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William Chilian Ph.D.

Professor of Physiology

Graduate Faculty Advsg Status College of Graduate Studies

Integrative Medical Sciences

 

Phone: (330)325-6426

Location: RGE-335

wchilian@neomed.edu

 

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William M. Chilian, Ph.D.

Chair of Integrative Medical Sciences and Professor of Physiology
Department of Integrative Medical Sciences
College of Medicine

Education

University of Missouri, Columbia, Missouri; Ph.D., 12/80

Texas Tech University, Lubbock, Texas; M.S., 05/76

St. Olaf College, Northfield, Minnesota; B.A., Honors in Biology, cum laude 05/74

Professional Experience

Professor and Chair, Department of Integrative Medical Sciences, Northeast Ohio Medical University - 06/01/07-present

Superchair of Basic Cardiovascular Research, Department of Physiology, LSU Health Sciences Center in New Orleans, Kenneth A. Ardoin/Pfizer - 06/14/02-05/31/07

Professor, Department of Physiology, LSU Health Sciences Center in New Orleans -  06/01/02-05/31/07; Chair - 06/01/02-05/15/06

Professor, Department of Physiology, Medical College of Wisconsin - 01/01/96-05/31/02

Associate Director, Cardiovascular Center - 04/01/00-05/31/02

Professor, Department of Medical Physiology, College of Medicine, Texas A&M University Health Science Center  - 09/01/94-12/31/95

Visiting Scientist, Department of Experimental Cardiology, Max-Planck-Institute for Clinical Physiology, Bad Nauheim, Germany - 09/01/93-08/31/94

Associate Professor, Department of Medical Physiology, College of Medicine, Texas A&M University Health Science Center - 09/01/91-08/31/95

Assistant Professor, Department of Medical Physiology, College of Medicine, Texas A&M University - 01/01/87-08/31/91

Assistant Research Scientist, Department of Internal Medicine and the Cardiovascular Center, University of Iowa - 07/01/82-12/31/86

Adjunct Associate, Department of Physiology and Biophysics, University of Iowa - 07/01/83-06/30/84

Research Fellow, Department of Internal Medicine and The Cardiovascular Center, University of Iowa, Iowa City, Iowa - 09/01/80-06/30/82

Research Interests

Regulatory Mechanisms in the Coronary Microcirculation

Coronary Angiogenesis and Arteriogenesis

Non-linear Behavior of Biological Systems

Mechanosensitive Gene Expression and Signal Transduction

Redox Regulation of Ion Channel Function

Personal Statement

My interest in the vascular biology has been developing for many years along the lines of acute and chronic adaptations of the coronary circulation to physiological and pathophysiological stresses.  With regard to chronic adaptations of the coronary circulation, my laboratory was the first to show that ischemia, rather than shear stress, initiates coronary collateral growth.  Shear stress is not precluded from this process; rather this mechanism plays a role in the expansion of the vessel after the ischemic stimulus wanes.  More recently my laboratory has studied the role the mitochondrial oxidative stress in coronary collateral development, and we have found that such stress blunts the adaptive growth of coronary collaterals.  Moreover, rectification of oxidative stress will restore collateral growth in a preclinical model with a poor growth phenotype.  With regard to acute adaptations of the coronary circulation to physiological and pathophysiological stresses, I am proud of the accomplishments of my laboratory:  we were the first to document myogenic and flow-dependent control of coronary tone; the distribution of microvascular resistance in the beating heart, the effects of  preconditioning extended to the vascular endothelium, the mechanism of alpha-adrenergic coronary constriction involves release of a cardiac myocyte derived vasoconstrictor, coronary metabolic dilation is a feed-forward process involving mitochondrial production of H2O2, metabolic dilation is mediated by redox reactions, and Kv1.5 channels play a critical role in metabolic dilation in the heart.  

Other Experience and Professional Memberships (since 2005)

 

2004-2006       Chair, Programming Committee, Council on Basic Cardiovascular Sciences, American Heart Association

2004-present   Consulting Editor, American Journal of Physiology: Heart and Circulatory Physiology

2005-present   Editorial Board, Arteriosclerosis, Thrombosis and Vascular Biology

2007-2011       Member, NIH Myocardial Ischemia and Metabolism Study Section (Chair, 2008-2011)

2008-2009       Vice-Chair, Programming Committee, Council on Arteriosclerosis, Thrombosis and Vascular Biology, American Heart
                           Association

2009-2012       Associate Editor, Circulation Research

MEMBERSHIP IN SCHOLARLY SOCIETIES:
 

1.  American Physiological Society, 1978-present
2.  Microcirculatory Society, 1984-present
3.  American Heart Association, Fellow of the Council on Circulation, 1986-1999; Fellow on the  Council for Basic Cardiovascular Sciences;             Fellow of the American Heart Association,1999-present
4.  American Physiological Society, Fellow of the Cardiovascular Section, 1989-present

RESEARCH AND OTHER SCHOLARLY ACTIVITIES:

 
Areas of Research:

  1. Regulatory Mechanisms in the Coronary Microcirculation
  2. Coronary Angiogenesis and Arteriogenesis
  3. Regenerative Approaches to Stimulate Coronary Collateral Growth
  4. Coronary Microvascular Disease

Honors


2001                Robert M. Berne Distinguished Lecturer

2002                Kenneth Ardoin Superchair in Basic Cardiovascular Research

2003                Konard Witzig Lecturer, Cardiac Systems Dynamics Society, Sendai Japan

2004                Spinoza Lecturer, University of Amsterdam

2013                Landis Award, Microcirculatory Society

2014                Wiggers Award, American Physiological Society

Research Support

Active:

R01 HL83366                P.I.  William M. Chilian, Ph.D.                Period:  07/01/09-06/30/15         

Title: Reactive Oxygen Species in Coronary Collateral Growth

Role: PI

Current Year Budget: $311,090

The goal of this proposal is to study the effects of oxidative stress and redox signaling in certain cells in the vasculature on coronary collateral growth and whether resolution of oxidative stress in specific cells rescues impaired collateral growth in an animal model of the metabolic syndrome.

R01 HL115114             P.I.   William M. Chilian, Ph.D.              Period:  07/01/2013-06/30/2017

Title: Mechanisms of Coronary Vasomotor Control

Role: PI

First Year Budget: $250,000

This proposal determines the ion channels that link flow to metabolism in the heart, whether altered expression of these channels induces diabetic cardiomyopathy, and if re-expression of these channels will rescue the condition.

Recent Publications

Dr. Chilian's publications listed in PubMed

Song H, Yin L, Chilian, WM, Zhang Newby BM. Dewetting based fabrication of fibrous micro-scaffolds as potential injectable cell carriers. Mater Sci Eng C Mater Biol Appl. 2015; 48:663-672

Adapala, RK, Thoppil RJ, Ghosh K, Cappelli HC, Dudley, AC, Paruchuri S, Keshamouni V, Klagsbrun M, Meszaros JG,  Chilian WM,  Ingber DE, Thodeti CK. Activation of mechanosensitive ion channel TRPV4 normalizes tumor vasculature and improves cancer therapy. Oncogene.  2015; DOI: 10.1038/onc.2015.83

Logan SJ, Yin L, Geldenhuys W, Enrick MK, Stevanov KM, Carroll RT, Ohanyan, VA, Chilian WM.  Novel Thiazolidinedione MitoNEET Ligand-1 Acutely Improves Cardiac Stem Cell Survival Under Oxidative Stress.  Basic Res Cardiol. 2015; 110: 19-26

DiVincenzo L, Reber M, Perera V, Chilian WM.  Connecting the dots—Establishing causality between chronic stress, depression, and cardiovascular disease.  J Appl Physiol. 2014; 117:957-958

Adapala RK, Thoppil RJ, Luther DJ, Paruchuri S, Meszaros JG, Chilian WM, Thodeti CK. Trpv4 channels mediate cardiac fibroblast differentiation by integrating mechanical and soluble signals. J Mol Cell Cardiol. 2013;54:45-52

Guarini G, Capozza PG, Huqi A, Morrone D, Chilian WM, Marzilli M. Microvascular function/dysfunction downstream a coronary stenosis. Curr Pharm Des. 2013;19:2366-2374

Pung YF, Sam WJ, Stevanov K, Enrick M, Chen CL, Kolz C, Thakker P, Hardwick JP, Chen YR, Dyck JR, Yin L, Chilian WM. Mitochondrial oxidative stress corrupts coronary collateral growth by activating adenosine monophosphate activated kinase-alpha signaling. Arterioscler Thromb Vasc Biol. 2013;33:1911-1919

Fedele F, Mancone M, Chilian WM, Severino P, Canali E, Logan S, De Marchis ML, Volterrani M, Palmirotta R, Guadagni F. Role of genetic polymorphisms of ion channels in the pathophysiology of coronary microvascular dysfunction and ischemic heart disease. Basic Res Cardiol. 2013;108:387

Petrak D, Atefi E, Yin L, Chilian WM, Tavana H. Automated, spatio-temporally controlled cell microprinting with polymeric aqueous biphasic system. Biotechnology and bioengineering. 2013

Yin L, Ohanyan V, Pung YF, Delucia A, Bailey E, Enrick M, Stevanov K, Kolz CL, Guarini G, Chilian WM. Induction of vascular progenitor cells from endothelial cells stimulates coronary collateral growth. Circ Res. 2012;110:241-252. 

Pung YF, Rocic P, Murphy MP, Smith RA, Hafemeister J, Ohanyan V, Guarini G, Yin L, Chilian WM. Resolution of mitochondrial oxidative stress rescues coronary collateral growth in zucker obese fatty rats. Arterioscler Thromb Vasc Biol. 2012;32:325-334

Luther DJ, Thodeti CK, Shamhart PE, Adapala RK, Hodnichak C, Weihrauch D, Bonaldo P, Chilian WM, Meszaros JG. Absence of type vi collagen paradoxically improves cardiac function, structure, and remodeling after myocardial infarction. Circ Res. 2012;110:851-856

Pung YF, Chilian WM.  Corruption of coronary collateral growth in metabolic syndrome: Role of oxidative stress.  World J Cardiol. 2010 Dec 26;2(12):421-7.