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Yoon-Kwang Lee Ph.D.

Assistant Professor of Integrative Medical Sciences

Integrative Medical Sciences


Phone: (330)325-6415

Location: F-344


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Yoonkwang Lee, Ph.D.

Assistant Professor
Department of Integrative Medical Sciences
College of Medicine


Ph.D., Molecular Biology, Rutgers University, New Jersey - 1995

M.S., Biotechnology, Yonsei University, Korea - 1987

B.S., Food Engineering, Yonsei University, Korea - 1985

Professional Experience

Assistant Professor of Molecular and Cellular Biology, Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, Ohio - 2008-present

Assistant Professor, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas - 2005-2008

Research Assistant Professor, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas - 2001-2005

Instructor, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas - 2000-2001

Postdoctoral Associate, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas - 1997-2000

Research Fellow, Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts - 1995-1997

Research Interests

Role of orphan nuclear receptor SHP in diet induced diabetes and obesity.

Recent Publications

Park YJ, Kim SC, Kim J, Sayeepriyadarshini A, Lee JM, Tseng HT, Yechoor, V, Park J, Choi JS, Jang HC, Lee KU, Novak CM, Moore DD, and Lee YK. 2011. Dissociation of diabetes from obesity in mice lacking orphan nuclear receptor small heterodimer partner. J Lipid Res. In Press

Lee JM, Lee YK, Mamrosh JL, Busby SA, Griffin, PR, Pathak MC, Ortlund EA, and Moore DD. 2011. A nuclear receptor-dependent phosphatidylcholine pathway with antidiabetic effects. Nature. 474(7352):506-510

Li T, Ma H, Park YJ, Lee YK, Strom S, Moore DD, and Chiang JY. 2009. Forkhead box transcription factor O1 inhibits cholesterol 7alpha-hydroxylase in human hepatocytes and in high fat diet-fed mice. Biochim Biophys Acta. 1791(10):991-996

Lee YK, Liu DJ, Lu J, Chen KY, and Liu AY. 2009. Aberrant Regulation and Modification of Heat Shock Factor 1 in Senescent Human Diploid Fibroblasts. J Cell Biochem. 106(2):267-278

Lee YK and Moore DD. 2008. Liver Receptor Homolog-1, An Emerging Metabolic Modulator. Front Biosci. 13:5950-5958.

Park YJ, Qatanani M, Chua S, LaRey J, Moore DD and Lee YK. 2008. Loss of Orphan Receptor Small Heterodimer Partner Sensitizes Mice To Liver Injury From Obstructive Cholestasis. Hepatology 47(5):1578-1586.

Lee YK, Choi YH, Chua S, Park YJ, and Moore DD. 2006. Phosphorylation of the hinge domain of the nuclear hormone receptor LRH-1 stimulates transactivation. J Biol Chem. 281(12):7850-7855

Ortlund EA, Lee Y, Solomon IH, Hager JM, Safi R, Choi Y, Guan Z, Tripathy A, Raetz CR, McDonnell DP, Moore DD, Redinbo MR. 2005. Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP. Nat Struct Mol Biol. 12(4):357-363

Lee YK and Moore DD. 2003. The orphan receptor SHP and the three-hybrid interference assay. Methods Enzymol. 364:152-159

Wang L, Han Y, Kim CS, Lee YK, and Moore DD. 2003. Resistance of SHP-null mice to bile acid-induced liver damage. J Biol Chem. 278(45):44475-44481

Wang L, Lee YK, Bundman D, Han Y, Thevananther S, Kim CS, Chua SS, Wei P, Heyman RA, Karin M, Moore DD. 2002. Redundant pathways for negative feedback regulation of bile acid production. Dev Cell. 2(6):721-731

Lee YK and Moore DD. 2002. Dual Mechanisms for repression of the monomeric orphan receptor Liver Receptor Homologous Protein-1 by the orphan Small Heterodimer Partner. J Biol Chem. 277(4):2463-2467

Sanyal S, Kim JY, Kim HJ, Takeda J, Lee YK, Moore DD, and Choi HS. 2002. Differential regulation of the orphan nuclear receptor SHP gene promoter by orphan nuclear receptor ERR isoforms. J Biol Chem. 277(3):1739-1748

Nishigori H, Tomura H, Tonooka N, Kanamori M, Yamada S, Sho K, Inoue I, Kikuchi N, Onigata K, Kojima I, Kohana T, Yamagata K, Yang Q, Matsuzawa Y, Miki T, Seino S, Kim MY, Choi HS, Lee YK, Moore DD, and Takeda J. 2001. Mutations in the small heterodimer partner gene are associated with mild obesity in Japanese subjects. Proc Natl Acad Sci. 98(2):575-580

Lee YK, Helen D, Dowhan DH, Hadzopoulou-Cladaras M, and Moore DD. 2000. The orphan nuclear receptor SHP inhibits HNF-4 and RXR transactivation: Two mechanisms for repression. Mol Cell Biol. 20(1):187-195.