., Reyes, L, Hermann, C., Talukder, MAH, Chen, Y-R, Druhan, LJ, and Zweier, JL (2010) S-glutathionylation uncouples eNOS regulating its cellular and vascular function. Nature, 468: 1115-1118, PMID: 21179168

Chen, W., Druhan, L., Chen, C-A, Hemann, C., Chen, Y-R, Berka, V., Tsai, A-L, Zweier, J.L. (2010) Peroxynitrite-induced Destruction of the Tetrahydrobiopterin and Heme in Endothelial Nitric Oxide Synthase: Transition from Reversible to Irreversible Enzyme Inhibition. Biochemistry, 49: 3129-37

Yeh T. Steve, Angelos, MG, Chen, Y-R (2010) Simplified Method for Concentration of Mitochondrial Membrane Protein Complexes. Electrophoresis. 31, 1934-36.

Zhang, L., Chen, C-L, Kang, T.P., Hu, K, Green-Church, K, Chen, Y-R (2010) Peroxynitrite-Mediated Oxidative Modifications of Complex II: Relevance in the Myocardial Infarction. Biochemistry, 49, 2529-39.

Chen, J, Chen, C-L, Rawale, S, Chen, C-A, Zweier, JL, Kaumaya, PT, Chen, Y-R (2010) Peptide-based antibodies against glutathione-binding domains suppress Superoxide Production Mediated by Mitochondrial Complex I. J. Biol. Chem. 285 (5) 3168-3180.

Liu B, Zhu, X, Chen C-L, Hu K, Swartz HM, Chen Y-R, He G (2009) Opening the MitoKATP Channel and Decoupling of Mitochondrial Complex II and Complex III Contribute to Suppression of Myocardial Reperfusion Hyperoxygenation. Mol. and Cell. Biochem., 337, 25-38

Yeh T. Steve, Lee, H-L, Aune, SE, Chen, C-L, *Chen, Y-R, Angelos, MG (2009) Preservation of Mitochondrial Function with Cardiopulmonary Resuscitation in Prolonged Cardiac Arrest in Rats. J. Mol. Cell. Cardiology. 46, 789-97.  *corresponding author

Zuo L, Chen Y-R, Reyes, L.A., Lee, H-L, Chen C-L, Villamena FA, Zweier JL (2009) The Radical Trap 5,5-Dimethyl-1-pyrroline N-oxide Exerts Dose-Dependent Protection Against Myocardial Ischemia-Reperfusion Injury Through Preservation of Mitochondrial Electron Transport. J. Pharmacology and Experimental Therapeutics. 329, 515-523.

Liu, B, Tewari, AK, Zhang, L, Green-Church, KB, Chen, Y-R, Zweier, JL, He, G (2009) Proteomic Analysis of Protein Tyrosine Nitration after Ischemic Reperfusion Injury: Mitochondria as the Major Target.  Biochim. Biophys. Acta.- Protein and Proteomics. 389, 143-49.

Zou L, Chen Y-R, Chen C-L, Villamena FA, Zweier, JL (2008). The Radical Trap 5,5-Dimethyl-1-pyrroline N-oxide Exerts Dose-Dependent Protection Against Myocardial Ischemia-Reperfusion Injury Through Preservation of Mitochondrial Electron Transport.  J. Pharmacology and Experimental Therapeutics. Revised and resubmitted.

Liu B, Tewari AK, Zhang L, Green-Church KB, Chen Y-R, Zweier JL, He G (2008).  Proteomic Analysis of Protein Tyrosine Nitration after Ischemic Rerperfusion Injury:  Mitochondria as the Major Target.  Biochim. Biophys. Acta.-Protein and Proteomics.  In press.

Zhang L, Xu H, Chen C-L, Green-Church KB, Freitas MA, Chen Y-R* (2008).  Mass Spectrometry Profiles Superoxide-induced Formation of Mixed Intra-molecular Protein Disulfide on the FMN-binding Subunit of Mitochondrial Complex I. J. Amer. Soc. of mass Spectrom. 19 1875-86. *corresponding author

Chen C-L, Chen J., Rawale S, Varadharaj S, Kaumaya P, Zweier JL, Chen Y-R* (2008).  Protein Tyrosine Nitration of Flavin Subunit is Associated with Oxidative Modification of Mitochondrial Complex II in the Post-ischemic Myocardium. J. Biol. Chem. 283 (41) 27991-28003. *corresponding author

Chen C-A, Druhan LJ, Varadharaj S, Chen Y-R, Zweier JL (2008).  Phosphorylation of the Endothelial Nitric Oxide Synthase (eNOS) Increases Superoxide Generation from the Enzyme.  J. Biol. Chem. 283 (41) 27038-47.

Chen Y-R* (2008). EPR Spin-trapping and Nano LC MS/MS Techniques for DEPMPO/*OOH and Immunospin-trapping with Anti-DMPO Antibody in Mitochondrial Electron Transport System.  In Advanced Protocols for Oxidant Stress, Methods of Molecular Biology.  Vol 477, 75-88.  *corresponding author

Chen Y-R*, Chen C-L, Zweier JL (2007).  Mitochondrial Complex II in the Post-ischemic Heart: Oxidative Injury and Protective Role of S-Glutathiolation.  J. Biol. Chem. 282 (45) 32640-32654. *corresponding author

Zhu X, Liu B, Zhou S, Chen Y-R, Deng Y, Zweier JL, He G (2007).  Ischemic Preconditioning Decreases Formation of Reactive Oxygen/Nitrogen Species and Regulates In Vivo Tissue Oxygenation and Oxygen Consumption in Postischemic Hearts.  Am J Physiol Heart Circ Physiol. 293 (3): H1442-50