Tariq M. Haqqi, Ph.D.
Professor of Anatomy and Neurobiology
College of Medicine
1972 Aligarh Muslim University, India
B.Sc.(Hons.) in Zoology
1974 Aligarh Muslim University, India
M.Sc. in Zoology
1975 Aligarh Muslim University, India
M.Phil. in Zoology
1979 Aligarh Muslim University, India
Ph.D. in Zoology
1998 University of Oxford, England
Certificate in Bioinformatics
2012- Present Northeast Ohio Medical University, Rootstown, Ohio
Department of Anatomy and Neurobiology, Professor (Tenure in process)
2009 - 2012 MetroHealth Medical Center/ Case Western Reserve University School of Medicine, Cleveland, Ohio
Department of Medicine/Rheumatology, Professor with Tenure
2008 - 2009 University of South Carolina, Columbia, S.C.
Department of Pathology, Microbiology & Immunology, School of Medicine, Professor with Tenure
2003 - 2008 Case Western Reserve University School of Medicine, Cleveland, Ohio
Department of Medicine, Division of Rheumatic Diseases, Professor of Medicine
1997 - 2003 Case Western Reserve University School of Medicine, Cleveland, Ohio
Department of Medicine, Division of Rheumatic Diseases, Associate Professor of Medicine
1990 - 1997 Case Western Reserve University School of Medicine, Cleveland, Ohio
Pathology & Dermatology, Department of Medicine, Division of Rheumatic Diseases, Assistant Professor of Medicine
1989 - 1990 Case Western Reserve University School of Medicine, Cleveland, Ohio
Division of Rheumatic Diseases, Department of Medicine, Senior Research Associate
1986 - 1989 Mayo Clinic, Rochester, Minn.
Department of Immunology, Senior Research Fellow (Mentor: Professor Chella S. David)
1984 -1986 Centre D'Immunologie de Marseille-Luminy, Marseille, France.
Fellow, Title of Project: Isolation, cloning and characterization of genes specifically expressed in cytotoxic T lymphocytes (Mentor: Professor Dr. Pierre Golstein)
1983 - Oct. 1984 Aligarh Muslim University, Aligarh, India.
Department of Science and Technology, Research Associate, Title of Project: Cloning the structural genes of restriction endonucleases EcoR1 and EcoRII (Mentor: Dr. S. M. Hadi)
1983 - Sept. 1983 Aligarh Muslim University, Aligarh, India
Department of Zoology, Lecturer
1981 - 1982 Aligarh Muslim University, Aligarh, India
Indian Council of Medical Research, Senior Research Fellow
1978 - 1979 Aligarh Muslim University, Aligarh, India
CSIR, Senior Research Fellow
Chondrocyte Biology, Gene Regulation, miRNAs, Signal Transduction, Alternative Medicine
More than 25 years of experience working in the field of inflammatory and degenerative joint diseases. Well versed in guiding post-doctoral fellows and research assistants in the use of molecular biology techniques including DNA, RNA preparation, cDNA synthesis and cDNA library construction, subtractive hybridization, isolation of genes, screening libraries, PCR, cloning and sequencing, Cytokine ELISAs, ELISA Spot Assay, Western blotting, DDRT-PCR, Real- time Quantitative PCR, Microarray Profiling, miRNA cloning and expression, etc.
More than two decades experience in the field of arthritis and inflammation, exploring the role of T cell receptor genes and T cell cytokines in the induction and pathogenesis of rheumatoid arthritis. Other funded projects are focused on determining the efficacy of specific plant products in vitro and in vivo. Additional studies are focused on determining the mechanism of gene regulation by miRNAs, modulation of signal transduction pathways by polyphenols and gene expression. Currently have my own small but focused group (2 Ph.D. Post Doctoral Fellows and 1 RA) supported by Two RO1 grants from NIH.
Haseeb A, Haqqi TM. Immunopathogenesis of osteoarthritis. 2013. Clin Immunol (in press)
Haseeb A, Cheng D, Haqqi TM. Delphinidin inhibits IL-1-induced activation of NF-B by modulating the phosphorylation of IRAK-1Ser376 in human articular chondrocytes. 2013. Rheumatology (in press)
Rasheed Z, Haqqi TM. Endoplasmic reticulum stress induces the expression of COX-2 through activation of eIF2α, p38-MAPK and NF-κB in advanced glycation end products stimulated human chondrocytes. 2012. Biochimica et Biophysica Acta. 1823:2179-89
Akhtar N., Haqqi TM. 2012. Current neutraceuticals in the management of osteoarthritis; a review. Ther Adv Musculoskel Dis. 4:181-207.
Akhtar N, Haqqi TM. MicroRNA-199a* regulates the expression of cyclooxygenase-2 (COX- 2) in human chondrocytes. 2012. Annals of Rheumatic Diseases. 711073-80.
Akhtar N and Haqqi TM. 2011. Epigallocatechin-3-gallate globally protects human chondrocytes from IL-1β-induced inflammatory response. Arthritis Res Ther Jun17;13(3):R93. [PMCID in process]
Singh R, Akhtar N, Haqqi TM. 2010. Green tea polyphenols epigalocatechin-3- gallate:Inflammation and arthritis. Life Sci. 2010 Jun 19;86(25-26):907-18. Erratum in: Life Sci. 2010 Jul 31;87(5-6):196.
Rasheed Z, Akhtar N, Khan A, Khan KA, Haqqi TM. 2010. Butrin, isobutrin, and butein from medicinal plant Butea monosperma selectively inhibit nuclear factor-kappaB in activated human mast cells: suppression of tumor necrosis factor-alpha, interleukin(IL)-6, and IL-8. J Pharmacol Exp Ther. 333(2):354-63. PMCID in process
Akhtar N, Rasheed Z, Anbazhagan AN, Voss FR, Haqqi TM. 2009. MicroRNA-27b Regulates the Expression of MMP-13 in Human Osteoarthritis Chondrocytes. Arthritis Rheum. 62:1361-1371.
Rasheed Z, Akhtar N, Anbazhagan AN, Ramamurthy S, Shukla M, Haqqi TM. 2009.Polyphenol-rich pomegranate fruit extract (POMx) suppresses PMACI-induced expression of pro-inflammatory cytokines by inhibiting the activation of MAP Kinases and NF-kappaB in human KU812 cells. J Inflammation (London) 6:1 tea polyphenol epigallocatechin-3-gallate inhibits advanced glycation end products- induced expression of tumor necrosis factor-alpha and matrix metalloproteinase-13 in human chondrocytes. Arthritis Res Ther. May15;11(3):R71. [Epub ahead of print]