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Alexander Galazyuk Ph.D.

Associate Professor of Neurobiology

Anatomy/Neurobiology

 

Phone: (330)325-6640

Location: 'E-124'

agalaz@neomed.edu

 

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Alexander V. Galazyuk, Ph.D.

Associate Professor of Anatomy and Neurobiology
College of Medicine

Faculty Laboratory Page

Education

1982                 Kiev State University, Kiev, Ukraine
                          M.Sc. in Human and Animal Physiology

1992                 A.A. Bogomoletz Institute of Physiology, Kiev, Ukraine.
                          Ph.D. in Physiology

Professional Experience

1973 - 1986     A.A. Bogomoletz Institute of Physiology, Kiev, Ukraine
                           Department of Physiology of Cerebral Cortex and Subcortical Structures; Senior
                           Technician

1986 - 1994     A.A. Bogomoletz Institute of Physiology, Kiev, Ukraine
                           Department of Physiology of Cerebral  Cortex and Subcortical Structures; Research 
                           Fellow

1994 - 1998     University of Illinois at Urbana-Champaign, Urbana, Ill.
                           Department of Molecular and Integrative Physiology; Postdoctoral Research Associate

1998 - 2003     University of Illinois at Urbana-Champaign, Urbana, Ill.
                           Department of Molecular and Integrative Physiology; Research Scientist

2003 -               Northeast Ohio Medical University, Rootstown, Ohio
                           2003 - 2010     Department of Neurobiology; Assistant Professor
                           2010 -               Department of Anatomy and Neurobiology; Associate Professor

2003 -               Kent State University School of Biomedical Sciences, Kent, Ohio
                           2003 -               Neuroscience Graduate Program; Graduate Faculty

Research Interests

Our research interests divide into three main areas:

  1. brain mechanisms responsible for development of phantom sensation of sound or tinnitus
  2. objective assessment of tinnitus in animal models and humans, and,
  3. neural mechanisms underlying complex sound processing.


(1, 2) Tinnitus, the perception of a sound without an external acoustic source, is a complex perceptual phenomenon affecting approximately 17 percent of the general U.S. population, or 44 million people. Despite its ubiquity and morbidity, the pathophysiology of tinnitus is poorly understood, and there is no generally accepted cure or treatment.

In our lab we developed tinnitus mouse model where tinnitus is induced by sound exposure and assessed behaviorally. This animal model allows us to study neural mechanisms responsible for tinnitus in the brain. We are also working on improving current methods of objective tinnitus assessment in animal models and humans. In collaboration with the Akron General Hospital we are studying suppressive effects of transcranial magnetic brain stimulation on tinnitus in humans.

(3)  Another focus of our research is on neuronal mechanisms underlying processing of complex sounds by neurons in the auditory system. We use a wide variety of neurophysiological approaches in our work including extracellular as well as intracellular recording from unanesthetized animals and iontophoretic drug delivery to recorded neurons.

Recent Publications

Dr. Galazyuk’s publications in PubMed

Longenecker RJ, Galazyuk AV. (2012) Methodological optimization of tinnitus assessment using prepulse inhibition of the acoustic startle reflex. Brain Res. [Epub ahead of print]

Voytenko SV, Galazyuk AV (2011) mGluRs modulate neuronal firing in the auditory midbrain. Neurosci Lett. 492: 145-149.

Longenecker R, Galazyuk AV (2011) Gap detection and prepulse inhibition in CBA/CaJ mice following noise exposure. J Assoc Res Otolaryngol. 12(5): 647-658

Voytenko SV, Galazyuk AV. (2010) Suppression of spontaneous firing in inferior colliculus neurons during sound processing. Neuroscience 165: 1490-1500.

Voytenko SV, Galazyuk AV. (2008) Timing of sound-evoked potentials and spike responses in the inferior colliculus of awake bats. Neuroscience. 155(3):923-936

Peterson, D.C., Voytenko, S., Gans, D., Galazyuk, A., and Wenstrup, J.J. (2008) Intracellular recordings from combination-sensitive neurons in the inferior colliculus J Neurophysiology 100(2):629-645.

Voytenko S, Galazyuk A. (2007) Intracellular recording reveals temporal integration in inferior colliculus neurons of awake bats. J Neurophysiol  97:1368-1378.

Wang X, Galazyuk AV, Feng AS.(2007) FM signals produce robust paradoxical latency shifts in the bat's inferior colliculus. J Comp Physiol A 193: 13-20.

Galazyuk, A.V., Lin W., Llano, D.A. and Feng, A.S. (2005) Leading inhibition to neural oscillation is important for time domain processing in the auditory midbrain. J Neurophysiol 94: 314-326.

Galazyuk, A.V. White, K.R., Feng, A.S. (2004) Temporal dynamics of amplitude-tuning in the inferior colliculus of the little brown bat. In: Echolocation in Bats and Dolphins, J. Thomas, C. Moss, and M. Vater, eds. University of Chicago Press, Chicago. pp 136-140.

Smalling J. M., Galazyuk, A.V., Feng, A.S (2001) Stimulation rate influences frequency tuning characteristics of inferior colliculus neurons in the little brown bat, Myotis lucifugus. NeuroReport 12: 3539-3542.

Galazyuk, A.V., Feng, A.S (2001) Oscillation may play a role in time domain central auditory processing. J. Neuroscience 21: RC147.

Galazyuk, A.V., Llano D., Feng, A.S (2000).Temporal dynamics of acoustic stimuli enhance amplitude tuning of inferior collicular neurons J. Neurophysiol. 83: 128-138.