Integrative Medical Sciences
Mark A. Simmons, Ph.D.
Professor of Pharmacology
Department of Integrative Medical Sciences
College of Medicine
Ph.D., Pharmacology, Concentration in Neuroscience, Loyola University of Chicago, Chicago, Ill. - 1983
B.S., Psychology, Minor in Mathematics and Computer Science, University of South Carolina, Columbia, S.C. - 1976
Professor of Pharmacology, Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, Ohio - 2000-Present
Professor, Department of Pharmaceutical Sciences, Northeast Ohio Medical University, Rootstown, Ohio - 2010-Present
Professor, Pharmacology Graduate Program, School of Biomedical Sciences, Kent State University, Kent, Ohio - 2000-Present
Visiting Scientist, Department of Neuroscience Biology, AstraZeneca Pharmaceuticals, Wilmington, Delaware - 2006-2007
Academic Visitor, Department of Pharmacology, University College - London, London, England - June-July 2000
Research Scientist, Department of Veterans Affairs Medical Center, Huntington, West Virginia - 1998-2000
Professor, Department of Pharmacology, Marshall University School of Medicine, Huntington, West Virginia - 1995-2000, Associate Professor - 1991-1995, Assistant Professor, 1987-1991
Senior Fellow in Neurobiology, Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, Missouri - 1993-1994
Associate in Anatomy and Cell Biology, Department of Anatomy and Cell Biology, Emory University School of Medicine, Atlanta, Georgia - 1985-1987
Academic Computing Specialist, Academic Computing Services, Loyola University Medical Center, Maywood, Illinois - 1982-1983, Programming Advisor, 1979-1982
Research Assistant, Behavioral Pharmacology Laboratory, Department of Psychology, University of South Carolina, Columbia, South Carolina - 1976-1979
- Behavioral, cellular and molecular neuropharmacology.
- Cellular and molecular mechanisms of neurotransmitter action.
- Coupling of membrane receptors to ion channels in nerve cells and cardiac muscle.
Geldenhuys, W.J., Kuzenko, S.R. and Simmons, M.A. Virtual screening to identify novel antagonists for the G protein-coupled NK3 receptor. Journal of Medicinal Chemistry, 53:8080-8088, 2010.
Simmons, M. A., Werkheiser, J.L. and Hudzik, T.J. Acute nicotine and phencyclidine increase locomotor activity of the guinea pig with attenuated potencies relative to their effects on rat or mouse. Pharmacology, Biochemistry and Behavior, 94:410-415, 2010.
Simmons, M. A., Sobotka-Briner, C.D., and Medd, A. Localization and function of NK3 receptors of layer V pyramidal neurons of the guinea pig medial prefrontal cortex. Neuroscience, 156:987-994, 2008.
Perrine, S. A., Beard, D. J., Young, J. and Simmons, M. A. The role of the N-terminal and mid-region residues of substance P in regulating functional selectivity at the NK1 receptor. European Journal of Pharmacology, 592:1-6, 2008.
Beard, D.J., Perrine, S.A., Phillips, E., Hoque, S., Conerly, S., Tichenor, C., Simmons, M.A. Young, J.K. Conformational comparisons of a series of tachykinin peptide analogs. Journal of Medicinal Chemistry 2007, 50:6501-6506.
Simmons, M.A. Functional selectivity of NK1 receptor signaling: peptide agonists can preferentially produce receptor activation or desensitization. Journal of Pharmacology & Experimental Therapeutics 2006 319:9079-13.
Simmons, M.A. Functional selectivity, ligand-directed trafficking, conformation specific agonism: what's in a name? Molecular Interventions, 5: 150-154, 2005.
Bennett, V.J., Perrine, S.A., and Simmons, M.A. Neurokinin-1 receptor resensitization results from a change in G protein coupling and not from receptor recycling. Journal of Pharmacology and Experimental Therapeutics, 313: 1347-1354, 2005.
Perrine, S.A. and Simmons, M.A. Tachykinin peptide-induced activation and desensitization of neurokinin 1 receptors. Peptides, 24:469-475, 2003.
Bennett, V.J., Perrine, S.A. and Simmons, M.A. A novel mechanism of neurokinin-1 receptor resensitization. Journal of Pharmacology and Experimental Therapeutics, 303:1155-1162, 2002.
Bennett, V.J. and Simmons, M.A. Analysis of fluorescently-labeled substance P analogs: binding, imaging and receptor activation. BMC Chemical Biology 1:1 (12 pp.). 2001.
Perrine, S. A., Whitehead, T.L., Hicks, R.P., Szarek, J. L., Krause, J. E. and Simmons, M. A. Solution structure in SDS micelles and functional activity at the bullfrog substance P receptor of ranatachykinin peptides. Journal of Medicinal Chemistry, 43:1741-1753, 2000.
Simmons, M. A. Pharmacology: An Illustrated Review, 400 pp., Thieme Medical Publishers Inc., New York, NY, 2011. ISBN 978-1-60406-205-2.
Simmons, M. A. Pharmacology: Comprehensive Review and 2000 Multiple-Choice Questions & Answers. (2nd Edition) 358 pp., Biotest Publishing Co. Inc., Ventura CA, 2002. ISBN 1-893720-11X.
Review Articles and Book Chapters
Simmons, M. A. Let’s go rafting: ligand functional selectivity may depend on membrane structure. Molecular Interventions, 6:281-283, 2008.
Simmons, M. A. Functional selectivity, ligand-directed trafficking, conformation specific agonism: what’s in a name? Molecular Interventions, 5:154-157, 2005.
Hartzell, H. C., Simmons, M. A. and Fischmeister, R. Regulation of the trans-sarcolemmal calcium current in isolated cardiac myocytes by acetylcholine and cyclic GMP. International Symposium on Muscarinic Cholinergic Mechanisms, S. Cohen & M. Sokolovsky, Eds., Freund Publishing House, Ltd., London, pp. 149-158, 1987.
Simmons, M. A. The complexity and diversity of synaptic transmission in the prevertebral sympathetic ganglia. Progress in Neurobiology, 24:43-93, 1985.