Yoonkwang Lee, Ph.D.
Department of Integrative Medical Sciences
College of Medicine
Ph.D., Molecular Biology, Rutgers University, New Jersey - 1995
M.S., Biotechnology, Yonsei University, Korea - 1987
B.S., Food Engineering, Yonsei University, Korea - 1985
Assistant Professor of Molecular and Cellular Biology, Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, Ohio - 2008-present
Assistant Professor, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas - 2005-2008
Research Assistant Professor, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas - 2001-2005
Instructor, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas - 2000-2001
Postdoctoral Associate, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas - 1997-2000
Research Fellow, Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts - 1995-1997
Ongoing Research Support
R01 DK093774 12/01/12 – 11/30/2017
Title: Hepatic Lipid Mobilization by Nuclear Hormone Receptors
The goals of this project are to explore physiological roles of a proposed novel transcriptional cascade in the development of diet-induced hepatic steatosis using mouse models with fatty liver diseases.
R01 DK068804 David D. Moore, PI 4/01/2005 -- 3/31/2009
Title: Functions of the nuclear receptor SHP
The goals of this proposal are to characterize the functions of the orphan nuclear hormone receptor SHP in metabolic regulation.
OBR Research Incentive Award 2/01/2009 - 1/31/2010
NEOUCOM/Office of Research and Sponsored Programs
Title: Physiological Functions of the Orphan Nuclear Receptor SHP in the Development of Diabetes
The goal of this proposal is to examine gene expression in the liver and islets isolated from SHP-/- and wild type mice to delineate the potential roles of SHP in the development of diabetes by a western diet.
Submitted Research Support but not funded
1S10 OD018179-01 4/01/2014-3/31/2015
Title: Shared Instrumentation Grant Program
The proposal is to obtain EchoMRI 4-in-1 to analyze body fat mass and lean tissue mass in non-invasive way. This will allow us to interpret correctly the energy expenditure data obtained from longitudinal metabolic studies using CLAMS (Comprehensive Lab Animal Monitoring System).
Role: Director and major user
Role of orphan nuclear receptor SHP in diet induced diabetes and obesity.
Pan X, Lee YK, and Jeong H. 2015. Farnesoid X Receptor Agonist Represses Cytochrome P450 2D6 Expression by Upregulating Small Heterodimer Partner. Drung Metab Dispos 43(7):1002-1007.
Tseng HT, Park YJ, Lee YK, and Moore DD. 2015 The orphan nuclear receptor small heterodimer partner is required for thiazolidinedione effects in leptin-deficient mice. J Biomed Sci 22 (1): 30.
Kim SC, Kim C, Axe D, Cook A, Lee M, Li T, Smallwood N, Chiang JYL, Hardwick JP, Moore DD, Lee YK. 2013. All-trans-retinoic acid ameliorates hepatic steatosis in mice via a novel transcriptional cascade. Hepatology 59(5):1750-1760.
Park YJ, Kim SC, Kim J, Sayeepriyadarshini A, Lee JM, Tseng HT, Yechoor, V, Park J, Choi JS, Jang HC, Lee KU, Novak CM, Moore DD, and Lee YK. 2011. Dissociation of diabetes from obesity in mice lacking orphan nuclear receptor small heterodimer partner. J Lipid Res. In Press
Lee JM, Lee YK, Mamrosh JL, Busby SA, Griffin, PR, Pathak MC, Ortlund EA, and Moore DD. 2011. A nuclear receptor-dependent phosphatidylcholine pathway with antidiabetic effects. Nature. 474(7352):506-510
Li T, Ma H, Park YJ, Lee YK, Strom S, Moore DD, and Chiang JY. 2009. Forkhead box transcription factor O1 inhibits cholesterol 7alpha-hydroxylase in human hepatocytes and in high fat diet-fed mice. Biochim Biophys Acta. 1791(10):991-996
Lee YK, Liu DJ, Lu J, Chen KY, and Liu AY. 2009. Aberrant Regulation and Modification of Heat Shock Factor 1 in Senescent Human Diploid Fibroblasts. J Cell Biochem. 106(2):267-278
Lee YK and Moore DD. 2008. Liver Receptor Homolog-1, An Emerging Metabolic Modulator. Front Biosci. 13:5950-5958.
Park YJ, Qatanani M, Chua S, LaRey J, Moore DD and Lee YK. 2008. Loss of Orphan Receptor Small Heterodimer Partner Sensitizes Mice To Liver Injury From Obstructive Cholestasis. Hepatology 47(5):1578-1586.
Lee YK, Choi YH, Chua S, Park YJ, and Moore DD. 2006. Phosphorylation of the hinge domain of the nuclear hormone receptor LRH-1 stimulates transactivation. J Biol Chem. 281(12):7850-7855
Ortlund EA, Lee Y, Solomon IH, Hager JM, Safi R, Choi Y, Guan Z, Tripathy A, Raetz CR, McDonnell DP, Moore DD, Redinbo MR. 2005. Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP. Nat Struct Mol Biol. 12(4):357-363
Lee YK and Moore DD. 2003. The orphan receptor SHP and the three-hybrid interference assay. Methods Enzymol. 364:152-159
Wang L, Han Y, Kim CS, Lee YK, and Moore DD. 2003. Resistance of SHP-null mice to bile acid-induced liver damage. J Biol Chem. 278(45):44475-44481
Wang L, Lee YK, Bundman D, Han Y, Thevananther S, Kim CS, Chua SS, Wei P, Heyman RA, Karin M, Moore DD. 2002. Redundant pathways for negative feedback regulation of bile acid production. Dev Cell. 2(6):721-731
Lee YK and Moore DD. 2002. Dual Mechanisms for repression of the monomeric orphan receptor Liver Receptor Homologous Protein-1 by the orphan Small Heterodimer Partner. J Biol Chem. 277(4):2463-2467
Sanyal S, Kim JY, Kim HJ, Takeda J, Lee YK, Moore DD, and Choi HS. 2002. Differential regulation of the orphan nuclear receptor SHP gene promoter by orphan nuclear receptor ERR isoforms. J Biol Chem. 277(3):1739-1748
Nishigori H, Tomura H, Tonooka N, Kanamori M, Yamada S, Sho K, Inoue I, Kikuchi N, Onigata K, Kojima I, Kohana T, Yamagata K, Yang Q, Matsuzawa Y, Miki T, Seino S, Kim MY, Choi HS, Lee YK, Moore DD, and Takeda J. 2001. Mutations in the small heterodimer partner gene are associated with mild obesity in Japanese subjects. Proc Natl Acad Sci. 98(2):575-580
Lee YK, Helen D, Dowhan DH, Hadzopoulou-Cladaras M, and Moore DD. 2000. The orphan nuclear receptor SHP inhibits HNF-4 and RXR transactivation: Two mechanisms for repression. Mol Cell Biol. 20(1):187-195.