Integrative Medical Sciences
William M. Chilian, Ph.D.
Chair of Integrative Medical Sciences and Professor of Physiology
Department of Integrative Medical Sciences
College of Medicine
St. Olaf College, Northfield, Minnesota; B.A., Honors in Biology, cum laude 05/74
Texas Tech University, Lubbock, Texas; M.S., 05/76
University of Missouri, Columbia, Missouri; Ph.D., 12/80
Professor and Chair, Department of Integrative Medical Sciences, Northeast Ohio Medical University - 06/01/07-present
Superchair of Basic Cardiovascular Research, Department of Physiology, LSU Health Sciences Center in New Orleans, Kenneth A. Ardoin/Pfizer - 06/14/02-05/31/07
Professor, Department of Physiology, LSU Health Sciences Center in New Orleans - 06/01/02-05/31/07; Chair - 06/01/02-05/15/06
Professor, Department of Physiology, Medical College of Wisconsin - 01/01/96-05/31/02
Associate Director, Cardiovascular Center - 04/01/00-05/31/02
Professor, Department of Medical Physiology, College of Medicine, Texas A&M University Health Science Center - 09/01/94-12/31/95
Visiting Scientist, Department of Experimental Cardiology, Max-Planck-Institute for Clinical Physiology, Bad Nauheim, Germany - 09/01/93-08/31/94
Associate Professor, Department of Medical Physiology, College of Medicine, Texas A&M University Health Science Center - 09/01/91-08/31/95
Assistant Professor, Department of Medical Physiology, College of Medicine, Texas A&M University - 01/01/87-08/31/91
Assistant Research Scientist, Department of Internal Medicine and the Cardiovascular Center, University of Iowa - 07/01/82-12/31/86
Adjunct Associate, Department of Physiology and Biophysics, University of Iowa - 07/01/83-06/30/84
Research Fellow, Department of Internal Medicine and The Cardiovascular Center, University of Iowa, Iowa City, Iowa - 09/01/80-06/30/82
Regulatory Mechanisms in the Coronary Microcirculation
Coronary Angiogenesis and Arteriogenesis
Non-linear Behavior of Biological Systems
Mechanosensitive Gene Expression and Signal Transduction
Redox Regulation of Ion Channel Function
Pung YF, Chilian WM. Corruption of coronary collateral growth in metabolic syndrome: Role of oxidative stress. World J Cardiol. 2010 Dec 26;2(12):421-7.
Carrao AC, Chilian WM, Yun J, Kolz C, Rocic P, Lehmann K, van den Wijngaard JP, van Horssen P, Spaan JA, Ohanyan V, Pung YF, Buschmann I. Stimulation of coronary collateral growth by granulocyte stimulating factor: role of reactive oxygen species. Arterioscler Thromb Vasc Biol. 2009 Nov;29(11):1817-22
Yun J, Rocic P, Pung YF, Belmadani S, Carrao AC, Ohanyan V, Chilian WM. Redox-dependent mechanisms in coronary collateral growth: the "redox window" hypothesis. Antioxid Redox Signal. 2009 Aug;11(8):1961-74
Belmadani S, Matrougui K, Kolz C, Pung YF, Palen D, Prockop DJ, Chilian WM. Amplification of coronary arteriogenic capacity of multipotent stromal cells by epidermal growth factor. Arterioscler Thromb Vasc Biol. 2009 Jun;29(6):802-8
Trzeciakowski J, Chilian WM. Chaotic behavior of the coronary circulation. Med Biol Eng Comput. 2008;46:433-442
Kaye AD, Hoover JM, Kaye AJ, Ibrahim IN, Fox C, Bajwa A, Anwar M, Fields AM, Baluch A, Huffman S, Chilian W. Morphine, opioids, and the feline pulmonary vascular bed. Acta Anaesthesiol Scand. 2008;52:931-937
Chilian WM, Pung YF. Vascular endothelial growth factor and the collateral circulation: the story continues. Circ Res. 2008;103:905-906
Rogers PA, Chilian WM, Bratz IN, Bryan RM, Jr., and Dick GM. H2O2 activates redox- and 4-aminopyridine-sensitive Kv channels in coronary vascular smooth muscle. Am J Physiol Heart Circ Physiol 292: H1404-1411, 2007.
Gao X, Belmadani S, Picchi A, Xu X, Potter BJ, Tewari-Singh N, Capobianco S, Chilian WM, and Zhang C. Tumor necrosis factor-alpha induces endothelial dysfunction in Lepr(db) mice. Circulation 115: 245-254, 2007.
Focardi M, Dick GM, Picchi A, Zhang C, and Chilian WM. Restoration of coronary endothelial function in obese Zucker rats by a low-carbohydrate diet. Am J Physiol Heart Circ Physiol 292: H2093-2099, 2007.
Rocic P, Kolz C, Reed R, Potter B, and Chilian WM. Optimal reactive oxygen species concentration and p38 MAP kinase are required for coronary collateral growth. Am J Physiol Heart Circ Physiol 292: H2729-2736, 2007.
Hattan N, Chilian WM, Park F, and Rocic P. Restoration of coronary collateral growth in the Zucker obese rat: impact of VEGF and ecSOD. Basic Res Cardiol 102: 217-223, 2007.
Gao X, Xu X, Belmadani S, Park Y, Tang Z, Feldman AM, Chilian WM, and Zhang C. TNF-alpha contributes to endothelial dysfunction by upregulating arginase in ischemia/reperfusion injury. Arterioscler Thromb Vasc Biol 27: 1269-1275, 2007.
Saitoh S, Kiyooka T, Rogers PA, Dick GM, Rocic P, Swafford A, Viswanathan C, Park Y, Zhang C, and Chilian WM. Redox-Dependent Coronary Metabolic Dilation. Am J Physiol Heart Circ Physiol 2007.
Zhang C, Xu X, Potter BJ, Wang W, Kuo L, Michael L, Bagby GJ, and Chilian WM. TNF-alpha contributes to endothelial dysfunction in ischemia/reperfusion injury. Arterioscler Thromb Vasc Biol 26: 475-480, 2006.
Sato M, Cismowski MJ, Toyota E, Smrcka AV, Lucchesi PA, Chilian WM, and Lanier SM. Identification of a receptor-independent activator of G protein signaling (AGS8) in ischemic heart and its interaction with Gbetagamma. Proc Natl Acad Sci U S A 103: 797-802, 2006.
Picchi A, Gao X, Belmadani S, Potter BJ, Focardi M, Chilian WM, and Zhang C. Tumor necrosis factor-alpha induces endothelial dysfunction in the prediabetic metabolic syndrome. Circ Res 99: 69-77, 2006.
Rogers PA, Dick GM, Knudson JD, Focardi M, Bratz IN, Swafford AN, Jr., Saitoh S, Tune JD, and Chilian WM. H2O2-induced redox-sensitive coronary vasodilation is mediated by 4-aminopyridine-sensitive K+ channels. Am J Physiol Heart Circ Physiol 291: H2473-2482, 2006.
Rogers PA, Kiyooka T, and Chilian WM. Is there a need for another model on the pulsatile nature of coronary blood flow? Am J Physiol Heart Circ Physiol 291: H1034-1035, 2006.
Saitoh S, Zhang C, Tune JD, Potter B, Kiyooka T, Rogers PA, Knudson JD, Dick GM, Swafford A, and Chilian WM. Hydrogen peroxide: a feed-forward dilator that couples myocardial metabolism to coronary blood flow. Arterioscler Thromb Vasc Biol 26: 2614-2621, 2006.